Tag Archives: drug
Unmet clinical needs in the treatment of systemic fungal infections. Reformulating repurposed drugs such as amphotericin B
A recent increase in the frequency of fungal infections has led to a higher number of fungal species that can cause these pathologies, as well as a decrease in the number of effective treatments against them due
Biodegradable microparticles used to prolong drug release to inhibit inflammation in osteoarthritis
Articular cartilage is located on the surfaces of the bones in the synovial joint. It protects the underlying bones from damage and shock, but also functions as a lubricant for frictionless movements of the human body. Damage
How does phenobarbital, a therapeutic sedative, activate a nuclear receptor through phosphorylation?
Steroid hormones activate a family of nuclear proteins called nuclear receptors to regulate every aspect of human physiology, reproduction, development, differentiation, metabolism and immunity. A nuclear receptor molecule is comprised of two major structural domains; DNA-binding (DBD)
20th-century version of an old pathogen. Drug resistant tuberculosis
Mycobacterium tuberculosis the causative agent of human tuberculosis (TB) is consider the most successful pathogen that could infect (2 billion), induce (10.4 million) and kill (1.7 million) a large number of people around the world. Besides this
Electrically controlled insulin release
Stimuli responsive materials are promising for designing the next generation of drug delivery systems. Such materials would enable drugs to be released on-demand or in response to patient needs, specifically at the target site, minimizing side effects.
Hot or Not – The Heat Shock Factor1 (HSF1) is essential for Candida albicans cellular functioning
The opportunistic human pathogen, Candida albicans hinges on the heat shock factor-1 (HSF1), a client protein of the well-established heat shock chaperone (protein folding helper), HSP90 for proficiently modulating thermal stress response. In addition to its implications
Applying nanopharmacology to obstetrics: A novel targeted drug delivery system for the uterus
Pregnancy is a dangerous period for both the mother and foetus. Being born too early (preterm birth) is the leading cause of death and disease in children <5 years of age, while insufficient uterine contractions during or
Gold-silver nanoparticles instead of traditional diabetic drugs
Recently, we have published a pioneering work on green biosynthesis and complete characterization of gold and core shell silver-gold nanoparticles (AuNPs and Ag@AuNPs) via using green biopolymer in the influence of microwave radiation. These synthesized nanoparticles provide
3rd International Conference and Expo on Drug Discovery & Designing. Vienna, Austria. October 02-04, 2017
Conference Series has taken an initiation to conduct international conference and Expo on Drug Discovery & Designing workshops worldwide . From last 3 years Conference Series has been conducting Drug Discovery & Designing conferences in major continents
Artemisia annua leaves improved solubility of antimalarial drug, artemisinin
Artemisia annua L., also known as Sweet Annie, is a Chinese medicinal herb that produces the important antimalarial drug, artemisinin. Artemisinin is the most powerful antimalarial ever discovered and its derivatives are the main component of artemisinin
Simple mathematical formulas for tracking the number of antibiotic resistance cases globally
In order to continue to live, microbes and germs have found ways to prevent drugs from killing them in the process of curing patients—when the patients ingest the drugs for treatment. Microbes destroying drugs within patients and
Glutathione-responsive co-assembly hydrogel for controllable drug release
Glutathione-responsive nano-vehicles have gained considerable interest because several intracellular compartments such as cytosol, mitochondria, and cell nucleus contain a high concentration of glutathione (GSH, 2-10 mM) tripeptides, which is 100-1000 times higher than that in extracellular fluids
Are less expensive “biosimilar” drugs as effective at treating ankylosing spondylitis?
Ankylosing spondylitis (AS) is a type of arthritis caused by inflammation, in which the main symptom is back pain. When a substance called tumour necrosis factor (TNF) is over-active in the body, it causes inflammation and damage
Can a doughnut-shaped molecule help design new drugs?
Some of the most advanced and modern medicines, such as those used in the treatment of cancer rely heavily on their selective, high affinity targeting of cancerous cells in order to be effective medicine. However, some drugs
Clues for innovative therapies targeting the c-ring of the F1FO-ATP synthase
Increasing evidence points out that the ATP synthase/hydrolase, also known as F1FO-complex, can be the key enzymatic switch between cell life and death. So, the enzyme complex, which bears the task of building most cellular ATP, the
A new drug target for healthful aging
With the aging population of the United States increasing every year, there is an increasing need to develop new therapeutic modalities to provide for healthful aging. Although longevity is generally considered positively in most families, and of
