Tag Archives: diabetes
3D-printed chitosan scaffolds for the improved in-vivo wound healing in diabetic rats
In the tissue engineering context, fabrication of porous three dimensional (3D) printed chitosan (CH) scaffolds for skin tissue regeneration and their behavior in terms of biocompatibility, cytocompatibility and toxicity toward human fibroblast (Nhdf) and keratinocyte (HaCaT), was
Plasma CTSD activity: a non-invasive biomarker for hepatic insulin sensitivity
Due to the obesity epidemic, the incidence and prevalence of type 2 diabetes mellitus continues to rise globally. Type 2 diabetes is characterised by a relative insulin deficiency and an impaired insulin sensitivity in certain specific target organs. Insulin sensitivity can
Can “low calorie”-oil enhance the secretion of incretin hormones with beneficial effects on diabetic patients?
When the human body digests dietary fat (triacylglycerol), hormones from the intestine called incretins are released from the small intestine. These hormones stimulate insulin release and inhibit food intake. The mechanism for the fat-induced incretin release involves
Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment
Cardiac autonomic neuropathy (CAN) is a serious complication of diabetes mellitus (DM) that is strongly associated with approximately five-fold increased risk of cardiovascular mortality. CAN manifests in a spectrum of things, ranging from resting tachycardia and fixed
Risk of non-alcoholic fatty liver disease in patients with type-1 diabetes
In this modern world non-alcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease. It is defined as the presence of fatty liver disease in the absence of excess alcohol or
Not frozen in time: the past matters to the relationship between body weight and insulin
Insulin is a hormone which regulates how your food fuels your body. The food you eat is digested and converted into glucose, which then travels through your blood to reach all of the organs and tissues in
The role of oxidative stress in Type 2 diabetes
Type 2 diabetes is a major health concern that affects people no matter their gender, race, or socio-economic background is. In type 2 diabetes, a person’s body stops responding efficiently to insulin after a meal. This desensitization
Assessing the evidence on weight loss strategies
Weight loss and weight management is of upmost importance in our current climate of increasing rates of overweight and obesity and of associated diseases like type 2 diabetes. Here the evidence on weight loss strategies, in people
B-vitamins over-consumption may be the cause of the increased prevalence of obesity and diabetes
Obesity and type 2 diabetes have been a major health issue in the United States. It is during the past few decades that obesity and type 2 diabetes have rapidly reached epidemic levels not only in adults
Does statins increase risk of diabetes?
Statins are drugs that inhibit the enzyme 3-Hydroxy-3-methylglutaryl-coenzymeA (HMG-CoA) which is critical in the production of cholesterol molecules. Thus is commonly used in the treatment of abnormally elevated cholesterol which is known to contribute to cardiovascular disease
The most effective system to weight lost
People who suffer from morbid obesity are at high risk for many diseases, atherogenic dyslipidemia, elevated blood pressure, type 2 diabetes, thromboembolism, hepatic steatosis, proinflammatory state, etc. Metabolic syndrome is characterized by the clustering of some, or
Electrically controlled insulin release
Stimuli responsive materials are promising for designing the next generation of drug delivery systems. Such materials would enable drugs to be released on-demand or in response to patient needs, specifically at the target site, minimizing side effects.
Vistafin and endothelial progenitor cell dysfunction in diabetes mellitus
The prevalence of type 2 diabetes mellitus (T2DM) has been increased over recent decades, reaching worldwide epidemic. T2DM continues to exhibit a substantial impact on global health and requires increased expenditures of economic resources and medical care,
Type I interferons fuel adipose inflammation in obesity
When people get fat the visceral adipose tissue (VAT), fatty deposits inside the body that cling around the internal organs, get inflamed. This chronic low grade inflammation is termed metaflammation. Metaflammation has been found to contribute to
Gold-silver nanoparticles instead of traditional diabetic drugs
Recently, we have published a pioneering work on green biosynthesis and complete characterization of gold and core shell silver-gold nanoparticles (AuNPs and Ag@AuNPs) via using green biopolymer in the influence of microwave radiation. These synthesized nanoparticles provide
Diabetes and the heart – role of CT in predicting outcomes
People suffering from adult type diabetes mellitus have an increased tendency to develop disease of large and small arteries. Disease of the coronary arteries of the heart may lead to chest pain on exercise (angina pectoris) or
Reducing cellular stress may prevent diabetes complications
Poorly controlled diabetes is often associated with various complications including blindness, kidney failure and pain secondary to damaged nerves. However, the most common complications are those related to large blood vessel disease such as heart attacks and
Oligomers are building blocks of amyloid formation for insulin and its fast analog LisPro
The hormone insulin was discovered in 1921 by Banting and Best, and since that time it has been studied rigorously. At the same time first attempts were made to use insulin for treating diabetes. Insulin was the
