Tag Archives: neurodegeneration
Lipids keeps shrinking with aging and neurodegeneration
I remember when my Biology teacher at the secondary school introduced us for the first time to the biochemical components of the living cells. I was immediately fascinated by the elegant code making of the nucleic acids,
Extracellular cytochrome c: a novel damage-associated molecular pattern (DAMP) of the brain
Cytochrome c (CytC) is a protein that is normally located inside mitochondria where it participates in the energy-generating processes of cells. Since mitochondria are essential for life, these CytC-containing organelles are found in most animal cells. The
Mitophagy in health and disease
Mitochondria are cellular organelles specialized for energy production, and critically influence several features of cellular metabolism and physiology. Maintenance of a healthy mitochondrial pool is a prerequisite for cellular and tissue homeostasis. Compromised mitochondrial function results in
Neonatal programming of pesticide-induced neurodegeneration
Permethrin (PERM) is a pesticide of the pyrethroid class widely used in agriculture to protect crops and in general its main application is as insect repellent. It is also a component of many creams against skin diseases
Motor nerve terminals with fast downregulation of Syt1 are more vulnerable in Spinal Muscular Atrophy
Spinal Muscular Atrophy (SMA) is the most frequent genetic cause of infant mortality. It is caused by mutations or loss of the SMN1 gene, which codifies for the Survival of Motor Neuron (SMN) protein. SMN has an
Is Metformin a new risk factor for Parkinson`s disease?
Parkinson’s disease is a neurodegenerative disorder that takes place when the neurons of the substantia nigra, a brain structure involved in the movement control, die. This leads to several symptoms including motor and cognitive dysfunctions, progressive loss
Retromer in polarized protein transport
In living organisms, all cells contain different compartments called organelles. Each organelle, surrounded by lipid membranes, includes a characteristic set of resident molecules. Maintenance of such precise set of components in each organelle is critical for proper
Neurodegeneration-associated RNA-binding protein, FUS, regulates mRNA length
RNA processing, including alternative regulations of transcription initiation, splicing, and 3’ end formation of pre – mRNA, is a highly specialized mechanism that enables to generate multiple isoforms from a single gene. This mechanism expands transcriptome and
