Tag Archives: oligomer
Reversibility of Aβ oligomer neurotoxicity: Insights into the treatment of Alzheimer’s disease
Alzheimer’s disease (AD), the most common neurodegenerative dementia disorder, causes memory impairment and other cognitive deficits. AD is neuropathologically characterized by senile plaques and neurofibrillary tangles, which are composed of amyloid β-protein (Aβ) and phosphorylated tau proteins,
New morphology of amyloid fibrils
It has been shown earlier that one of the proteins from the Saccharomyces cerevisiae cell wall (glucantransferase Bgl2) forms amyloid structures after isolation from cell wall under acid pH conditions. It is known that the acid treatment
Unusual structure of aggregates formed by the fragment of Аβ(16-25) peptide
By the moment, a large number of proteins and peptides, polymerization of which in fibril formations leads to emergence of different diseases (amyloidosis), have been identified. But it is not always that fibril formations are toxic for
Determination of the size of folding nuclei of fibrils formed from Aβ(1-40) peptide
One of the most important models for studying amyloid fibril formation is the Aβ peptide, aggregates of which form plaques in the course of Alzheimer`s disease. Formation of Aβ aggregates goes through the nucleation mechanism with exponential
Small or big, brain cells don’t like protein gunk that lead to diseases like Alzheimer’s, Parkinson’s and Huntington’s
An interdisiciplinary study by scientists at Trinity College Dublin (TCD, Ireland) have answered a hotly debated question in the neurodegenerative diseases research area: “Which protein aggregate form is the primary pathogenic agent in neurodegenerative diseases – (i) the prefibrillar oligomeric
