Tag Archives: inflammation

Could mometasone furoate be a viable glucocorticoid with fewer metabolic adverse effects?

AoS. Could mometasone furoate be a viable glucocorticoid with fewer metabolic adverse effects?

Glucocorticoids are medications widely used to treat inflammation and allergies, and in contexts of immunosuppression such as after transplants. They are well-established and safe. The problem is that, when used for a long time, or in high

Galectin-9: A new target for beating atherosclerosis?

AoS. Galectin-9: A new target for beating atherosclerosis

Atherosclerosis is a chronic medical condition characterised by the accumulation of fat in the walls of blood vessels, which obstruct the normal flow of oxygen-rich blood and can have severe health consequences. Peripheral arterial disease (PAD) is

Improving assessment of arthritis models to better reflect human symptoms of disease

AoS. Improving assessment of arthritis models to better reflect human symptoms of disease

Rheumatoid Arthritis (RA) is a common inflammatory disease that is characterized by swelling and tenderness of multiple joints. The resulting pain and joint stiffness cause disability for patients and treatment to control the inflammation is required to

Role of dopamine in cortico-basal ganglia loop in psychosis

Dopamine plays a major role in the formation of acute psychosis, as indicated by the dopamine hypothesis of schizophrenia. The relationship between acute psychosis and the dopamine system provides insight into the effects of dopamine on brain

The complementary anti-inflammatory and anticancer activity of hydroxycinnamic acid derivatives

AoS.The complementary anti-inflammatory and anticancer activity of hydroxycinnamic acid derivatives

Inflammation is an important and extremely complex biological process involving a high number of mediators responsible for the activation of multiple cascades, providing a wide range of possible targets for the pharmacological treatment of inflammatory-related diseases. It

Satiated macrophages produce interferon-beta to orchestrate the resolution of bacterial infection

Acute inflammation is a localized, self-limited host defense mechanism against invading microorganism and tissue injury. Rapid recruitment of white blood cells called neutrophils (polymorphonuclear neutrophil granulocytes) from the blood to the site of infection or injury is

The suitability of scopolamine as an Alzheimer’s model

AoS.The suitability of scopolamine as an Alzheimer’s model

Alzheimer’s disease is the most common cause of dementia. About 50 million people worldwide have Alzheimer’s disease or a related form of dementia. Alzheimer’s disease is a terminal illness affecting mostly the elderly above the age of

Inflammatory differences between men and women uncovered by 27-hydroxycholesterol

Inflammatory differences between men and women uncovered by 27-hydroxycholesterol. AoS

The combination of reduced exercise and increased caloric intake has led to a global obesity epidemic. Besides being characterized by increased waist circumferences and BMI, many obese patients also suffer from a chronic, low-grade inflammatory response, which

More than your average bread spread: plant stanols as therapeutical tool in Niemann-Pick type C1 disease

Niemann-Pick type C1 (NPC1) disease is a lysosomal storage disease that affects nearly 1 in 100,000 live births worldwide. NPC1 disease is caused by mutations in the NPC1 gene that result in a dysfunctional NPC1 protein, which

Does intestinal inflammation impact the lung response to bacterial endotoxin?

Lung inflammation leading to airway hyperresponsiveness causes illnesses for more than ten percent of the population in USA. Recent research had indicated that patients with inflammatory bowel disease have higher incidence of airway hyperresponsiveness compared to the

Biomarkers for Alzheimer’s disease diagnosis: an eye on retinal inflammation

Biomarkers for Alzheimer’s disease diagnosis. AoS

Alzheimer’s disease is one of the most common neurodegenerative disorders. Alzheimer’s disease cases are constantly increasing worldwide due to population aging. Typical symptoms of the disease include memory loss, cognitive deficits, personality and behavior modifications. At the

Analysis of serum biomarkers and their correlation with pain and quality of life in the rare disease alkaptonuria

Analysis of serum biomarkers and their correlation with pain

Alkaptonuria (AKU) is an ultra-rare disease causing an early onset, chronically debilitating spondylo-arthropathy due to deposition of an ochronotic pigment in joints and spine, which causes severe pain and greatly reduces patients’ quality of life. Despite an

Treatment of experimental eye inflammation with a single subconjunctival injection of liposomal steroid

Treatment of experimental eye inflammation

Non-infectious anterior uveitis is an inflammatory condition in the front of the eye that can potentially lead to blindness. The current gold standard for treatment is with steroid eyedrops.  However, this treatment has several disadvantages. Very little

Inhibitors of intracellular enzymes for treatment of multiple sclerosis

The protein kinase inhibitor imatinib

Lymphocytes are white blood cells that are central in the immune response to foreign microorganisms. Like all cells, lymphocytes have a membrane, a lipid bilayer, that envelops the content of the cell. Proteins attached to the cell

Unsightly war zones of aging

Unsightly War Zones of Aging

Imagine you were trying to hammer a nail, but instead you accidentally hit your thumb. Aside from pain, you may notice redness, swelling, and warmth of your thumb. These are symptoms of inflammation. When an area of

Fibroblasts in rheumatoid arthritis: From friend to foe

Fibroblast effects on leukocytes

Our joints are composed of tissue-resident cells, called fibroblasts, which are responsible for maintaining the structure of the joint and repairing damaged tissue. Additionally, we and others have shown that fibroblasts can also influence the types and

Fungal chitin treatment reestablishes the anaerobic bacteria and decreases the intestinal inflammation in mice

The gastrointestinal (GI) microbiota acts a natural barrier to colonization and proliferation of opportunistic pathogens, thereby decreasing the risk of intestinal infection and disease. Deregulation of the dynamic crosstalk between the microbiota, intestinal epithelial cells and immune

Macrophages in atherosclerosis; the good, the bad and the foamy?

Atherosclerosis is a chronic inflammatory condition in which arteries are narrowed due to the deposition of plaque material to the artery walls. This narrowing can give rise to other cardiovascular events like thrombosis or a stroke. One

Training the immune system to treat Niemann-Pick type C1 disease

Every year, at least 1 in 100,000 people worldwide is born with Niemann-Pick type C1 (NPC1) disease, a lysosomal storage disease. Lysosomes are cellular compartments which process an array of substrates – from DNA to nutrients –

Polarized light therapy: Illuminating immunity

What is it?: Light has been used as an alternative mode for the treatment of diseases, since the ancient Egyptians basked in the sun to restore their energy. Phototherapies are modern treatments in which light is used