Tag Archives: immune response
miR-146 and miR-155, two key modulators of the immune response and of the oncogenic transformation
Micro-RNA (miRNAs or miRs) are small noncoding RNAs that negatively regulate protein coding gene transcripts and exert an important role in the control of gene expression. miRs are deregulated in many tumors and play an active role
Glycans to reprogram the immune response
Glycans are structures composed of sugars or carbohydrates, which are highly abundant on all cells. These molecules serve many functions, including binding and communication between cells, movement of cells and maintenance of tissue structure. Glycans are crucial
Role of the gut in systemic inflammation
The multi-layer wall of the intestine is unique and important due its barrier function for billions of potential deadly gut bacteria and the sterile tissues in the body. For this reason, the intestine is equipped with highly
Steroid hormones regulated the cellular immune response of the crustacean
The endocrine system plays a crucial role in metabolism. Endocrine – secreted materials regulate the growth , development, reproduction, and immune response of organisms. In crustaceans , steroid hormones have been synthesized by feeding cholesterol as the
Metal ions are a promising tool for Regenerative Medicine?
Ions play a vital role in living systems because cells use ions to accelerate chemical reactions, to synthetize biologic molecules or as messengers. The transport of oxygen through the blood is possible due to the iron ion
Quorum sensing concept shed new lights on the collective regenerative behavior through study of hair plucking
Scientists know injuries sometime induce regeneration sometime not. Scientists search for factors that can promote regeneration. Usually, regeneration process is studied by analyzing the regenerative behavior of one organ unit. However, this may not be sufficient to
How the immune system is regulated by small RNAs called microRNAs to prevent self-attacks leading to autoimmunity
The ability to properly engage the different arms of the immune response is essential for protection from pathogens but also for preventing autoimmune reactions against normal tissue. Central to autoimmune prevention are a class of white blood
Pancreatic cancer and innovative treatment: the seeming paradox to block the immune response
Pancreatic cancer (PC) is the 5th leading cause of cancer‐related death in the developed world with more than 260,000 annual deaths worldwide and with a dismal 5‐year survival (5%). The lethality of pancreatic cancer is due to
Impact of Influenza A virus PA-X protein on host immune responses
Influenza A virus is a clinically important respiratory pathogen that annually infects millions of people worldwide and is, therefore, a serious threat to public health. Recurrent influenza infections occur throughout life because a relatively weak immune response
Demyelination and remyelination signalling in multiple sclerosis as an aid to targeted therapy
Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system (CNS) characterised by demyelination. Demyelination, i.e. damage and erosion of the myelin sheath which protects the nerve fibres, occurs in the white matter of
