Tag Archives: neurotoxicity
Ketamine, not TPS potentiates glutamate-induced Ca neurotoxicity
There is growing concern about anaesthesia effects on the developing brain because commonly used anaesthetics can cause neurodegeneration and long-term neurocognitive deficits. In the developing brain, GABA-R agonists and NMDA-R antagonists cause neurotoxicity and apoptosis. Comparing their
Are iron oxide nanoparticles neurotoxic?
Among the different types of nanomaterials, iron oxide nanoparticles (ION) awaken a particular interest due to their unique properties, including superparamagnetism and high biocompatibility. These features make them very suitable for a broad variety of uses, mostly
New psychoactive substances: metabolites of synthetic cathinones induce cytotoxicity in human neuronal cells
Recently, a large number of novel psychoactive substances (NPSs) have appeared on the European market. Their growing diffusion has become matter of worldwide concern and alarm for public health authorities, legislators, and clinical health specialists. They are
Computer simulations predict the cause of a drug’s fatal neurotoxicity in a failed clinical trial
A new drug called BIA 10-2474, in development for pain management, caused severe side effects in a clinical trial in France in 2016. In the safety phase of the clinical trial, one healthy participant died from unexpected
Reversibility of Aβ oligomer neurotoxicity: Insights into the treatment of Alzheimer’s disease
Alzheimer’s disease (AD), the most common neurodegenerative dementia disorder, causes memory impairment and other cognitive deficits. AD is neuropathologically characterized by senile plaques and neurofibrillary tangles, which are composed of amyloid β-protein (Aβ) and phosphorylated tau proteins,
Can metal-exposure induce innate immune reactivity in brain cells and thus contribute to neurotoxicity?
Use of metals in dentistry is quite common for braces, crowns, fillings, implants. Problems sometimes occur, such as allergy, locally inflamed mucosae, or vague symptoms throughout the entire body. However, alternatives such as methacrylates will never completely
