Tag Archives: model

A murine type 2 diabetes mellitus model mimicking metabolic characteristics similar to humans

Type 2 diabetes mellitus (T2DM) which accounts for more than 95% of all diabetes cases is a heterogeneous, multifactorial disorder typified by hyperglycemia with gradual decline in insulin action (insulin resistance), followed by the inability of beta

Simple mathematical formulas for tracking the number of antibiotic resistance cases globally

In order to continue to live, microbes and germs have found ways to prevent drugs from killing them in the process of curing patients—when the patients ingest the drugs for treatment. Microbes destroying drugs within patients and

The blood is Newtonian in LDL deposition through artery walls

The formation of an atherosclerotic plaque causes various cardiovascular diseases, such as a heart attack. In this process, the Low-Density Lipoprotein (LDL) has a main role, since it infiltrates in the artery wall and promotes the process,

Multiplex methods provide effective integration of multi-omic data in genome-scale models

Structures called networks are often used as a way of simplifying complex problems. For instance, you’ve probably heard of social networks, where we simplify the complexity of human interactions by categorizing each pair of people as either

In vivo imaging of immunotherapeutic glioma model

Glioblastoma remains one of the deadliest diseases faced by patients, with a median survival of less than 15 months. Therapeutic advancements in the field rely heavily on animal models, and the use of human brain tumor cells

Biophysical characterization of monofilm model systems composed of selected tear film phospholipids

While our eyes are open they are constantly exposed to bacterial infections, injury, and dehydration. To provide the necessary protection against these hazards the outer surface of our eyes is covered by a thin layer known as

The tripartite cognitive model of panic disorder

Panic attacks (PA) are very common phenomena and represent a nonspecific risk factor for psychopathology. Approximately 5% of individuals who experience unexpected PA develop panic disorder (PD), a chronic clinical condition of recurrent unexpected PA and persistent

Fighting chronic rejection of transplanted organs

In many diseases the only available cure is organ transplantation. However, if the transplanted organ does not derive from an identical twin (which is genetically identical to the recipient) it becomes rejected by the immune system of

From complex questionnaire and interviewing data to intelligent Bayesian Network models

Medical data is very often badly structured, incomplete and inconsistent. This limits our ability to generate useful models for prediction and decision support if we rely purely on machine learning techniques. That means we need to exploit expert

The key key to open the door of iPSCs clinical therapy for patients

The discovery of iPSCs is probably one of the most astonishing accomplishments in the beginning of 21st century. This is by 4 early protein factors, the differentiated cells–such as fibroblasts, T and B cells—can return to pluripotent

Reconstruction of chromosomal structures

Under a certain approximation, the following simplified format can be adopted. DNA is considered as a very long sequence in the {A,C,T,G} alphabet. Certain regions of the sequence with specific positions have a particular role and are

Comparison of the effect of exercise on late-phase LTP of the dentate gyrus and CA1 of Alzheimer’s disease model

There has been a recent upsurge of scientific reports about the benefits of regular physical exercise for general health and particularly for mental health.  Healthy diet and physical activity have emerged as promising low-cost measures for protection

Curcumin, from Indian spice to a molecular model in drug discovery?

Nature has provided a large variety of molecules, with different degrees of complexity and therapeutic applications. Curcumin (Fig. 1) is an example of such molecules. Curcumin is a natural compound isolated from the rhizomes of the plant

Does acute kidney injury affect other organs?

Acute Kidney Injury (AKI) is a common and serious condition with no specific treatment. AKI has been estimated to cost the NHS in the UK alone between £451-626 million per year. Recovery from a single episode of

Importance of updating prognostic predictions: an example from breast cancer

Today prognostic prediction models are an integral part of clinical practice in many fields. They are typically used to access the risk of an event in the future after a well-defined starting point, for instance the risk

Placental transfer of the HIV drug dolutegravir in a human ex vivo perfusion model

The fetus of an HIV-positive woman has a 25% chance of becoming infected during pregnancy. HIV medicines have shown to be highly effective in preventing fetal infection with HIV. A part of the efficacy but also the