Tag Archives: diabetes

Reducing cellular stress may prevent diabetes complications

Poorly controlled diabetes is often associated with various complications including blindness, kidney failure and pain secondary to damaged nerves. However, the most common complications are those related to large blood vessel disease such as heart attacks and

Oligomers are building blocks of amyloid formation for insulin and its fast analog LisPro

The hormone insulin was discovered in 1921 by Banting and Best, and since that time it has been studied rigorously. At the same time first attempts were made to use insulin for treating diabetes. Insulin was the

Small fish can help finding drugs to fight retina diseases

About 285 million people are visually impaired in the world. The arising of chronic eye diseases and ageing processes make more people at risk of blindness, 65% of visually impaired people being aged 50 or older. Among

Prevention of type 2 diabetes: Prevention of beta cell “karoshi”

The number of patients with type 2 diabetes (T2DM) continues to increase despite the recent advances in pharmacological therapies for T2DM. This fact indicates that we still may not sufficiently understand the pathophysiology of this disease. By

Early treatment with basal insulin glargine in people with type 2 diabetes: Lessons from ORIGIN and other cardiovascular trials

The inability to control blood glucose levels can result in many negative health outcomes including eye, kidney, cardiovascular (heart) and foot disease, and early death.  Persons with type 2 diabetes are 2 to 4 times more likely

Oxytocin and human Central Diabetes Insipidus in relation to the different hydromineral animal models

Central Diabetes Insipidus (CDI) is a disorder caused by a deficit in the production of arginine vasopressin (AVP), a hormone that acts by binding to AVP receptor 2 (AVPR2) on the kidney collecting tubule cells and produces

Prevalence of hospitalisation resulting from medicine related problems among adult patients with cardiovascular diseases and/or diabetes

Cardiovascular diseases ( CVDs ) and diabetes ( DM ) are two interrelated groups of diseases that contribute to more than 50 % of death worldwide. Patients with CVDs and / or DM often take multiple medicines

Long-term outcome in patients admitted with a heart attack and detected with increased blood sugar levels during admission

An Oral Glucose Tolerance Test ( OGTT ) is one of the diagnostic tests to determine the presence of pre – diabetes or manifest diabetes. An OGTT involves drinking a 75 gram sugar solution after 8 hours

Can you reduce your risk of diabetes with lifestyle changes?

Glucose homeostasis deficiency may lead to chronic increase in blood glucose levels and could affect a large number of tissues and organs.  The shift from early metabolic abnormalities that forego diabetes, such as impaired fasting glucose and

Optimizing diabetes care on a global scale

Diabetes is a major threat to healthy living for hundreds of millions of people worldwide.  Type-1 diabetes must be treated with insulin and type-2 diabetes (the more common form) can be treated with lifestyle changes, oral medication,

AMPK: How can we amp it up to fight disease?

The high prevalence of obesity, insulin resistance, type 2 diabetes and cardiovascular disease has made it clear that we need a better understanding of how our bodies store and use energy when we overload them with excess

Active role of cell-derived microparticles in diabetes associated cardiovascular complications

Diabetes mellitus is a metabolic disorder characterized by high blood glucose (or hyperglycaemia) resulting from defects in insulin secretion from the pancreatic beta cells, insulin action, or both. The chronic hyperglycaemia produces disturbances of carbohydrate, fat and

Insulin analogue with reduced weight gain effect in diabetic patients: detemir

Diabetes mellitus is a progressive condition in which the glycated hemoglobin level (i.e. marker of average blood glucose levels) rises inexorably over time. Strict glucose control in patients with type 1 or type 2 diabetes mellitus reduces

Statins and diabetes: do the benefits outweigh the risks?

Cardiovascular disease (heart attack and stroke) is the leading cause of death in the United States. Prescription cholesterol-lowering medications have been shown to lower the risks for heart attacks and stroke. In fact, roughly 28% of Americans

Can antioxidants benefit the diabetic kidney?

People who have diabetes are at high risk of developing kidney disease that may require dialysis or transplantation. This has been known for a long time but there is still a need for new ways to prevent

New advances in the classification of diabetes beyond type 1 and 2: monogenic diabetes

The classification of diabetes has become increasingly complex in recent years, particularly in young patients, and now goes beyond the traditional forms of type 1 and type 2 diabetes. Type 1 diabetes, which is linked to the

A better way to measure heart disease risk for an overweight society

Low density lipoprotein (LDL) cholesterol or the “bad cholesterol” is an established measure of cardiovascular risk. LDL particles interact with the lining of the blood vessel and contribute to cholesterol loading in the arterial wall. Continued buildup

The earlier, the better and the controlled. Glucose level sensing in diabetic patients through nano biosensors

Gone are the days when there was a big pain for patients suffering from high blood glucose (blood sugar) level that early and rapid detection was a long wait & rather unpleasant. Now recently developed approaches using

A new drug target for healthful aging

With the aging population of the United States increasing every year, there is an increasing need to develop new therapeutic modalities to provide for healthful aging. Although longevity is generally considered positively in most families, and of

Poor blood sugar control in elderly people with diabetes is associated with increased infection risk

Diabetes guidelines for doctors (such as those by NICE) suggest that they consider relaxing the blood sugar control targets for older people. This is because older people are less likely to get the long-term benefits of improved