Tag Archives: estrogen receptor

What is a SERM and how does it work?

Estrogen receptors (ERα and ERβ) are nuclear receptors that function as ligand-dependent transcription factors. They play a vital role in many physiological functions such as the development and differentiation of the reproductive tract and mammary gland. They

Metabolic reprogramming: from estrogen dependence to self-sufficiency

Breast cancer is the most common cancer in women and, despite significant progress in diagnosis and treatments, incidence has been steadily increasing in the last 40 years. Approximately 70% of breast cancers are characterised by the expression

Discovery of potential anti-breast cancer agents dual targeting ER and VEGFR-2

Breast cancer (BC) is the most common cancer in females worldwide. Among all BC patients, more than 70% are diagnosed as estrogen receptor positive (ER+). Estrogen is the primary female hormone which is responsible for the development

Sexual dimorphism in pituitary prolactin tumors

The pituitary is located in the middle of the skull base, under the brain. This gland weight less than 1 g but its five cell types control growth, lactation and hormonal production by the thyroid, adrenals and