Tag Archives: leukemia
A DNA repair gene, OGG1, polymorphism affects relapse risk of acute myeloid leukemia
Approximately 80% of acute myeloid leukemia (AML) patients can achieve complete remission, but around half of them relapse within five years. Defining the mechanism of relapse is essential to improve the prognosis of AML. Recently, a clonal
IL-2/IL-3 interplay mediates growth of CD25(+) acute myeloid leukemia cells
A variety of cytokines regulate the survival, growth, differentiation and apoptosis of leukemia cells. Accordingly, aberrant or excessive expression of their receptors may be associated with the biological activity of leukemia cells, and hence with the outcome
What it takes to survive a transplant
Many patients with blood cancers, such as multiple myeloma, leukemia, or lymphoma, have radiation treatment or chemotherapy to destroy their tumor cells and diseased bone marrow. Unfortunately the treatment damages their immune system leaving them immunocompromised. To
Too hard to defeat Devils
Hematopoietic cell transplantation (HCT) offers potentially curative therapy for patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). However, relapse following HCT is considerable and becomes a major cause of failure in patients with MDS and AML.
Chronic lymphocytic leukemia (CLL) diagnostics better to do in cultivated than native cells
Cancer is an age associated disease. In Western countries with people having longer life expectancies than e.g. 100 years ago, this means at present that 1-2% of those individuals are confronted with the diagnosis of leukemia during
Long-term survival of donor multipotent mesenchymal stromal cells implanted into the bone
There are two types of stem cells in the bone marrow, one for the formation of blood cells and another for the formation of the skeleton and the bone marrow stroma. Stromal cells (5% of all cells
STAT3: The double edged molecular sword in Chronic Lymphocytic Leukemia cells
The common denominator of different types of cancers is an ever expanding clone that originates from a single cell. In acute leukemia the clonal expansion may be very rapid and the clone double its size sometimes within
Loss of Trpm2 does not potentiate standard acute myeloid leukemia chemotherapy
Leukemia is a cancer of the blood that affects thousands of people of all ages (including children and even babies). Treatment is very toxic, and often fails to cure patients. Leukemia is caused by mutations in specific
Proteome view on how leukemia cells communicate with their environment to escape chemotherapy
Relapse continues to pose a major challenge to successful chemotherapy of adult acute myeloid leukemia (AML). Even though 80% of AML patients achieve remission, in which the bone marrow is virtually clear of leukemic cells, still almost
“Good kids in bad neighborhoods” – the role of bone marrow microenvironment in the development of acute myeloid leukemia
Acute myeloid leukemia (AML) is the most common and aggressive blood cancer in adults and is associated with a high rate of mortality due to cancer therapy resistance and disease relapse. AML is characterized by severe deficiency
Risk modifier(s) of susceptibility to pediatric acute lymphoblastic leukemia
Acute Lymphoblastic Leukemia (ALL) is an acute form of cancer of the white blood cells, characterized by the overproduction and accumulation of immature precursors known as lymphoblasts. ALL is the most common type of leukemia in children
Focusing on non-tumor-derived factors for leukemia therapy
Approximately 10-20 million people worldwide are estimated to be infected with human T-cell leukemia virus type I (HTLV-I), and 1-3% of HTLV-I-infected individuals develop a cancer of CD4+ T lymphocytes in the blood each year. The retrovirus-associated
CML – where do we stand in 2015?
The progress with CML‐treatment continues at a rapid pace. Treatment of choice is targeted therapy with tyrosine kinase inhibitors (TKI). Five‐year survival ranges around 91% and 10‐year survival around 84% up from 11% with Busulfan 30 years ago. More
Leukemia cells rely on vesicles from neighboring stromal cells to resist common cancer treatments
Leukemia is a cancer of white blood cells that occurs in both children and adults. Strides have been made in curing most types of leukemia. However, acute myeloid leukemia (AML) continues to resist the same treatment strategies.
Unlocking trafficking impasse in life-and-death struggle of leukemic cells
Lymphocytes are immune system cells devoted to the defence against enemies coming from both outside (i.e. bacteria and viruses) and inside (tumours). Several times per day these cells escape from the blood and enter into the immune
