Tag Archives: endoplasmic reticulum

The protein TMEM147 is a novel regulator of cholesterol homeostasis in human cells

In terrestrial vertebrate animals, cholesterol is a major sterol lipid with multiple, critically important biological roles. In cells, it is a key constituent lipid of the plasma membrane, affecting its fluidity and stiffness and acting as an

4-PBA improves lithium-induced diuresis by attenuating ER stress

The Kidney regulates body water and sodium balance. The kidney produces approximately 180L of primary glomerular filtrate per day in a healthy adult. The major­ity of this filtrate is reabsorbed in the segments of kidney through water

A tug-of-war helps shape membranes inside human cells

Imagine if you had to construct an intricate factory consisting of layered platforms interconnected with long tubes, using Lego pieces. The task would become more complex if this assembly would have to be periodically dismantled and rapidly

Calcium disturbances in Parkinson’s disease

Parkinson’s disease is a common disorder of the brain that affects around 127,000 people in the UK alone. The disease is characterised by the loss of nerve cells (neurons) that control mobility. Symptoms include muscle stiffness, tremor

ER stress: a new molecular target to treat hyperglycemia-induced vascular damage

Endothelium is a thin layer of cells, which covers the inner surface of blood vessels and has a key role in the maintenance of vascular and metabolic homeostasis. Its functions include regulation of vascular tone, inhibition of