Tag Archives: heart
Keyhole heart valve surgery after previous heart transplantation
Advances in heart transplant techniques and medication that control rejection and infections resulted in improved survival and quality of life. These improved long term outcomes are unfortunately paralleled by a variety of associated coronary-, mitral- and tricuspid
Early sepsis does not stimulate reactive oxygen species production and does not reduce cardiac function despite an increased inflammation status
Sepsis is due to bacterial infection. If it is sustained for several days, it can trigger severe abnormalities of cardiac function which leads to death in 50% of cases. This probably occurs through activation of toll-like receptors
Antithrombotic therapy duration after coronary stenting: finding the sweet-spot with a novel clinical risk score
Coronary atherosclerosis is still the principal cause of morbidity and mortality in western countries, by inducing ischemia or infarction of the myocardium. Percutaneous treatment of atherosclerotic lesions is nowadays the most common form of treatment of such
Why are skeletal muscles not depleted of energy during intense exercise?
ATP is a universal carrier of energy in a form easily accessible for different reactions in the cell. Its hydrolysis to ADP and Pi (inorganic phosphate) drives processes that cannot occur spontaneously and require energy, for instance
A personalised operation to stabilise aortic root aneurysms
Personalised External Aortic Root Support (or PEARS) is the name given to a very specific operation. By taking the exact measurement of the individual person’s aorta from a CT or MRI scan, a replica of their own
Silk patches to repair hearts
The heart is a very sensitive organ. Once it’s “broken”, it doesn’t quite function the same way again. Biologically speaking, a common way of getting your heart broken is when you suffer a heart attack. When the
Depression severity is related to the development of heart disease in previously cardiac health subjects
Depression is a disabling, high-prevalence psychiatric condition. It is well established that depression is linked with physiological changes that can contribute to an unfavorable outcome in cardiac patients. As depressed patients exhibit impairments in the autonomic nervous
Nerves are required to repair the injured heart
Cardiovascular diseases (CVD), such as heart attack, are responsible for approximately 18 million deaths each year, which accounts for more than 30% of all deaths worldwide. CVD is the single greatest cause of death in humans killing
Evaluation of heart rate measurements in clinical studies – Which way to do it right?
100.000 times a day – this is the daily number of heart beats in human beings. This huge workload normally will pass by unobserved in a healthy being, but in a patient with heart disease any alteration
Lymphatic drainage of the heart
Someone once said that each man is his own island. I would make the analogy that our body is a country, where each organ is a city, each cell a building or factory in the city, and
Jurassic siphon
The sauropod dinosaurs were the tallest animals to ever stalk the earth. The fossilised remains of sauropods indicate that some had necks as long as 12 m. Sauropods are often depicted with their heads held high –
Infections in right-sided heart valves often leave doctors with no right answer
A normal human heart has four chambers and four valves. When these valves are working well, they stop blood from flowing backwards and are essential to good heart function. Two valves are in the right side of
Coronary ostoplasty for congenital atresia of the left main coronary artery ostium in a teenage boy
Coronary artery abnormalities are reported as the third largest cause of sudden death in young athletes. Because patients usually do not have any apparent abnormality on medical examination, it is difficult to detect this before some events.
Heart defects before birth: Why are most cases still being missed (and what can we do about it)
Heart defects occur in roughly 1 in 100 live births—far more than any other kind of birth defect. Over the past decade, it has become increasingly clear that babies with major forms of heart disease have must
Obesity enhances the risk of arrhythmia
The heart consists of 4 chambers in mammals. The upper two chambers are atria, and the lower ones are ventricles. Ventricles work as pump to eject blood to whole body. Atria have 2 important roles: 1) to
A better way to measure heart disease risk for an overweight society
Low density lipoprotein (LDL) cholesterol or the “bad cholesterol” is an established measure of cardiovascular risk. LDL particles interact with the lining of the blood vessel and contribute to cholesterol loading in the arterial wall. Continued buildup
Fighting chronic rejection of transplanted organs
In many diseases the only available cure is organ transplantation. However, if the transplanted organ does not derive from an identical twin (which is genetically identical to the recipient) it becomes rejected by the immune system of
The heart’s own acetylcholine important in health and disease
Tissues and organs of our body are under the control of active chemical compounds. Hormons are released from endocrine glands and reach the targets with blood. Transmitters are released from the endings of nerve fibers. If the
Melatonin reduces blood pressure and tunes up disrupted circadian rhythms in the seniors
The older we get the more likely our circadian rhythms are disrupted. For example, blood pressure not only tends to increase but as well become more irregular. Luckily, as we show here, melatonin helps to ameliorate both
A transcriptomic approach for cardiac (heart) safety assessment
New drug discovery relies on several phases of safety assessment. One such prominent in vitro safety assessment assay is the “hERG potassium channel assay” for cardiac safety. If a compound blocks the hERG potassium channel in a
