Tag Archives: immune
Ultrasensitive enzyme immunoassay by immune complex transfer method
Many technologies have been developed to improve the sensitivity of immunoassays, such as high affinity antibodies, specific conjugations using the hinge region of Fab’ fragments, highly active enzymes, and digital counting systems. We described a methodology called
Unsightly war zones of aging
Imagine you were trying to hammer a nail, but instead you accidentally hit your thumb. Aside from pain, you may notice redness, swelling, and warmth of your thumb. These are symptoms of inflammation. When an area of
Glycans to reprogram the immune response
Glycans are structures composed of sugars or carbohydrates, which are highly abundant on all cells. These molecules serve many functions, including binding and communication between cells, movement of cells and maintenance of tissue structure. Glycans are crucial
Activation: a double-edged sword for Treg
Regulatory T cells (Tregs) are a specialized subset of T cells. As the name suggests, they play a role in controlling and regulating other immune cells. Tregs, characterized by the expression of the forkhead/winged-helix transcription factor Foxp3,
A new kind of human immune cell that cannot leave the liver
Natural Killer (NK) cells are immune cells that are found in the blood and protect the body by killing infected and cancerous cells. NK cells can also be found in large numbers in some organs, including the
Surrogate endpoints for overall survival in lung cancer patients treated with PD-1/PD-L1 blockade
Anti PD-1/PD-L1 antibodies are becoming key therapies in the treatment for advanced non-small-cell lung cancer (NSCLC). Surrogate endpoints for overall survival (OS) such as tumor response and progression-free survival (PFS) are useful to detect drug efficacy earlier,
