Tag Archives: metastasis
FLYWCH1 is a novel transcriptional repressor for the cancer-causing Beta-catenin
There is no doubt that cancer is a devastating disease. However, restraining the cancerous cells from spreading throughout the body (invasion) will make it easier to control and possibly cure cancer. β-catenin is one of the proteins
A new biomarker for Triple negative breast cancer MCP-1 drives cancer invasiveness and metastasis
Breast Cancer is the second leading cause of mortality in women in the United States. Breast cancer arise in the ducts of the mammary glands that produces milk in a lactating breast. Breast cancers usually express various
Targeting cholesterol metabolism to suppress prostate cancer metastasis
Metastatic prostate cancer is the second leading cause of cancer death in men worldwide. Prostate cancer itself is one of the most common cancers in men. At the early stages, localized prostate cancer usually grows slowly and
Adopting mammary development gameplay in breast cancer initiation and progression
The process by which the breast changes during puberty and lactation is incredibly unique. Those changes are essential for the functional mammary gland. These changes are triggered and orchestrated by hormones. Such hormonal changes start during pregnancy
Tissue-specific MED1 LxxLL motifs play critical roles in HER2-driven breast cancers
Estrogen Receptor (ER) is a nuclear hormone receptor that plays important roles in normal mammary gland development as well as breast cancer growth and metastases. In a breast cancer setting, when ER is bound by estradiol, there is
RKIP and YY1: The ‘good’ and the ‘bad’ shields in the protection of cancer spreading and resistance to therapies
Cancer originates from all of the uncorrected mutations occurring in the DNA of the cell that lead to abnormal cell growth. Accordingly, the accumulation of these mutations transforms a normal cell into an “immortal” cancer cell with
Treatment holidays for patients with metastatic kidney cancer
Targeted therapy is the standard treatment of patients with metastatic cancer of the kidney. The best current therapies target the tumour vasculature thereby blocking the access of the tumour to nutrients and limiting possibility of spreading to
Diagnosis of small cell lung carcinoma metastases
Cancer is defined by unscheduled cellular growth and metastatic spread into other organs of the body. Tumor cells gain their capacities form genetic alterations, also known as mutations, leading to altered protein functions and signaling pathways. Tumors
How can cancer cells use hydrogen peroxide to strive?
Hydrogen peroxide (H2O2) is a well-known antiseptic used in our homes since the 1920s. But did you know that our cells produce this molecule and that at low concentrations H2O2 instructs our cells to do different things,
CITED1 is a potential therapeutic target for metastatic melanoma
Cancer kills over 8 million people every year. What makes it so deadly is its ability to spread from the organ where it originates to the rest of the body, a process known as metastasis. Even though
Radiation therapy for nerve pain when cancer spreads to bones
One of the hallmarks of cancer is its ability to spread from the primary site of origin to other places in the body. Such secondary sites are called “metastases”. One of the commonest sites for cancer secondaries
