Tag Archives: diagnosis
Can we accurately diagnose different clinical variants of Progressive Supranuclear Palsy using IPMDS-PSP criteria?
Progressive Supranuclear Palsy (PSP) is the second most common degenerative parkinsonian syndrome after idiopathic Parkinson’s disease. PSP is a clinically heterogeneous disorder with several clinical variants. The two most common clinical variants are the Richardson (PSP-RS) and
The use of olfactory neuronal precursors for antemortem Alzheimer’s Disease diagnosis
Alzheimer’s disease (AD) is a disabling and progressive illness that causes a high social cost and economic burden. Current diagnosis has been done by clinical appreciation based on the Diagnostic and Statistical Manual of Mental Disorders (DSM–5) and
Adverse food reactions in cats: 1000 cases
Wholesome nutrition is the key to maintaining a healthy immune system and resistance to disease. Commercial foods given to animals may not be truly balanced in major nutrients, minerals and vitamins, and some have chemicals added to
Specific and non-specific biomarkers in neuroendocrine gastroenteropancreatic tumors
Neuroendocrine tumors (NETs) are a heterogeneous group of rare malignancies that can arise in almost all organs, although gastroenteropancreatic site (GEP) is the most common. Symptoms are rarely specific, and clinical manifestations may be evident only in
Insight into the needs of thyroid cancer patients before surgery
The thyroid is a butterfly-shaped gland in the neck below the Adam’s apple. It produces hormones that help influence our metabolism and normal development. Over the last 30 years, the number of new thyroid cancer diagnoses has
Trends in heart failure diagnosis for women and men in urban and rural settings in Ontario
Heart failure remains a significant cause of death and disability for women and men. It is estimated that 1 in 5 individuals will be diagnosed with heart failure in their lifetime, with an average survival of approximately
Ovarian torsion or something else
Ovarian torsion, also termed as adnexal torsion, is the total or partial twisting of the ovary and almost always involves part of the fallopian tube. The incidence of adnexal tumors increases with age and one of the
Crossing borders to accelerate diagnosis of neurodegenerative diseases
Neurodegenerative diseases of the Central Nervous System are affecting 50 million people worldwide. The forecast is that these numbers will steeply increase due to the aging population. These diseases are difficult to diagnose, due to a substantial
Clostridioides difficile infections: what is new in laboratory diagnosis and clinical treatment
Clostridioides difficile infections (CDI) have become a major economic issue from developing countries as well as from the Western World. Early and accurate diagnosis of CDI allows earlier treatment, which can significantly reduce the morbidity, mortality, medical
Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment
Cardiac autonomic neuropathy (CAN) is a serious complication of diabetes mellitus (DM) that is strongly associated with approximately five-fold increased risk of cardiovascular mortality. CAN manifests in a spectrum of things, ranging from resting tachycardia and fixed
A novel quantitative iron imaging strategy in hereditary hemochromatosis based on LA-ICP-MS
Hereditary hemochromatosis (HH) is the most frequent genetic disorder in Caucasians, which affects about 1 in 1000 people in the Northern European ancestry. It is an iron overload disease with typical clinical symptoms resulting from excess body
The looming peril of neglected indigenous arbovirus infections to population expansion in Northern Australia
Viruses that are transmitted between vertebrate hosts by biting, blood-feeding arthropods (principally mosquitoes and ticks but also sandflies and midges) are called arthropod-borne viruses or, for short, arboviruses. The transmission of arboviruses to humans poses a significant and
Is schizophrenia disappearing?
Psychosis is a mental state with grossly impaired reality testing, manifesting as different mixtures of delusions, hallucinations, deviant thinking and abnormal motor behaviour – so-called positive symptoms. Negative symptoms – reduced emotions, interests, will and social participation
Cystic lesions of the pancreas – are we good enough at predicting the right diagnosis in order to make a suitable treatment choice?
The incidence of pancreatic cystic lesions (PCL) is steadily increasing, most likely due to the common use of cross-sectional abdominal imaging and its technical improvements during the past decade. The majority of these lesions are benign at
Could low albumin be a marker of an undiagnosed cancer?
Cancer is an increasingly common problem that affects one-in-two British people over the course of their lifetime. Survival rates are getting better with increased awareness, better tests and more effective treatments, but the UK still lags behind
Family, cholesterol and the genes from the ground up or why screening matters
In 1913, the “cholesterol theory” of atherogenesis was proposed. In the 1930s a genetic disorder, familial hypercholesterolemia (FH), which is associated with elevated levels of low-density lipoprotein (LDL) cholesterol and high risk of heart attack at an
How realistic is the potential global spread of Zika virus and should we all be worried?
Unless you have taken a holiday on Mars for the whole of this year no doubt by now you will have heard of Zika. This is the virus that has emerged in the last 18 months to
Seeing the signs: Acromegaly
Acromegaly is a rare disorder typically caused by a growth hormone (GH)-producing tumor in a small gland at the base of the brain: the pituitary. This organ is a “master gland”, controlling the production and release of
Cushing’s Disease – why is the diagnosis so difficult?
Cushing’s disease, named after the neurosurgeon Harvey Cushing, and caused by an adrenocorticotroph hormone (ACTH)-secreting benign tumor of the pituitary, is a rare illness. The pituitary is a gland at the base of the brain that secretes
Diagnosis of concussion in children
Children frequently injure their heads during play and sport, which often leads to visits to the Emergency Department (ED) to be checked by a doctor. Concussion is a type of brain injury, which requires an accurate and
