Tag Archives: drug resistance
Eavesdropping on cell communications to treat cancer with drug resistance
An estimated 19.3 million new cancer cases and almost 10 million cancer deaths occurred worldwide in 2020. It’s estimated that one in three individuals will be diagnosed with some kind of cancer in their lifetime. When cancer
Perspectives for anti-tuberculosis therapy with additional drug activities to counteract drug resistance
Generally, antibiotic therapies use single antibiotics to combat sensitive bacteria. The standard of antituberculosis therapy includes four antibacterial agents that all have different modes of activities in the initial phase of a tuberculosis infection with mycobacterium tuberculosis.
Cost-effectiveness of rapid diagnosis of drug-resistant tuberculosis
Globally, tuberculosis (TB) is a leading cause of premature death. There are treatments for tuberculosis, but drug-resistant strains of tuberculosis have emerged, mostly due to improper or incomplete treatment. If diagnosed properly in a timely manner, extremely
Lernaean hydra puzzle in compensatory angiogenesis and tumor drug resistance
Before we proceed to apply the analogy of Lernaean hydra to compensatory angiogenesis and tumor drug resistance against anti-angiogenic drugs (AADs), let us have a cursory look at the interesting mythology of this hydra. According to Greek
A drug resistance gene mediates stringent response in bacteria
Mycobacteria represent an important group of bacteria. Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects about a third of the world population, of which 5% to 15% develop active disease. Furthermore, a rapid emergence of multidrug
Negative regulators of cell death signalling pathways in cancer
Cancer is a primary cause of human death with a global economic toll of around US$1.4 trillion each year. It is estimated that about 12 million people will yearly die of cancer by 2030. Conventional cancer therapies such
How does phenobarbital, a therapeutic sedative, activate a nuclear receptor through phosphorylation?
Steroid hormones activate a family of nuclear proteins called nuclear receptors to regulate every aspect of human physiology, reproduction, development, differentiation, metabolism and immunity. A nuclear receptor molecule is comprised of two major structural domains; DNA-binding (DBD)
A novel and quick method to study the drug resistance in reverse transcriptase (RT) of HIV
Human immunodeficiency virus (HIV), a retrovirus, was discovered independently by Luc Montagnier and Robert Gallo in 1983. As per the WHO report of 2015, globally, around 40 million people are infected with this virus. HIV is an
Holding the last line of defence against malaria
Malaria contributed to the deaths of almost half a million people worldwide in 2015. This disease mainly affects people in the developing countries and imposes a serious health and financial burden. Artemisinin (ART)-based combination therapy is the
Metabolic reprogramming: from estrogen dependence to self-sufficiency
Breast cancer is the most common cancer in women and, despite significant progress in diagnosis and treatments, incidence has been steadily increasing in the last 40 years. Approximately 70% of breast cancers are characterised by the expression
Is isoniazid so safe to use in tuberculosis preventive therapy?
Tuberculosis (TB) has emerged as a major warning to global public health as thirty three percent of the world population is considered to be infected with Mycobacterium tuberculosis (MTB) infection. Further, multi-drug-resistant strains of MTB in association
Truncated INH-NAD adduct, an active intermediate in the action of Isoniazid (INH) against InhA enzyme in tuberculosis
Tuberculosis (TB) remains as an important infectious disease, caused by Mycobacterium tuberculosis (MTB) which is responsible for around 1.5 million deaths and 9.6 million new cases annually. Isoniazid (INH), a bactericidal compound used as a first-line drug
Polyamine transport increases drug resistance in the parasite Trypanosoma cruzi
The parasite Trypanosoma cruzi is the causative agent of Chagas disease, an illness affecting millions of people in America. The only drugs approved against Chagas disease are nifurtimox and benznidazole, which were discovered almost half a century
Mitochondrial ROS and cancer drug resistance
The repetitive and continuous circle of resistance to anti-cancer agents was a primary focus of the above-titled articles recently published in Pharmacological Research. Gaining a basic understanding of why so many (possibly all) drugs currently available against
