Tag Archives: model
Cs adsorption by Mn‒Fe-based Prussian blue analogs formed in agarose gel
The Fukushima nuclear accident triggered a massive release of radioactive cesium (Cs) isotopes into the environment and generated a large amount of contaminated water. Because Cs isotopes pose serious threats to the environment (particularly the aquatic environment),
Biophysical modulation of lipid model membranes by cobalt and nickel
Cobalt (Co) and Nickel (Ni) are important industrial metals used in the manufacture of a variety of everyday products. Additionally, Co is an essential trace element for humans, involved in the structure and function of vitamin B12.
Turkey model for flexor tendon research – can it replace the canine model?
Battlefield hand injuries accounted for 20 to 30% of combat wounds during Operation Iraqi Freedom, in which, soft tissue injuries compromised the majority in hand trauma. Flexor tendon injuries are among the most severe of hand injuries,
Acute ischemic stroke: An urgent call for help and funding!
In humans, acute ischemic stroke is the primarily result of a blood-clot that moves toward the brain and blocks one or more important blood vessels that supply blood, oxygen, and nutrients to brain tissue (Fig. 1), causing
A murine type 2 diabetes mellitus model mimicking metabolic characteristics similar to humans
Type 2 diabetes mellitus (T2DM) which accounts for more than 95% of all diabetes cases is a heterogeneous, multifactorial disorder typified by hyperglycemia with gradual decline in insulin action (insulin resistance), followed by the inability of beta
Simple mathematical formulas for tracking the number of antibiotic resistance cases globally
In order to continue to live, microbes and germs have found ways to prevent drugs from killing them in the process of curing patients—when the patients ingest the drugs for treatment. Microbes destroying drugs within patients and
The blood is Newtonian in LDL deposition through artery walls
The formation of an atherosclerotic plaque causes various cardiovascular diseases, such as a heart attack. In this process, the Low-Density Lipoprotein (LDL) has a main role, since it infiltrates in the artery wall and promotes the process,
Multiplex methods provide effective integration of multi-omic data in genome-scale models
Structures called networks are often used as a way of simplifying complex problems. For instance, you’ve probably heard of social networks, where we simplify the complexity of human interactions by categorizing each pair of people as either
In vivo imaging of immunotherapeutic glioma model
Glioblastoma remains one of the deadliest diseases faced by patients, with a median survival of less than 15 months. Therapeutic advancements in the field rely heavily on animal models, and the use of human brain tumor cells
Biophysical characterization of monofilm model systems composed of selected tear film phospholipids
While our eyes are open they are constantly exposed to bacterial infections, injury, and dehydration. To provide the necessary protection against these hazards the outer surface of our eyes is covered by a thin layer known as
The tripartite cognitive model of panic disorder
Panic attacks (PA) are very common phenomena and represent a nonspecific risk factor for psychopathology. Approximately 5% of individuals who experience unexpected PA develop panic disorder (PD), a chronic clinical condition of recurrent unexpected PA and persistent
Fighting chronic rejection of transplanted organs
In many diseases the only available cure is organ transplantation. However, if the transplanted organ does not derive from an identical twin (which is genetically identical to the recipient) it becomes rejected by the immune system of
From complex questionnaire and interviewing data to intelligent Bayesian Network models
Medical data is very often badly structured, incomplete and inconsistent. This limits our ability to generate useful models for prediction and decision support if we rely purely on machine learning techniques. That means we need to exploit expert
The key key to open the door of iPSCs clinical therapy for patients
The discovery of iPSCs is probably one of the most astonishing accomplishments in the beginning of 21st century. This is by 4 early protein factors, the differentiated cells–such as fibroblasts, T and B cells—can return to pluripotent
Reconstruction of chromosomal structures
Under a certain approximation, the following simplified format can be adopted. DNA is considered as a very long sequence in the {A,C,T,G} alphabet. Certain regions of the sequence with specific positions have a particular role and are
Comparison of the effect of exercise on late-phase LTP of the dentate gyrus and CA1 of Alzheimer’s disease model
There has been a recent upsurge of scientific reports about the benefits of regular physical exercise for general health and particularly for mental health. Healthy diet and physical activity have emerged as promising low-cost measures for protection
Curcumin, from Indian spice to a molecular model in drug discovery?
Nature has provided a large variety of molecules, with different degrees of complexity and therapeutic applications. Curcumin (Fig. 1) is an example of such molecules. Curcumin is a natural compound isolated from the rhizomes of the plant
Does acute kidney injury affect other organs?
Acute Kidney Injury (AKI) is a common and serious condition with no specific treatment. AKI has been estimated to cost the NHS in the UK alone between £451-626 million per year. Recovery from a single episode of
Importance of updating prognostic predictions: an example from breast cancer
Today prognostic prediction models are an integral part of clinical practice in many fields. They are typically used to access the risk of an event in the future after a well-defined starting point, for instance the risk
Placental transfer of the HIV drug dolutegravir in a human ex vivo perfusion model
The fetus of an HIV-positive woman has a 25% chance of becoming infected during pregnancy. HIV medicines have shown to be highly effective in preventing fetal infection with HIV. A part of the efficacy but also the
