Tag Archives: neurodegeneration

Lipids keeps shrinking with aging and neurodegeneration

AoS. Lipids keeps shrinking with aging and neurodegeneration.

I remember when my Biology teacher at the secondary school introduced us for the first time to the biochemical components of the living cells. I was immediately fascinated by the elegant code making of the nucleic acids,

Mitophagy in health and disease

Mitophagy in health and disease. AoS

Mitochondria are cellular organelles specialized for energy production, and critically influence several features of cellular metabolism and physiology. Maintenance of a healthy mitochondrial pool is a prerequisite for cellular and tissue homeostasis. Compromised mitochondrial function results in

Neonatal programming of pesticide-induced neurodegeneration

Permethrin (PERM) is a pesticide of the pyrethroid class widely used in agriculture to protect crops and in general its main application is as insect repellent. It is also a component of many creams against skin diseases

Motor nerve terminals with fast downregulation of Syt1 are more vulnerable in Spinal Muscular Atrophy

Spinal Muscular Atrophy (SMA) is the most frequent genetic cause of infant mortality. It is caused by mutations or loss of the SMN1 gene, which codifies for the Survival of Motor Neuron (SMN) protein. SMN has an

Is Metformin a new risk factor for Parkinson`s disease?

Parkinson’s disease is a neurodegenerative disorder that takes place when the neurons of the substantia nigra, a brain structure involved in the movement control, die. This leads to several symptoms including motor and cognitive dysfunctions, progressive loss

Retromer in polarized protein transport

In living organisms, all cells contain different compartments called organelles. Each organelle, surrounded by lipid membranes, includes a characteristic set of resident molecules. Maintenance of such precise set of components in each organelle is critical for proper

Neurodegeneration-associated RNA-binding protein, FUS, regulates mRNA length

RNA processing, including alternative regulations of transcription initiation, splicing, and 3’ end formation of pre – mRNA, is a highly specialized mechanism that enables to generate multiple isoforms from a single gene. This mechanism expands transcriptome and