Tag Archives: orexin
Orexin-A regulates dopamine D2 receptor in the mesolimbic circuit
Orexin-A (orx-A) is a neuropeptide expressed exclusively in hypothalamic neurons. Orx-A acts through the activation of type-1 (Orx1R) and -2 (Orx2R) receptors present in the mesolimbic circuit and in other brain areas. These neuropeptides have been implicated
Suvorexant, a dual orexin receptor antagonist, may work as a glucose regulatory switch
Glucose is the predominant metabolic fuel for the brain. Thus, the mechanism of glucose regulation is crucial to survival. Insulin is the main glucose regulatory hormone among redundant glucose regulatory factors. However, we found that suvorexant, a
Why narcoleptic mice exhibit faster recovery from sickness behavior?
Hypocretin/ataxin-3 mice (which are postnatally depleted of hypothalamic hypocretin neurons) were administered LPS. As a result, hypocretin/ataxin-3 mice were increased in sleep compared with wild-type littermates and showed faster recovery from sickness behaviour. We examined changes in