Tag Archives: drug

How AI Is Revolutionizing Drug Discovery

AoS. How AI Is Revolutionizing Drug Discovery

Artificial intelligence (AI) is making significant strides in drug discovery, transforming how new medications are identified, developed, and brought to market. By leveraging advanced algorithms and vast amounts of data, AI is enhancing the efficiency, accuracy, and

Why Outsourcing is Key to the Future of Drug Development

COVID-19 showed us the importance of improving the speed to market of new drugs such as vaccines. And with more challenges facing the industry than ever before, fast and reliable drug development has never been more vital.

Deep Molecular Profiling to understand the biology of Alzheimer disease

AoS. Deep Molecular Profiling to understand the biology of Alzheimer disease

Alzheimer disease (AD) is a complex, polygenic disease with genetic, cellular, pathologic, and clinical heterogeneity. Advances in high-throughput sequencing and omics technologies have accelerated the drive toward personalized medicine. Human bio-specimens using these high-throughput platforms have emerged

Social-economic factors predict state differences in opioid overdose rates

Media accounts of the opioid overdose epidemic emphasize the role of prescription drugs and, to a lesser extent, declining economic and social conditions. In support of the journalists’ accounts, opioid prescriptions, as measured in grams of morphine

Eavesdropping on cell communications to treat cancer with drug resistance

An estimated 19.3 million new cancer cases and almost 10 million cancer deaths occurred worldwide in 2020. It’s estimated that one in three individuals will be diagnosed with some kind of cancer in their lifetime. When cancer

Perspectives for anti-tuberculosis therapy with additional drug activities to counteract drug resistance

AoS. Perspectives for Antituberculosis Therapy with Additional Drug Activities to Counteract Drug Resistance

Generally, antibiotic therapies use single antibiotics to combat sensitive bacteria. The standard of antituberculosis therapy includes four antibacterial agents that all have different modes of activities in the initial phase of a tuberculosis infection with mycobacterium tuberculosis.

Cryo-electron microscopy in drug development

AoS. Cryo-electron microscopy in drug development

Cryo-electron microscopy (cryo-EM) is becoming the method of choice in structure determination of membrane proteins and has great potential for structure-based drug discovery (SBDD). Cryo-EM provides high-resolution structural information of a membrane protein without the need for

Nickel free, built-in nanotubular drug eluting stents

AoS. Ni-free, built-in nanotubular drug eluting stents

Coronary Artery Disease is a common cause of heart failure. Coronary Artery Disease (CAD) is caused by the accumulation of lipids and fats within an injured arteries’ walls and restricts the blood flow to the heart muscle

Adverse Drug Reactions: power, harm reduction, regulation and the ADRe profile

AoS. Adverse Drug Reactions.

Patients should be checked systematically to ensure that they are not being harmed by their medication. Through case studies of prescriptions of antipsychotics to older adults in the UK, we have shown that if healthcare professionals systematically

Novel drug treatment for human infection with H7N9- avian influenza A

Distribution of Avian Influenza A(H7N9) virus infection in China. AoS

The H7N9 subtype of avian influenza is an enzootic and airborne virus which caused an influenza outbreak in China. Infected individuals mostly worked with poultry, suggesting H7N9 virus-infected poultry as the primary source of human infection. Significantly

Tumor regression in a high-mortality mouse pancreatic cancer (xenograft) model with aminosteroid RM-581

Chemical representation of aminosteroid derivative. Atlas of Science

Pancreatic cancer is classified as a high-mortality cancer with a five-year relative survival rate of only 9%. Although most cancer type survival rates have improved over the past decades, pancreatic cancer morbidity has been stable, which illustrates

Production techniques for the development of sub-micron size polymeric drug delivery formulations evaluated

Studied for the production of sub-micron size PLGA particles. AoS

Polymeric drug delivery formulations containing active pharmaceutical ingredients (APIs) offer the advantages of improved stability, targeted delivery and controlled release of APIs in vivo, which can reduce drug burden while enhancing efficacy. Poly(lactic-co-glycolic acid) (PLGA) is amongst

Suicide and drug overdose mortality in Australian young males as a socioeconomic malady

Suicide and drug overdose mortality in Australian young males. AoS

When mortality trends in Australian young adult (20–34 year) males are analysed over 1979–2011, some interesting features emerge. First, a decline in motor vehicle accident mortality by half between 1980 and 1998 did not translate into reduced

Should we think that neem gum polysaccharide and their semi-synthetic derivatives can be utilized as carrier for nanoformulation

Schematic diagram to show the method of nanoparticle formulation. AoS

One of the major concerns related to the newly synthesized drug is poor water solubility, which seems to be a major concern for the pharmaceutical manufacturer and also a rate limiting step in the bioavailability. In this

How we can curb deaths from heroin use

Evidence from many countries shows an alarmingly high death rate amongst former prisoners with histories of heroin addiction in the two weeks following their prison release. A heroin overdose is the most common cause of death in

Heparan sulphate; inspiration for new leishmaniasis drugs

Heparan sulphate. AoS

Leishmaniasis is a group of tropical parasitic diseases caused by infection with the protozoan parasite Leishmania and is endemic in 98 countries, with approximately 2 million new cases annually. Infection occurs when someone is bitten by an

Rethinking drugs’ development in acute heart failure?

The ten drugs developed in AHF during the last two decades

Acute heart failure (AHF) affects 1-2% of adults in developed countries. It strikes mainly people above the age 60, peeking in those older than 85 (prevalence ~ 17.4%). AHF is a life threatening medical event, with gradual

International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems. Osaka, Japan. September 09-10, 2019

Cientific Group is overpowered to declare its absolute first “International Conference and Exhibition on Pharmaceutics and Novel Drug Delivery Systems”. Pharma Conferences hung on September 09-10, 2019 at Osaka, Japan. Pharmaceutica – 2019 gives a general stage

Cellular stress and AMPK activators including metformin and the anesthetic drug propofol promote restoration of human consciousness

Cellular stress and AMPK activators including Metformin

The neural mechanisms that give rise to human consciousness have been described as one of the greatest and most profound mysteries in all of modern medicine. The use of general anesthetics to induce loss of consciousness (LOC)

Bacteriocin AS-48: a potent drug against sleeping sickness

Graphical abstract about AS-48 activity against Trypanosoma brucei.

African trypanosomiasis has been a historical scourge on the African continent and one of the major causes of poverty. It is responsible for sleeping sickness in humans (HAT), and it avoids the development of agriculture based on