Tag Archives: hydrogen bonds

Short hydrogen bonds in proteins and their quantum mechanical nature

The assembly of linear polypeptide chains into functional three-dimensional protein architectures involves a unique force called hydrogen bonding. A typical hydrogen bond forms when the donor and acceptor groups approach each other with a nearly linear geometry

Transcience in enzymes

Protein-enzymes catalyze most biochemical processes through high-energy, transient intermediates. Structural characterization of intermediates can lead to stable analogs that inhibit cognate enzymes and serve as pharmaceutical agents. The enzyme pyruvate dehydrogenase catalyzes the oxidation of pyruvic acid to