Tag Archives: DNA repair

A DNA repair gene, OGG1, polymorphism affects relapse risk of acute myeloid leukemia

A DNA repair gene, OGG1, polymorphism affects relapse risk of acute myeloid leukemia

Approximately 80% of acute myeloid leukemia (AML) patients can achieve complete remission, but around half of them relapse within five years. Defining the mechanism of relapse is essential to improve the prognosis of AML. Recently, a clonal

Let-7b expression in breast cancer: does have any implications on the DNA repair capacity?

Epigenetics study the changes on gene expression that occur without altering the primary structure of the DNA. Examples of epigenetic mechanisms that can produce such changes include microRNA ( miRNA ) silencing, DNA methylation, histone methylation, among

Why is radiation treatment more effective for cancers caused by HPV?

Human papilloma virus (HPV) is the most common sexually transmitted infection in the United States and can lead to cancers in the affected organ such as the cervix. In the last 15 years, the rise in prevalence

Changes in 3-dimentional chromatin structure as a mean to relieve oxidative stress?

DNA in our cells is packaged into a structure called chromatin, which is mainly a protein-DNA complex. Chromatin needs to be loosened for fundamental processes to take place, such as decoding genetic information (i.e. gene expression) and

What does a guardian protect genomic DNA from?

Living organisms can achieve their propagation through copying (replicating) the genetic information, coded in DNA sequence, and dividing them to each daughter cell. DNA sequence is a basic element and its conservation is essential for individual life

NEIL2 repairs DNA damage within active genes, maintains chromosome end integrity, prevents inflammation

Mammalian cells are subjected to a plethora of exogenous and endogenous agents that cause damage to the cellular DNA. One of the major sources of such damage is oxygen-derived molecules and free radicals, collectively termed “Reactive Oxygen

Geology’s latest gift to molecular biology?

Only a few hardy bacteria and archaea make their home in geothermal springs, but the enzymes of these thermophiles have for decades benefitted biological research.  While the value of the bacterial DNA polymerase “Taq” in amplifying DNA

The TMPRSS2-ERG fusion gene radiosensitizes to PARP inhibition by blocking DNA repair

Radiotherapy, which is used widely in the clinic, produces DNA damage that leads to DNA double-strand breaks (DSBs). The effectiveness of radiotherapy is augmented when the DNA repair is impaired. TMPRSS2-ERG is a unique fusion gene that

Repair of damaged genetic material in humans

Living organisms across the evolutionary scale protect their genetic material (DNA) by repairing the constant threat of damage posed by environmental radiations, toxic chemicals, and byproducts of cellular metabolism. In the early 60s, Setlow and Howard-Flanders at