Tag Archives: imaging
Gas types affect stability of microbubbles and ultrasound mediated brain-targeted drug delivery
Ultrasound (US) is used for clinical diagnosis and therapy. Microbubbles (MBs) as US-contrast agents are applied to detect micro blood flow or specific lesions. Recently, the combination of MBs and US has received much attention for drug
In vivo 2-color multiphoton imaging of genetic reporter fibroblasts in the skin
Fibroblasts are cells that synthesize collagen and support the maintenance of connective tissue in the skin, tendons, and joints. They maintain a critical role in the immune system’s response to tissue injury by promoting wound healing at
Unlocking the gating mechanism of the piezo1 channel with a molecular key
Mechanosensitive Piezo channels are large membrane proteins present at the cell membrane of eukaryotic cells. These channels open in response to the presence of mechanical forces such as frictions that occur when extracellular fluids flow against the
Routine imaging in patients with follicular lymphoma in remission
B-cell lymphomas are a heterogeneous group of malignancies originating from B lymphocytes. Modern day chemotherapy is effective in inducing disease remission in a large percentage of patients for most of the subtypes. Some of these subtypes, the
Toward more accessible PET imaging: Miniaturizing the last step of radiotracer preparation
Positron emission tomography (PET) is a 3D body imaging method for visualizing dynamic biochemical processes in living subjects with unparalleled specificity and sensitivity. PET scans, often performed together with CT or MRI imaging, are used clinically to
FTIR spectroscopy and ımaging to understand donor age effect on bone marrow mesenchymal stem cells
Stem cells, like Bone Marrow Mesenchymal Stem Cells (MSCs), have enormous potential to develop new therapies for tissue regeneration and repair with their ability to differentiate into many different types of cells. The aging process and the
Do you want a specific signal? Go local! Imaging our way to targeted therapy
Cyclic adenosine monophosphate (cAMP) is a ubiquitous intracellular second messenger, a small molecule that conveys the information carried by hormones, neurotransmitters and other extracellular stimuli to the intracellular environment. cAMP is generated at the plasma membrane when
Biological applications of Brewster angle microscopy
Brewster angle microscopy (BAM) is an imaging technique that allows for the visualization of the film architecture of monolayers without the use of exogenous dyes. This is a relatively new system that was developed independently and concurrently
Transmitted sound wave mammography
This study was designed to look at a new type of totally harmless breast imaging called whole-breast transmission ultrasound to see if it could do something mammography cannot do – that is to diagnose the presence of
A potential radiotracer for imaging the lungs
Routine patient lung scans in the nuclear medicine department have for decades, employed a radioactive technetium-99m-aggregated-albumin particle injection dose, in conjunction with a ventilation dose of Tc-99m-aerosol in tandem. The lung scans are usually requested for patients
An organic gas instead of inorganic gases for the enhancement of 129Xe magnetic resonance signals through optical pumping
Several new methods have been developed in these two decades in nuclear magnetic resonance (NMR) spectroscopy, which make us accessible to weak signals hitherto unmanageable because of the low sensitivity. Among them, spin-exchange optical pumping (SEOP) can
Ankylosing spondylitis: what you should know about spinal fractures
The aim of this review article was to provide the required clinical knowledge that radiologists need to know and the relevant radiological semiotics that clinicians require in diagnosing clinically significant injuries to the ankylosed spine. Ankylosing spondylitis
Lung cancer imaging before surgery and the role of brain MRI
Lung cancer kills more people each year than any other cancer worldwide. The best chance at curing the cancer is with surgery, however not all lung cancers can be taken out. Surgeons use a variety of imaging
Acute stroke in 3 brain territories suggests cancer
Over the past several decades cancer has increased to rival heart disease as the leading cause of death in the United States. Non-infectious endocarditis and cancer-associated hypercoagulation (C-AH) have both been suggested as a source of stroke
High content nanotoxicological screening using Raman spectroscopy
In recent years, the potential use of nanomaterials as novel agents in a wide range of areas, from industrial applications to Nanomedicine, has drawn attention to investigation of their toxicological properties. From their production, to use and
Non-invasive whole-body imaging of fibrosis: is it feasible?
Fibrosis is a chronic, life-shortening disease that can occur either as a consequence of genetic defects or in response to inflammation or damage. Such body systems as respiratory, gastrointestinal, musculoskeletal, genitourinary, and reproductive can be affected. Fibrosis
Can imaging of improve our understanding of cardiovascular disease?
The development of new ways for imaging the heart has contributed significantly to our understanding of cardiovascular disease. Combined positron emission tomography and computed tomography (PET-CT) allows us to visualize in great detail the anatomy of the
Visualizing gelsolin amyloid with nanobodies; small molecules with big potential
Amyloidosis is a group of diseases characterized by the deposition of aggregated proteins, or protein fragments, in tissues and organs. The diseases differ from each other in the causative protein, but once aggregation starts, they all result
Chiari malformations and syringohydromyelia in children
More than 100 years ago, Hans Chiari, an Austrian pathologist, described different types of morphological abnormalities of the posterior fossa, the small space in the lower part of the skull just above the spinal canal. The brainstem
Zika virus infection during pregnancy and small heads: What is the connection and what can be seen by imaging
Within the last year, the outbreak of Zika virus infection in Brazil became a “public health emergency of international magnitude and concern”. The global discussions about the risk of Zika virus infection for pregnant women ahead of
