Tag Archives: cell death
Extracellular cytochrome c: a novel damage-associated molecular pattern (DAMP) of the brain
Cytochrome c (CytC) is a protein that is normally located inside mitochondria where it participates in the energy-generating processes of cells. Since mitochondria are essential for life, these CytC-containing organelles are found in most animal cells. The
When cell death is better than cell survival: Monocyte response to lysates from different strains of Campylobacter jejuni
Campylobacter jejuni, a Gram-negative pathogen, is one of the leading bacterial causes of gastroenteritis world-wide. The invasion and multiplication of C. jejuni is a multistep process that includes interaction with the intestinal epithelial cells (IECs). The only
The synthetic cannabinoid XLR-11 and the impaired control of mitochondrial function by the endocannabinoid system as its underlying mechanism of nephrotoxicity
Synthetic cannabinoids (SCs) comprise a diverse group of new psychoactive substances (NPS) designed to activate at least one of the main cannabinoid receptors (i.e. CB1R, CB2R). Variations of SC have rapidly surfaced over the past few years,
Insulin effects on pancreatic beta cells-not always what you may think
Normally, blood glucose levels are controlled within a reasonable range by the release of insulin from pancreatic beta cells in response to an increase in blood glucose levels following a meal or other glucose challenge. One of
The oncolytic virus ∆PK has multi-modal anti-tumor activity
Oncolytic viruses (OVs) are an emerging cancer therapeutic based on tumor cell lysis by replicating virus and the resulting release of cellular proteins [viz. tumor-associated antigens (TAAs)], which modulate tumor immunogenic cell death (ICD). OVs have a
The variegated world of poly-ubiquitin chains
Proteins share with living beings the events of birth, life and death. They are ‘born’ when information contained in the DNA is translated into an amino acid chain and live their life in their natural environments (i.e.
Small or big, brain cells don’t like protein gunk that lead to diseases like Alzheimer’s, Parkinson’s and Huntington’s
An interdisiciplinary study by scientists at Trinity College Dublin (TCD, Ireland) have answered a hotly debated question in the neurodegenerative diseases research area: “Which protein aggregate form is the primary pathogenic agent in neurodegenerative diseases – (i) the prefibrillar oligomeric
