Tag Archives: mass spectrometry
Monitoring of the consumption of new psychoactive substances in wastewater from Athens
Licit and illicit drug use monitoring is an important subject for public health. Almost every substance that people consume is excreted as parent compound and as metabolites via urine and faeces and ends up in the sewage
A mass spectrometry view of the interaction of Alzheimer’s disease proteins with an anti-aggregation compound
Alzheimer’s disease is a neurodegenerative disease that has been studied extensively over the last four decades. Millions of people worldwide are affected by this disease, and because our population is growing older, this disease is becoming alarmingly
Control of doping in racing pigeons
Pigeon racing is considered a popular sport in several countries such as Belgium, England, Netherlands, Portugal, Japan, Taiwan and South Africa. In all these countries, pigeon racing is a federated sport and racings take place on a
A novel quantitative iron imaging strategy in hereditary hemochromatosis based on LA-ICP-MS
Hereditary hemochromatosis (HH) is the most frequent genetic disorder in Caucasians, which affects about 1 in 1000 people in the Northern European ancestry. It is an iron overload disease with typical clinical symptoms resulting from excess body
Mechanistic details of a copper-catalyzed C-H oxidative cyclization
Exploiting chemical or biological reactions by different spectroscopic techniques has become a powerful method for mechanistic analysis. Such studies enable chemists to understand several reaction features, optimize reaction conditions and yield, develop cost-effective synthetic methodologies, and predict
Ultra Quick sample preparation prior to GC-MS based metabolomics
Metabolomics is a comprehensive study of low molecular weight compounds in biological samples and has been applied to wide range of research areas from medical to food analysis. For the analysis of metabolites, gas chromatography-mass spectrometry (GC/MS)
The T cell IFT20 interactome: new insights into immune synapse assembly regulation by the IFT system
T lymphocytes are key cellular components of the immune system that are essential for the elimination of viral, bacterial and parasitic infections as well as of malignant cells. T cell activation is initiated following recognition of pathogen-
Peculiar pollutants in the Moscow atmosphere in winter period: gas chromatography-high resolution time-of-flight mass spectrometry study
Moscow, Russia is one of the most populated cities in the world, with the metropolitan population reaching 12 million people. Moscow being also an important industrial center has several power plants, multiple industrial factories, waste incinerators, and
Determination of regions involved in amyloid fibril formation for Aβ(1-40) peptide
Mechanisms of amyloid formation of Aβ peptide are studied intensively. Determination of regions responsible for aggregation of the peptide and formation of amyloid fibrils is one of the primary aims in studying the formation of such structures.
Proteome view on how leukemia cells communicate with their environment to escape chemotherapy
Relapse continues to pose a major challenge to successful chemotherapy of adult acute myeloid leukemia (AML). Even though 80% of AML patients achieve remission, in which the bone marrow is virtually clear of leukemic cells, still almost
A new picture for an old biology, HDL as you’ve never seen it before
High-density lipoprotein (HDL) is known as good cholesterol since high levels of HDL are associated with lower risk of cardiovascular disease. Unlike its counterpart, low-density lipoprotein (LDL), whose actions are combatted by statins, clinical outcome trials for
Throwing a wrench into the hepatitis C replication machine
As an essential step in its replication cycle, the human hepatitis C virus (HCV) must make a copy of its RNA genome. The major player in this process is the NS5B polymerase, a molecular machine which uses
Combining paper-based electrochemistry and mass spectrometry
Electrochemistry / mass spectrometry ( EC / MS ) has many applications in science and industry such as drug discovery, elucidation of redox mechanisms, identification of drug metabolites, and online chemical derivatization for improving analytical figures of
Parallel Reaction Monitoring: A targeted mass spectrometry method
Mass spectrometry has emerged as a highly sensitive technique to study proteins and proteomes. Proteome is an entire repertoire of proteins in its various forms present in a cell, tissue or an organism. The study of proteome
Human exposures to Bisphenol A alternatives and derivatives with equal or more harmful effects
Recent years have witnessed an exponential interest in the use and research on bisphenol A (BPA). BPA is one of the chemicals ranked very high in the chemicals’ list with the highest production volume estimates worldwide. BPA
Rapid detection of cocaine in fingerprints using ambient mass spectrometry
Fingerprint residues, commonly referred to as fingerprints, are the result of an accumulation of sweat at the fingertips which is transferred to any surface upon contact. The composition of the fingerprint residue is therefore dependant on the
How to spot a sick cell?
Mass spectrometry (MS) is a technique used to measure the mass of molecules. Chemists extensively use this method to confirm that they have made the right molecule by comparing the mass of the actual product with the
Environmental contaminants as needles in a haystack
Detection of environmentally significant contaminants in very complex mixtures is a challenging problem for analytical chemists. A common approach uses gas chromatography (GC) to separate the mixture components in combination with mass spectrometry (MS) to identify the
Mass spectrometry for characterization of anti-theft devices directly from banknotes
The growth of bank and automated teller machine (ATM) thefts, particularly with the use of explosives, is a serious and increasing crime that has recently doubled in frequency in Brazil. Anti-theft security inks or anti-theft devices (ATDs)
