Tag Archives: kidney

Towards organs on demand: a new platform for successful kidney organogenesis

The ultimate treatment for end-stage renal disease is orthotopic transplantation. However, the demand for kidney transplantation far exceeds the number of available donor organs. While more than 100,000 Americans need a kidney, only 17,000 people receive a

Animal-free platforms for the efficient and accurate prediction of kidney toxicity in humans

Tens of thousands of chemicals are used in food, cosmetics and consumer products. In addition, humans are exposed to drugs and environmental toxicants. Safety testing based on animals is too slow and too costly for screening the

Should we use gentamicin cream to prevent exit-site infection in peritoneal dialysis?

Peritoneal Dialysis (PD) is one of the treatment modalities for kidney failure. With PD, the toxins from the blood are removed through the abdominal membrane (peritoneum) into the fluid, which is put into the abdomen through a

Treatment holidays for patients with metastatic kidney cancer

Targeted therapy is the standard treatment of patients with metastatic cancer of the kidney. The best current therapies target the tumour vasculature thereby blocking the access of the tumour to nutrients and limiting possibility of spreading to

Renal cell carcinoma: can we identify patients with advanced disease?

Kidney cancer is among the 10 most common cancers in both men and women with approximately 61,560 new cases and 14,080 deaths from this disease expected in 2015. Clear cell renal cell carcinoma (ccRCC) is the most

Does acute kidney injury affect other organs?

Acute Kidney Injury (AKI) is a common and serious condition with no specific treatment. AKI has been estimated to cost the NHS in the UK alone between £451-626 million per year. Recovery from a single episode of

AZGP1, a new candidate for the treatment of chronic kidney disease

In elderly populations, chronic kidney disease is a common clinical problem associated with a high degree of morbidity and mortality. When the kidney is injured by, for example, low blood flow, the human body has a remarkable

“Nothing to worry about”? The meaning of a Chronic Kidney Disease (CKD) diagnosis for patients put on a disease register

We interviewed a group of people who had been recruited to a trial for people with early stage Chronic Kidney Disease (CKD). The wider trial was concerned with finding out whether helping people with early stage CKD

CKD affects mortality in TAVI patients

Aortic stenosis (AS) is the most frequent type of valvular heart disease in Europe and North America. It primarily presents as calcific AS in old people (2–7% of the population > 65 years). Calcific AS is a

Modulation of bad cholesterol: what happens when patients with kidney disease receive omega-3-fatty acids?

Just as oil cannot dissolve in water, so cannot fat dissolve in blood. In order for our bodies to transport cholesterol, which is made of fat (lipids), within our bloodstreams something is needed to carry it around.

A way to a man’s (or women’s) kidney is through the stomach

Kidney cancer can be difficult to diagnose. A biopsy may be needed. Kidney biopsy is usually taken by passing a needle from the outside of the patient into the kidney. The needle is passed from the patient’s

Kidney angiotensinogen as a cardinal risk factor in hypertension

High blood pressure is prevalent in over 30% of the adult population and accounts for approximately one fourth of patients with heart failure, especially the elderly. The renin-angiotensin system (RAS) is of critical importance in the regulation

Advanced green antibacterial materials made by mussel-inspired chemistry

Since ancient times, silver and its salts have universally been employed as antibacterial agents for the treatment of infections, burns and chronic wounds in curative and preventive health care, because of their extraordinary inhibitory and bactericidal properties

Fully human anti-CAIX antibodies for RCC immunotherapy

Globally, there are roughly 270,000 new cases and 116,000 deaths attributed to kidney cancer occur each year. More than 90% of kidney neoplasms are classified as renal cell carcinoma (RCC), which accounts for 3% of all adult

Renal risk associated with sodium phosphate medication

Sodium phosphate drugs (solutions, tablets or enemas) are used since 1990s as laxatives for bowel cleansing before endoscopy and radiology examination, or occasionally for treatment of severe constipation. Sodium phosphate drugs are low-volume osmotic purgatives, their administration

Kidney disease dramatically affects whether patients should undergo vascular interventions

Kidney disease is a significant risk factor for poor outcomes following vascular surgery, and should be taken into consideration when evaluating patients for elective vascular interventions. Patients with kidney dysfunction who are recommended intervention by a vascular

CRIC: studying the silent epidemic of kidney disease

Chronic kidney disease (CKD) is a public health problem affecting more than 20 million Americans, and far more worldwide. Although CKD typically begins with no noticeable symptoms, it is a progressive disease which if untreated often leads

Onco-Nephrology: the frontier of cancer and kidney disease

Kidney problems can result from cancer or its treatment. Patients with kidney disease can develop cancer. These clinical problems are challenging and significantly affect morbidity and mortality. Yet until recently they have not had focused attention. Cancer

Why do older people get so much kidney disease?

To celebrate Sir William Osler’s 70th Birthday on July 12th 1919 his pupils and co-workers contributed scientific articles that were collected and published. One of these articles, by William Councilman pathologist-in-chief at Peter Bent Brigham Hospital, noted