Tag Archives: mTOR
Metformin improves pancreatic cancer and lymphoma outcomes in DM2 patients
Type 2 diabetics are at increased risk of cancer in part because of increased insulin in the blood from insulin resistance. Insulin and its related growth factor IGF-1 can stimulate cell growth through the Ras-Raf-MEK-ERK or the
Expression of mTOR-signalling pathway proteins in skin squamous-cell carcinomas before and after conversion to mTOR-inhibitors
Inhibitors of the Mammalian Target of Rapamycin (mTORis) are drugs exerting both immunosuppressive and antitumor effects, and are thereby used in organ-transplant recipients (OTR) in order to both prevent allograft rejection and to reduce the risk of
How exercise can improve your mental health – it’s a no brainer!
A plethora of studies are emerging which show the positive effects that exercise can have on mental health and emotional state. The physical effects of exercise include reduction of blood pressure, greater cardiovascular fitness, weight loss and
A new drug to improve drug-eluting stents in coronary artery disease
Patients with symptomatic coronary artery disease often receive stent treatment in obstructed coronary arteries of the heart. Even though current generation drug-eluting stents perform very well in the short-term, concerns still exist about their long-term efficacy due
A new chance for rapamycin
Rapamycin is a bacterially-produced drug first discovered in the soil of Easter Island, and currently used as an immunosuppressant for organ transplantation and the treatment of certain types of cancer. Rapamycin has received popular attention following the
How the immune system is regulated by small RNAs called microRNAs to prevent self-attacks leading to autoimmunity
The ability to properly engage the different arms of the immune response is essential for protection from pathogens but also for preventing autoimmune reactions against normal tissue. Central to autoimmune prevention are a class of white blood
Putting mammalian target of rapamycin on track
Mammalian target of rapamycin (mTOR) is the target protein of rapamycin, a bacterial metabolite in Streptomyces hygroscopicus primarily found in the soil sample from Easter Island in South America thirty years ago. Since mTOR was discovered in
