Tag Archives: disease

Statins: Good for the heart, but do they impact the brain?

High cholesterol, termed hyperlipidemia, is a risk factor for cardiovascular disease. Therefore, keeping cholesterol levels low through diet and exercise has proven benefits for reducing heart disease risk. For adults who cannot meet their cholesterol targets through

Compounded medication for patients with rare diseases

Pharmaceutical compounding is the preparation of unlicensed medicines in order to meet specific patient needs that do not have a licensed (commercial) medicine available on the market. Especially for patients with rare diseases it is complementary when

Training the immune system to treat Niemann-Pick type C1 disease

Every year, at least 1 in 100,000 people worldwide is born with Niemann-Pick type C1 (NPC1) disease, a lysosomal storage disease. Lysosomes are cellular compartments which process an array of substrates – from DNA to nutrients –

Midkine controls natural bypass growth by regulating the bioavailability of VEGF

Cardiovascular occlusive diseases such as stroke, myocardial infarction or perivascular artery diseases (PAD) are a major personal and social burden. According to the World Health Organization, vascular occlusive diseases are the leading cause of death worldwide.  Current

A novel quantitative iron imaging strategy in hereditary hemochromatosis based on LA-ICP-MS

Hereditary hemochromatosis (HH) is the most frequent genetic disorder in Caucasians, which affects about 1 in 1000 people in the Northern European ancestry. It is an iron overload disease with typical clinical symptoms resulting from excess body

Can we treat cancer by targeting Treg subset without causing autoimmune disease?

The regulatory T cells (Tregs), are a type of CD4+ T cells that suppress the potentially adverse effect of the immune system and prevent autoimmune disease. Although they play a central role in maintaining self-tolerance, Tregs also

Angiotensin II actions on distal regulatory elements promote vascular dysfunction and hypertension

Cardiovascular diseases such as hypertension (high blood pressure) and atherosclerosis (blocked blood vessels) lead to heart attacks and strokes, and are highly prevalent worldwide. Furthermore, these complications are significantly accelerated in patients with diabetes. Angiotensin II (AngII)

A new drug to improve drug-eluting stents in coronary artery disease

Patients with symptomatic coronary artery disease often receive stent treatment in obstructed coronary arteries of the heart. Even though current generation drug-eluting stents perform very well in the short-term, concerns still exist about their long-term efficacy due

Prevalence of anti-DFS70 antibodies in patients with and without systemic autoimmune rheumatic diseases

The main role of the immune system is to protect the body from a wide range of foreign invaders. In some cases, the immune system recognizes a part of the body as “foreign” and starts to attack

Keyhole heart valve surgery after previous heart transplantation

Advances in heart transplant techniques and medication that control rejection and infections resulted in improved survival and quality of life. These improved long term outcomes are unfortunately paralleled by a variety of associated coronary-, mitral- and tricuspid

Could the humble banana help mitigate diseases?

Musa acuminata, is the scientific name of the wild species of banana that has reinvigorated interest in finding cures for diseases such as cancer, HIV and many more. The wild banana habituates the tropical and subtropical regions

Breathing problems in Parkinson’s disease: a common problem, rarely diagnosed

Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease. It is characterized by bradykinesia (slowness in movement) tremor, rigidity, and postural instability. Potential non-motor manifestations of PD include depression, anxiety, constipation, overactive bladder

TAFRO-syndrome and idiopathic multicentric Castleman disease: An analysis of a new subtype of the rare disease

Castleman disease (CD) is a group of three rare, poorly understood diseases that all involve excessive lymphocyte quantities. All three groups, therefore, are categorized as lymphoproliferative disease. The three groups of Castleman disease share similar lymph node

Overcome obstacles in the treatment of scarred kidneys

More than 10% of the world’s population suffer from chronic kidney disease (CKD), a serious disorder that leads to a prominent reduction in quality of life and might end fatally. Independent of its initial cause, virtually all

Urea is truly toxic: the empire strikes back

Urea is a metabolic waste product that accumulates in the body in the setting of chronic kidney disease. It is routinely measured on blood tests as a marker of kidney function (higher urea levels indicate lower kidney

Electrically controlled insulin release

Stimuli responsive materials are promising for designing the next generation of drug delivery systems. Such materials would enable drugs to be released on-demand or in response to patient needs, specifically at the target site, minimizing side effects.

The journey of Campylobacter: a genomic analysis of a successful zoonotic pathogen

Campylobacter is the leading cause of human gastroenteritis worldwide. Domestic and wild birds are likely zoonotic vectors of Campylobacter. We demonstrated that American crows, abundant in urban, suburban, and agricultural settings, carry multiple Campylobacter genotypes that are

Conformal invariants for landmark curve based brain morphometry analysis

Abnormal structural changes measured on cortical surfaces are important biomarkers for Alzheimer’s disease (AD). In brain imaging research, landmark curves are usually delineated on cortical surfaces to represent significant sulcus and gyrus patterns. Landmark curves are widely

Production and diseases of dairy cows: genetics (cause) and management (effect)

The milk production of dairy cows has been increased during the last decades by animal-husbandry, improved feeding regime, extensive veterinary service and proper management. It can be assumed that this tendency will be continued in the future

Brucellosis, tuberculosis and caprine arthritis-encephalitis, are goats and sheep in El Salvador affected?

Brucellosis and tuberculosis are two animal diseases that occur in Salvadoran cattle and humans may get infected by drinking raw milk. When herds get infected for the first time with brucellosis, massive abortions in the last third