Tag Archives: Osteoporosis

Unlocking new treatments for bone diseases: using PEPITEM to strengthen bones and prevent loss

Despite appearances, bones are a constantly changing organ in the body. Cells that produce new bone (named osteoblasts) and cells that break down bone (named osteoclasts) work in harmony to ensure that old bone is continuously replaced,

Large animal models for osteoporosis research: The small ruminants (sheep and goat)

Role of oestrogen in bone remodeling

In the healthy skeleton, constant bone remodeling occurs in which mature bone tissue is removed, in a process called resorption, and new tissue is formed in order to maintain bone strength and mineral homeostasis in continuum with

What is a SERM and how does it work?

Estrogen receptors (ERα and ERβ) are nuclear receptors that function as ligand-dependent transcription factors. They play a vital role in many physiological functions such as the development and differentiation of the reproductive tract and mammary gland. They

Noni leaf, black tea and Black cohosh encouraged bone growth in post-menopausal mammals

High intake of black tea and certain types of flavonoids were associated with lower risk of fracture-related hospitalizations in elderly women at high risk of fracture. Black tea consumption increased serum estradiol and prevented bone loss in

The Fracture Liaison Service. A standardized order set towards efficient management of fragility fractures with minor expenses

Over more than a decade, the secondary fracture prevention strategy has been the heart of osteoporosis-related fracture management studies. Management programs have oscillated between low and high levels of intensity of intervention(s); sensitization through letters or pamphlets,

The link between osteoporosis and periodontal disease

Osteoporosis and periodontal disease are both characterized by bone resorption. After menopause, bone loss rate is dramatically accentuated, which seems to potentially accelerate and/or aggravate periodontal tissue breakdown. The dental biofilm induces the immune system to produce

Osteoporosis and erythroid cells: is there a connection?

The skeleton is an extraordinary structure paramount not only for our movement but for multiple other functions as well. Bones are dynamic organs that continuously remodel through life in a process where mature bone is removed by

Unusual fractures in osteoporosis

Osteoporosis is common in our aging population and is a major reason for loss of independence and deterioration of quality of life. Medications are often required to treat osteoporosis and such treatments, particularly drugs of the bisphosphonate

Theophylline, a drug to treat asthma increases risk of fracture and causes vitamin D deficiency

Incidence of chronic obstructive pulmonary diseases (COPD) of which asthma is the commonest manifestation is growing by leaps and bounds in two most populous countries, India and China due to rapid growth of industrialization and associated rise

Osteoporosis in childhood

It is well known that bones tend to become brittle with ageing. Less well-known is that children also suffer from fractures resulting from little or no force to provoke the injury. The cause in some children is

Is a tissue-engineering approach effective for the treatment of osteoporotic bone defects?

Osteoporosis (OP) is a disease that affects the formation, maintenance, and density of bone. OP is also associated with an increased risk of bone fracture. For those people/patients facing a traumatic injury or tumor removal in the

Clay nanotubes loaded with Sr(II) could help in designing composite scaffolds for bone regeneration

The treatment of age-related diseases is a high-priority issue in modern western societies, mainly because of the progressive ageing of the population and the increase in life expectancy. Osteoporosis, literally “porous bone”, is a condition in which

Genetics and dietary stress explain low calcium absorption

It is well understood that osteoporosis is influenced by a variety of environmental factors such as age, nutrition, and race. Calcium absorption is one of these important factors and low levels of calcium absorption have been associated

Hip arthroplasty when reconstructed are significantly less effective for osteoporotic than for healthy bone

The number of primary hip replacements has increased substantially in the United States and each year, as many as 200,000 total hip replacements ( THR ) are performed annually. Total hip arthroplasty is generally performed with cementless