Tag Archives: HIV

Metformin and AMPK link cancer stem cell elimination with the potential eradication of HIV

Cancer stem cells (CSCs) are cancer cells that exhibit several stem cell-like qualities that are characteristic of embryonic or adult stem cells, including self-renewal, differentiation, and the ability to initiate tumorigenesis. CSCs, similar to adult stem cells

The community-based management of child malnutrition in Zambia

Acute malnutrition (wasting) remains a major global public concern and a public health priority in Sub-Saharan Africa, especially in countries where high prevalence of HIV/AIDS infection and food insecurity coexist. There are two forms of acute malnutrition:

A novel and quick method to study the drug resistance in reverse transcriptase (RT) of HIV

Human immunodeficiency virus (HIV), a retrovirus, was discovered independently by Luc Montagnier and Robert Gallo in 1983. As per the WHO report of 2015, globally, around 40 million people are infected with this virus. HIV is an

What do African new settlers in New Zealand ‘know’ about HIV?

The aim of this paper is to demonstrate the differences between objective and operational knowledges of HIV transmission, that is, between what people say they know, and what they put into practice in their lives. We are

A pill a day to prevent HIV? Successes and challenges of pre-exposure prophylaxis in the real world

Pre-exposure prophylaxis (PrEP) is a pill composed of two antiretroviral drugs (tenofovir disoproxil fumarate and emtricitabine, or TDF/FTC) that prevents HIV infection. Numerous studies have now shown that when taken daily, this medication has the potential to

Locking out HIV from human cells: a new powerful approach

Picture your home, the safest place in the world. And now imagine a criminal that wants to enter and become you home landlord. And imagine that the criminal has the key. What would you do to protect

What is needed to eliminate new HIV infections in children?

Prevention of transmission of HIV from mothers to infants has become a preventable disease in most western countries because of the use of effective HIV treatment called antiretroviral therapy (ART) that HIV positive pregnant mothers use.   However,

A rare and insidious brain vessel disorder in children with HIV infection

Over the last decade children who acquire HIV infection from their mothers are surviving longer due to improved access to health care, nutritional support and antiretroviral therapies (ART). As they live longer, complications which were previously not recognised in

Immunogenicity of Virus Like Particles (VLP) with modified envelope (Env) protein

HIV uses a special strategy to evade the immune system during the course of infection in a human, based on features of envelope protein.  The HIV Env glycoprotein that forms spikes on the surface of virus particles

HIV/AIDS-associated tryptophan depletion as part of the influence of inflammatory mediators on general nutritional status

The essential amino acid tryptophan cannot be synthesised in the body and must be acquired through dietary intake. Tryptophan is an important substrate for protein synthesis and for synthesis of the neuroactive substances serotonin, melatonin and tryptamine.

Mobile phones support palliative care services in Africa

The African Palliative Care Association (APCA) are a pan-Africa advocacy and research organisation working to expand palliative care services in the Africa region. APCA have been working with Honexus, a software development company, to create an electronic

Prevalence of HIV, hepatitis B and C virus infections among candidates for orthopedic trauma surgeries

Infectious diseases are diseases caused by bacteria, virus or fungus micro organism and very readily given by one person to another. These diseases especially those that are transmitted via human blood and cause disease in humans include,

An “appealing” small virus

In 1975 in London , an australian researcher, doctor Yvonne Cossart has detected by immunological procedures a new virus in the serum of a blood donor; the name of the blood pocket was B19 so this virus

Placental transfer of the HIV drug dolutegravir in a human ex vivo perfusion model

The fetus of an HIV-positive woman has a 25% chance of becoming infected during pregnancy. HIV medicines have shown to be highly effective in preventing fetal infection with HIV. A part of the efficacy but also the

A factor that regulates the expression of HIV genes

Proteins are the machinery of life. Nearly everything in a cell is manufactured by, regulated by or composed of proteins, which are encoded in genes. When a cell needs a particular protein, the DNA encoding the protein

Urine lipoarabinomannan assays for paediatric tuberculosis

Tuberculosis is one of the most common infectious diseases worldwide with 2 billion people being latently infected and 9 million people diagnosed with active disease every year. Infection with TB is also a major contributor to childhood

Kenyan men’s fears about family planning

Despite increases in recent years in the number of women wanting to avoid pregnancy, the use of modern contraceptives in sub-Saharan Africa remains low. For example, in Kenya about three-quarters of married women aged 15–49 want to

A new general principle of virology

Shin et al describe for the first time a novel strategy used by persistent viruses to temporally regulate expression of the structural proteins that make up their virus particles. The viruses that infect humans and other mammals

Computational refinement and validation protocol for proteins

HIV protects itself using a membrane layer of lipids which covers all proteins which could potentially be targeted by drugs. The only exposed proteins, gp120 and gp41 form spikes that protrude out of the lipid membrane.  These

On their way out: Structural HIV proteins team up before escaping from infected cells

The human immunodeficiency virus ( HIV ) infects and eventually destroys the immune cells of infected patients. This causes the life-threatening medical condition called acquired immunodeficiency syndrome ( AIDS ). A cure for HIV/AIDS does not exist,