Tag Archives: cytokines
Serum cytokine profile in mice after injection of supernatants of group A streptococci culture
Cytokines are involved in various pathophysiological processes of macroorganism, including regulation of immune response and inflammation. Numerous experiments have demonstrated that cytokines, necessary in small doses, may result in the development of “cytokine storm” when produced in
Does intestinal inflammation impact the lung response to bacterial endotoxin?
Lung inflammation leading to airway hyperresponsiveness causes illnesses for more than ten percent of the population in USA. Recent research had indicated that patients with inflammatory bowel disease have higher incidence of airway hyperresponsiveness compared to the
Oxygen starvation promotes pro-tumorigenic cytokine expression
Identification of the factors that trigger tumor formation and metastasis is a problem that has persisted in cancer research since its inception. To date, studies have focused on chemical signaling compounds that are part of the secretome
Treatment critical limb ischemia with intramuscular administration of mesenchymal stem cells
Critical limb ischemia (CLI) is a severe form of peripheral artery disease, and associated with high rate of morbidity and mortality. The current standard for treatment CLI is revascularization. However, in any time surgical or endovascular revascularization
Immunological changes associated with hepatocellular carcinoma development
The body’s immune defense mechanisms play an important role in the inhibition or progression of liver diseases. We assessed the expression levels of different immune cells and cytokines in patients with chronic hepatitis C (CHC), liver cirrhosis
An introduction to modelling lymphocyte migration in vitro
Lymphocyte recruitment to inflamed endothelial cells (EC) is fundamental to immune homeostasis – providing both cell-mediated defence against disease, while also contributing to the resolution of inflammation. However, the dynamic relationship between lymphocytes and EC can become
Go with the flow: Studying the movement of T-cells to sites of inflammation
Inflammation is the protective response of the immune system that aids the removal of invading infectious agents and repair tissue injury. It involves the movement of white blood cells (leukocytes) from the bloodstream, through the cells lining
Conditioning the brain immune system through physical activity
Staying physically active is one of the most beneficial things that a person can do for maintaining whole-body health. It is well understood that physical activity is important for building muscle, improving cardiovascular health, and boosting metabolism.
The oncolytic virus ∆PK has multi-modal anti-tumor activity
Oncolytic viruses (OVs) are an emerging cancer therapeutic based on tumor cell lysis by replicating virus and the resulting release of cellular proteins [viz. tumor-associated antigens (TAAs)], which modulate tumor immunogenic cell death (ICD). OVs have a
Inflammation alters brain function and pain processing centrally
In the last couple of years, some fascinating abilities of the immune system have emerged: The immune system is tightly interconnected with the nervous system, and can directly affect how the brain functions, and how a person
Immunological disturbances observed in chronic alcoholism
Alcoholism is a complex behavioral disorder characterized by the loss of control over alcohol consumption often involving other drug abuse with a relapsing and remitting course leading to significant impairment. Chronic alcohol use and alcoholism damages many
Topical application of hyaluronidase accelerates cutaneous wound healing
Chronic wound care poses a significant biomedical burden. The management and treatment of chronic wounds affect millions of people annually; these numbers are rapidly growing worldwide owing to the increase in the aging population and a sharp
Electric fields drive macrophage healing functions
When the skin is cut, or otherwise injured, a spontaneous electrical current is created immediately at the wound and this promotes healing. Several studies have demonstrated how naturally generated electrical fields cause movement of skin epithelial cells,
Multiple injuries (polytrauma) result in skeletal muscle wasting and insulin resistance
Polytrauma is a combination of injuries that occur over a short period of time (simultaneously or within minutes of each other). These injuries can include burn, fracture, hemorrhage, trauma to the extremities, or penetrating trauma to the
Polyfunctional T cells induced potent anti-tumor efficacy
Adoptive T cell therapy is a form of cancer immunotherapy using T cells to target cancer cells. In adoptive T cell therapy, white blood cells are collected from cancer patients, T cells (CD4+ and CD8+ cells) within
Exorcising autoimmunity
Moderately intense physical exercise, performed at regular intervals, is now firmly recognized as a safe and effective intervention by which to enhance quality of life. Despite this awareness, for many of us, as our age increases, so
Endocrine regulation of Alzheimer’s disease. The Achilles heel of dementia and other neurological conditions
Alzheimer’s disease (AD) is the most common disorder of the central nervous system and the most frequent cause of devastating dementia in the elderly. Typified by loss of memory and by cognitive decline, AD lowers the quality
The cellular advantage of using a macrolide for community-acquired pneumonia
Community-acquired pneumonia has been one of the top ten causes of death in the US over the last 60 years despite the widespread use of antimicrobials. National guidelines (at idsociety.org) recommend two primary antibiotic regimens – one
The unappreciated role of the median eminence in energy balance regulation
Obesity results from a sustained imbalance between calorie intake and energy expenditure. It is associated with an increased risk of developing a variety of medical conditions that are widespread in Western countries, such as type 2 diabetes
The prognostic value of tumor markers and cytokines in patients with squamous cell cervical cancer
Optimal management of cervical cancer consists of appropriate treatment methods after the precise staging, following detection as early as possible, and the best salvage therapy. Early detection of recurrence, especially at the early stages in cervical cancer
