Tag Archives: drug development
Why Outsourcing is Key to the Future of Drug Development
COVID-19 showed us the importance of improving the speed to market of new drugs such as vaccines. And with more challenges facing the industry than ever before, fast and reliable drug development has never been more vital.
Cryo-electron microscopy in drug development
Cryo-electron microscopy (cryo-EM) is becoming the method of choice in structure determination of membrane proteins and has great potential for structure-based drug discovery (SBDD). Cryo-EM provides high-resolution structural information of a membrane protein without the need for
Rethinking drugs’ development in acute heart failure?
Acute heart failure (AHF) affects 1-2% of adults in developed countries. It strikes mainly people above the age 60, peeking in those older than 85 (prevalence ~ 17.4%). AHF is a life threatening medical event, with gradual
A new strategy to drug development for neuromuscular disorder
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a neurodegenerative disease in which motor neuron (MN) loss in both the spinal cord and motor cortex causes progressive paralysis, muscle atrophy, and death. So far,
Acute ischemic stroke: An urgent call for help and funding!
In humans, acute ischemic stroke is the primarily result of a blood-clot that moves toward the brain and blocks one or more important blood vessels that supply blood, oxygen, and nutrients to brain tissue (Fig. 1), causing
Throwing a wrench into the hepatitis C replication machine
As an essential step in its replication cycle, the human hepatitis C virus (HCV) must make a copy of its RNA genome. The major player in this process is the NS5B polymerase, a molecular machine which uses