Tag Archives: diabetes
Chronic unpredictable environmental stress is harmful to humans
Stress refers to the mental and emotional change of state from normal homeostasis. In another words we can say that stress happens when we are worried for something and feeling uncomfortable. Chronic unpredictable environmental stress (CUES) refers
Novel genetics approach identifies GNAS gene as an important prerequisite for β-cell secretory capacity
Type 2 diabetes mellitus (T2D) is a major health burden in developing and industrialized countries (www.idf.org). Common genetic variations, susceptibility genes, epigenetic regulation, and miRNAs have been suggested to be profoundly involved in the pathogenicity of T2D.
Targeted GRP78 pathway for improved vision in diabetic retinopathy
Diabetic retinopathy, is a complication of diabetes which causes vision loss and eventual blindness in adults. People with diabetes have more sugar in their blood than normal, which causes their bodies not to function correctly. Often proteins
Why photobiomodulation therapy is helpful for diabetic wound healing? Fibroblast answers!
It is an obvious well-known issue that diabetic wounds are poorly healing, but the molecular and cellular alterations leading to this impairment is not clear. Many studies concluded the dysfunction of dermal fibroblasts as the main responsible
The roles of mesenchymal stem cells secretome in diabetic wound healing
There has been a fourfold rise in the number of diabetics from 108 million in 1980 to 422 million in 2014 and by 2040 the number will reach to 642 million. Diabetes mellitus drastically influences normal functioning
3D-bioengineered human amniotic membrane scaffold for improvement of wound healing in diabetic rats
In the tissue engineering context, attention to the biological scaffolds due to the safety, efficacy, and bio-mimicity was discussed. Among the natural scaffolds, human amniotic membrane (HAM) has shown to be promising and has been used for
Metformin improves pancreatic cancer and lymphoma outcomes in DM2 patients
Type 2 diabetics are at increased risk of cancer in part because of increased insulin in the blood from insulin resistance. Insulin and its related growth factor IGF-1 can stimulate cell growth through the Ras-Raf-MEK-ERK or the
Kelp extracts and their pharmaceutical properties
Kelps are a specific type of large brown seaweeds that generally grow on rocky, shallow, nutrient-rich ocean water. The most common examples of kelps found in the South African coastlines include Ecklonia maxima (sea bamboo) (Fig. 1), Ecklonia
Early detection of “insulin balls” using ultrasonography
Diabetes patients often suffer from subcutaneous induration at insulin injection sites during insulin therapy. Among the different types of subcutaneous complications of insulin injection, lipohypertrophy and insulin-derived amyloidosis (IDA) are defined as tumor-like enlargements of adipose tissue
3D-printed chitosan scaffolds for the improved in-vivo wound healing in diabetic rats
In the tissue engineering context, fabrication of porous three dimensional (3D) printed chitosan (CH) scaffolds for skin tissue regeneration and their behavior in terms of biocompatibility, cytocompatibility and toxicity toward human fibroblast (Nhdf) and keratinocyte (HaCaT), was
Plasma CTSD activity: a non-invasive biomarker for hepatic insulin sensitivity
Due to the obesity epidemic, the incidence and prevalence of type 2 diabetes mellitus continues to rise globally. Type 2 diabetes is characterised by a relative insulin deficiency and an impaired insulin sensitivity in certain specific target organs. Insulin sensitivity can
Can “low calorie”-oil enhance the secretion of incretin hormones with beneficial effects on diabetic patients?
When the human body digests dietary fat (triacylglycerol), hormones from the intestine called incretins are released from the small intestine. These hormones stimulate insulin release and inhibit food intake. The mechanism for the fat-induced incretin release involves
Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment
Cardiac autonomic neuropathy (CAN) is a serious complication of diabetes mellitus (DM) that is strongly associated with approximately five-fold increased risk of cardiovascular mortality. CAN manifests in a spectrum of things, ranging from resting tachycardia and fixed
Risk of non-alcoholic fatty liver disease in patients with type-1 diabetes
In this modern world non-alcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease. It is defined as the presence of fatty liver disease in the absence of excess alcohol or
Not frozen in time: the past matters to the relationship between body weight and insulin
Insulin is a hormone which regulates how your food fuels your body. The food you eat is digested and converted into glucose, which then travels through your blood to reach all of the organs and tissues in
The role of oxidative stress in Type 2 diabetes
Type 2 diabetes is a major health concern that affects people no matter their gender, race, or socio-economic background is. In type 2 diabetes, a person’s body stops responding efficiently to insulin after a meal. This desensitization
Assessing the evidence on weight loss strategies
Weight loss and weight management is of upmost importance in our current climate of increasing rates of overweight and obesity and of associated diseases like type 2 diabetes. Here the evidence on weight loss strategies, in people
B-vitamins over-consumption may be the cause of the increased prevalence of obesity and diabetes
Obesity and type 2 diabetes have been a major health issue in the United States. It is during the past few decades that obesity and type 2 diabetes have rapidly reached epidemic levels not only in adults
Does statins increase risk of diabetes?
Statins are drugs that inhibit the enzyme 3-Hydroxy-3-methylglutaryl-coenzymeA (HMG-CoA) which is critical in the production of cholesterol molecules. Thus is commonly used in the treatment of abnormally elevated cholesterol which is known to contribute to cardiovascular disease
