Tag Archives: human disease
Improving assessment of arthritis models to better reflect human symptoms of disease
Rheumatoid Arthritis (RA) is a common inflammatory disease that is characterized by swelling and tenderness of multiple joints. The resulting pain and joint stiffness cause disability for patients and treatment to control the inflammation is required to
Intracranial injections and animal models: towards understanding and treating human disease
The use of laboratory animals helped us to better understand a myriad of biological processes in health and disease and enabled the development of therapies that effectively cure, or ameliorate life conditions of, millions of people every
Upstream open reading frames (uORFs) as translational regulators in human disease
The messenger RNA (mRNA) translation process is a key step of gene expression, whose regulation allows the cell to rapidly change protein synthesis in a spatio-temporal manner in response to different stimuli. Translation comprises four steps –
Nonsense-mediated mRNA decay (NMD): a bifunctional mechanism in human physiology and disease
Proteins are the working-units of the cell, which are encoded by thousands of genes that pass their information into an intermediate molecule, the messenger RNA (mRNA). For this flow of information – from genes to RNA (transcription),
The combustion of food occurs at cytochrome c oxidase
Cytochrome c oxidase represents the enzyme where cell respiration takes place. The oxygen which we inhale is transported via the blood stream to all cells of the body where it is converted into water by a cold
