Tag Archives: osteoarthritis

Mesenchymal stem cells for treating knee osteoarthritis

AoS.Mesenchymal stem cells for treating knee osteoarthritis

Cartilage in the knee does not heal very well nor very quickly, so continued use of the leg when walking for example can result in further damage, bony projections (osteophytes), stiffening and swelling of the joint (Fig.

Osteoarthritis alleviation by rewiring cellular energy metabolism

Osteoarthritis (OA) is a chronic disorder associated with degeneration of the joint, including articular cartilage, subchondral bone, synovial tissue, tendons, periarticular muscles that involves low-grade systemic inflammation. Recent studies have demonstrated the involvement of chondrocyte differentiation (hypertrophy)

Large animal models for osteochondral regeneration

Comparison of common currently used large animal models

Due to the lacking of a blood supply and the low cellular density of articular cartilage, this hard tissue has a limited healing capacity. Therefore, focal traumatic events causing cartilage defects rarely resolve spontaneously or are usually

Osteoarthritis of the wrist: Improved understanding of wrist movements leads to novel advancement in wrist replacement surgery

Like every other joint in the body covered by cartilage, the wrist can develop osteoarthritis. Many treatments have been attempted including cutting sensory nerves to relieve pain, stiffen the wrist, partially removing some of the joint and,

Biodegradable microparticles used to prolong drug release to inhibit inflammation in osteoarthritis

Articular cartilage is located on the surfaces of the bones in the synovial joint. It protects the underlying bones from damage and shock, but also functions as a lubricant for frictionless movements of the human body. Damage

Glucosamine reduces the need for pain medications in osteoarthritis, but the correct formulation is essential

For osteoarthritis, drugs that can delay disease progression have the potential to reduce the need for additional pain medications. But be careful which drug you chose: this effect is only shown with the prescription patented crystalline glucosamine

The effect of dehydroepiandrosterone in different stages of osteoarthritis

Osteoarthritis (OA) is likely to become an increasing burden in the coming decades. Current medications for OA, including nonsteroidal anti-inflammatory drugs (NSAIDS), steroids or viscosupplementation provide only symptomatic improvements. The major disadvantage of all current treatments is