Tag Archives: disease

Intracranial injections and animal models: towards understanding and treating human disease

AoS. Intracranial injections and animal models: towards understanding and treating human disease

The use of laboratory animals helped us to better understand a myriad of biological processes in health and disease and enabled the development of therapies that effectively cure, or ameliorate life conditions of, millions of people every

Macrophage-myofibroblast transition: a novel target for stopping kidney disease

AoS.Macrophage-myofibroblast transition

Kidney is one of the major organs in our body for detoxification. Its failure is an important cause of patient mortality that serves as a primary disease and a lethal complication in a range of diseases such

Prevention of congenital heart anomalies: the secret kept by embryonic stem cells

AoS. Prevention of congenital heart anomalies

CITED2 is a transcriptional modulator involved in the regulation of the expression of many other genes in vertebrates. At very early stages of embryo development, CITED2 is particularly important for heart formation, a process also termed cardiogenesis.

Exploring the potential of a pneumococcal vaccine to target oxidized LDL in metabolic disease patients

AoS.Exploring the potential of a pneumococcal vaccine to target oxidized LDL in metabolic disease patients

Lipid metabolism involves a wide range of processes in which lipids are processed and used as energy sources, signaling molecules and structural elements of cells. Given its importance, dysfunctions in lipid metabolism, both small and large, can

Upstream open reading frames (uORFs) as translational regulators in human disease

AoS. Upstream open reading frames (uORFs) as translational regulators in human disease

The messenger RNA (mRNA) translation process is a key step of gene expression, whose regulation allows the cell to rapidly change protein synthesis in a spatio-temporal manner in response to different stimuli. Translation comprises four steps –

Nonsense-mediated mRNA decay (NMD): a bifunctional mechanism in human physiology and disease

AoS. Nonsense-mediated mRNA decay (NMD)

Proteins are the working-units of the cell, which are encoded by thousands of genes that pass their information into an intermediate molecule, the messenger RNA (mRNA). For this flow of information – from genes to RNA (transcription),

More than your average bread spread: plant stanols as therapeutical tool in Niemann-Pick type C1 disease

Niemann-Pick type C1 (NPC1) disease is a lysosomal storage disease that affects nearly 1 in 100,000 live births worldwide. NPC1 disease is caused by mutations in the NPC1 gene that result in a dysfunctional NPC1 protein, which

A new strategy for immune manipulation of advanced solid cancers

A new strategy for immune manipulation of advanced solid cancers. AoS

The biological cancer hallmarks and the current model In the updated ongoing model, genomic instability and inflammation are the basis of all the cancer hallmarks: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality,

Mitophagy in health and disease

Mitophagy in health and disease. AoS

Mitochondria are cellular organelles specialized for energy production, and critically influence several features of cellular metabolism and physiology. Maintenance of a healthy mitochondrial pool is a prerequisite for cellular and tissue homeostasis. Compromised mitochondrial function results in

Stem cells and stem cells conditioned medium for inflammatory bowel disease treatment

Stem cells. AoS

Inflammatory bowel disease (IBD) is a complex of pathological processes occurring in the intestine. Chemically induced IBD in rodent usually used for study of drug therapy efficacy. Mesenchymal stem cells (MSC) was used as alternative method for

Be careful of podocyte B7-1

Chronic kidney disease . Atlas of Science

Chronic kidney disease (CKD) is a huge global health burden. If not treated promptly, CKD can progress to end-stage renal disease, meaning that kidney function is at below 10% of normal capacity. Under physiological conditions the kidneys

Biomarkers for Alzheimer’s disease diagnosis: an eye on retinal inflammation

Biomarkers for Alzheimer’s disease diagnosis. AoS

Alzheimer’s disease is one of the most common neurodegenerative disorders. Alzheimer’s disease cases are constantly increasing worldwide due to population aging. Typical symptoms of the disease include memory loss, cognitive deficits, personality and behavior modifications. At the

Celiac disease and liver disorders

Gut-liver axis and putative pathogenesis of liver injury in celiac disease. AoS

Immunologically mediated liver diseases belong to the common extraintestinal manifestations of celiac disease. In celiac disease, increased intestinal permeability is thought to be an early feature in the pathogenesis. Dietary gluten drives intestinal inflammation and impairs the

Vitamin D deficiency is a sign of poor health in chronic obstructive pulmonary disease

Vitamin D deficiency is a sign of poor health in COPD

Vitamin D is an important hormone in growth and bone metabolism. Vitamin D deficiency is highly prevalent worldwide and causes growth retardation and rickets in children and osteomalacia in adults. However, the role of vitamin D deficiency

Repetitive DNA in the ABCA7 gene influences Alzheimer’s disease

Repetitive DNA in the ABCA7 gene influences Alzheimer’s disease

Dementia, which is characterized by decline of memory or other cognitive traits to the extent that a person’s daily functioning is affected, is one of the most important global health challenges of our time. Approximately 50 million

Crossing borders to accelerate diagnosis of neurodegenerative diseases

Steps in biomarker development process

Neurodegenerative diseases of the Central Nervous System are affecting 50 million people worldwide. The forecast is that these numbers will steeply increase due to the aging population. These diseases are difficult to diagnose, due to a substantial

Parkinson disease: a tale of three neurotransmitters

The progressive loss of dopaminergic innervation of the basal ganglia, in particular of the dorsal striatum (putamen) is responsible for the motor signs of Parkinson disease such as bradykinesia, rigidity and loss of postural reflexes. Present therapies

Uncertain pathogenicity of mutations in Wilson gene

Uncertain Pathogenicity of Mutations in Wilson Gene

Wilson’s disease is caused by an autosomal recessive disorder of the hepatic copper transport of ATP 7B. The responsible gene is located on the long arm of chromosome 13. Currently more than 500 mutations are known which

Chronic pancreatitis: an inflammatory disease of pancreas

Chronic Pancreatitis: An Inflammatory Disease of Pancreas

Pancreas is very important organ in our body and it is located in the abdomen behind the stomach. Pancreas is a gland and secrets some chemicals called enzymes. It is a leaf like structure and divided in