Tag Archives: neuroprotection
Disengaging ATF6 from DREAM for neuroprotection
To study early changes in neuronal function during the pre-symptomatic phase of a given neurodegenerative disease is very important. It could deliver early diagnostic markers, offer prognostic clues about disease progression and uncover novel therapeutic targets for
Novel targets for neuroprotection in neonatal brain injury
Developing brain is highly susceptible to injury. Together, prematurity and hypoxic ischemic encephalopathy (HIE) account for 50% of global mortality and significant neurodevelopmental impairment in survivors. HIE is a clinically defined syndrome of disturbed neurologic function due
Acute ischemic stroke: An urgent call for help and funding!
In humans, acute ischemic stroke is the primarily result of a blood-clot that moves toward the brain and blocks one or more important blood vessels that supply blood, oxygen, and nutrients to brain tissue (Fig. 1), causing
Treatment for spinal cord injury
Approximately 20,000 traumatic spinal cord injuries (SCIs) occur each year in the United States. These injuries are often associated with paralysis and other permanent disabilities. SCI is now recognized to occur in two phases, described as primary
A versatile in vitro bioassay for the screening of neurotrophic factor gene therapy systems to combat blindness
Glaucoma is the world’s second leading cause of blindness after cataracts, affecting about 80 million people worldwide annually. The disease is characterized by neurodegeneration involving a progressive visual field loss from the periphery towards the center, and
Glucose – a bitter sweet for the brain
During ischemic stroke, insufficient supply of oxygen and glucose leads to severe damage of cerebral tissue. Since the most important energy substrate for the brain is glucose, high blood sugar levels could be a strategy to enhance
Eye opener: the gate for immune cells entering the injured eye
Disease or injury to the retina or optic nerve is one of the main causes of blindness worldwide. As such, major research efforts have been invested in finding ways to protect the neuronal cells of the retina
The power of laser light to repair brain from stroke injury
Transcranial near-infrared laser therapy (TLT) also known as NILT is a powerful non-invasive method to promote neuroprotection and repair of the damaged brain. How does it work? For many years, researchers have hypothesized that laser light at
Revisiting NMDA receptor inhibitors that work differently hoping to treat brain injury and stroke
Over-activation of NMDA receptors, a subtype of glutamate receptors, has long been suspected to contribute to the development of the penumbral zone of damage that develops hours after a traumatic brain injury or stroke occurs. This area
