Tag Archives: leukemia

A DNA repair gene, OGG1, polymorphism affects relapse risk of acute myeloid leukemia

A DNA repair gene, OGG1, polymorphism affects relapse risk of acute myeloid leukemia

Approximately 80% of acute myeloid leukemia (AML) patients can achieve complete remission, but around half of them relapse within five years. Defining the mechanism of relapse is essential to improve the prognosis of AML. Recently, a clonal

IL-2/IL-3 interplay mediates growth of CD25(+) acute myeloid leukemia cells

acute myeloid leukemia cells

A variety of cytokines regulate the survival, growth, differentiation and apoptosis of leukemia cells. Accordingly, aberrant or excessive expression of their receptors may be associated with the biological activity of leukemia cells, and hence with the outcome

What it takes to survive a transplant

Many patients with blood cancers, such as multiple myeloma, leukemia, or lymphoma, have radiation treatment or chemotherapy to destroy their tumor cells and diseased bone marrow. Unfortunately the treatment damages their immune system leaving them immunocompromised. To

Too hard to defeat Devils

Hematopoietic cell transplantation (HCT) offers potentially curative therapy for patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). However, relapse following HCT is considerable and becomes a major cause of failure in patients with MDS and AML.

Chronic lymphocytic leukemia (CLL) diagnostics better to do in cultivated than native cells

Cancer is an age associated disease. In Western countries with people having longer life expectancies than e.g. 100 years ago, this means at present that 1-2% of those individuals are confronted with the diagnosis of leukemia during

Long-term survival of donor multipotent mesenchymal stromal cells implanted into the bone

There are two types of stem cells in the bone marrow, one for the formation of blood cells and another for the formation of the skeleton and the bone marrow stroma. Stromal cells (5% of all cells

STAT3: The double edged molecular sword in Chronic Lymphocytic Leukemia cells

The common denominator of different types of cancers is an ever expanding clone that originates from a single cell. In acute leukemia the clonal expansion may be very rapid and the clone double its size sometimes within

Loss of Trpm2 does not potentiate standard acute myeloid leukemia chemotherapy

Leukemia is a cancer of the blood that affects thousands of people of all ages (including children and even babies). Treatment is very toxic, and often fails to cure patients. Leukemia is caused by mutations in specific

Proteome view on how leukemia cells communicate with their environment to escape chemotherapy

Relapse continues to pose a major challenge to successful chemotherapy of adult acute myeloid leukemia (AML). Even though 80% of AML patients achieve remission, in which the bone marrow is virtually clear of leukemic cells, still almost

“Good kids in bad neighborhoods” – the role of bone marrow microenvironment in the development of acute myeloid leukemia

Acute myeloid leukemia (AML) is the most common and aggressive blood cancer in adults and is associated with a high rate of mortality due to cancer therapy resistance and disease relapse. AML is characterized by severe deficiency

Risk modifier(s) of susceptibility to pediatric acute lymphoblastic leukemia

Acute Lymphoblastic Leukemia (ALL) is an acute form of cancer of the white blood cells, characterized by the overproduction and accumulation of immature precursors known as lymphoblasts. ALL is the most common type of leukemia in children

Focusing on non-tumor-derived factors for leukemia therapy

Approximately 10-20 million people worldwide are estimated to be infected with human T-cell leukemia virus type I (HTLV-I), and 1-3% of HTLV-I-infected individuals develop a cancer of CD4+ T lymphocytes in the blood each year.  The retrovirus-associated

CML – where do we stand in 2015?

The progress with CML‐treatment continues at a rapid pace. Treatment of choice is targeted therapy with tyrosine kinase inhibitors (TKI). Five‐year survival ranges around 91% and 10‐year survival around 84% up from 11% with Busulfan 30 years ago. More

Leukemia cells rely on vesicles from neighboring stromal cells to resist common cancer treatments

Leukemia is a cancer of white blood cells that occurs in both children and adults.  Strides have been made in curing most types of leukemia.  However, acute myeloid leukemia (AML) continues to resist the same treatment strategies. 

Unlocking trafficking impasse in life-and-death struggle of leukemic cells

Lymphocytes are immune system cells devoted to the defence against enemies coming from both outside (i.e. bacteria and viruses) and inside (tumours). Several times per day these cells escape from the blood and enter into the immune