Tag Archives: oxidative stress
Linking copper, tyrosines and protein aggregation in Alzheimer’s disease
The prevalence of Alzheimer’s disease (AD), the most common cause of dementia nowadays, is expected to increase within the coming years, representing a serious threat for society and the healthcare system. For this reason, a lot of
Other components of less common oilseeds are much more beneficial for health than their unsaturated fats
Polyunsaturated fatty acids (PUFA) are thought to be some of the most important nutrients and health promoting constituents, the presence of which is usually insufficient in a daily diet, which in turn is often connected with their
When will my mouse die?
The maintenance of health is ensured by the function of the three homeostatic systems of the body: the nervous, endocrine and immune systems, and by the net that allows crosstalk between them: the neuroimmunoendocrine communication. With aging,
The suitability of scopolamine as an Alzheimer’s model
Alzheimer’s disease is the most common cause of dementia. About 50 million people worldwide have Alzheimer’s disease or a related form of dementia. Alzheimer’s disease is a terminal illness affecting mostly the elderly above the age of
When toxicity goes circular: Isoprostanes as markers and effectors of oxidative stress
In normal conditions, there is a dynamic equilibrium between oxidants and antioxidants in the human body; however, when there is an unbalance in this redox state, oxidative stress occurs. In an unbalanced state, the peroxidation of polyunsaturated
How alcohol consumption might contribute to viral liver infections?
The coexistence between excessive alcohol consumption and hepatitis C virus (HCV) infection is causative of a high death ratio annually. It is well-known that phosphoinositides (PI) not only regulate a number of physiological processes but also they
Analysis of serum biomarkers and their correlation with pain and quality of life in the rare disease alkaptonuria
Alkaptonuria (AKU) is an ultra-rare disease causing an early onset, chronically debilitating spondylo-arthropathy due to deposition of an ochronotic pigment in joints and spine, which causes severe pain and greatly reduces patients’ quality of life. Despite an
Reactive oxygen species, Devil or Angel?
Reactive oxygen species (ROS) have an amazing oxidative potential with oxidative stress and could abolish the integrity of living cells. Vigorous production of ROS can damage mitochondria and DNA, which would persistently destroy the cells and might
Butyrate enhances mitochondria respiration when challenged with oxidative stress
Butyrate is a ubiquitous short-chain fatty acid (4 carbons in length) that has been shown to have many health benefits. Butyrate is principally produced by the trillions of microbial cells that live in our intestine commonly known
The role of oxidative stress in Type 2 diabetes
Type 2 diabetes is a major health concern that affects people no matter their gender, race, or socio-economic background is. In type 2 diabetes, a person’s body stops responding efficiently to insulin after a meal. This desensitization
Absence of bilirubin increases oxidative stress in vivo
Oxidative stress, defined as an imbalance between oxidants and antioxidants in favor of the former, is a hallmark of many diseases, including cardiovascular disease (CVD) and related metabolic syndrome. Modifying uncontrolled oxidative stress may attenuate the development
Why iron and copper may be harmful to the aging brain
Similar to other organs, brain function declines with age. Furthermore, age is the single greatest risk factor for Alzheimer’s disease as well as other neurodegenerative diseases. Both iron and copper increase in the brain with aging and
Early sepsis does not stimulate reactive oxygen species production and does not reduce cardiac function despite an increased inflammation status
Sepsis is due to bacterial infection. If it is sustained for several days, it can trigger severe abnormalities of cardiac function which leads to death in 50% of cases. This probably occurs through activation of toll-like receptors
Oxidative stress sensitivity of cancer cells could be altered by plasma membrane status
Oxidative stress is defined as “A status that the balance between the oxidation reaction and the antioxidant reaction is lost in our body, and that the oxidation state is dominant.” Oxidative stress is generally adverse for our
The promiscuous mineralocorticoid receptor
Hormones and nerves are the key communication systems in the human body. Nerves are like a fixed-line telephone network, capable of very fast messaging: think of the pianist’s fingers playing the Minute Waltz. Hormones are like radio,
Fish responses to ocean acidification comes with a cost
Ocean acidification is currently recognized as a major threat to marine ecosystems and has become one of the fastest growing research fields in marine sciences. The excessive amount of anthropogenic carbon dioxide is making our oceans warmer
Nanodiamonds are just around the corner
The expansion of nanotechnology cause increased penetration of nanoparticles into the environment and their exposure of animals becomes inevitable. Consequently studies on their effects and potential toxicity is now gaining attention. Nanodiamonds (ND) are allotropes of carbon
Pathological role of oxidative stress and related with schizophrenia in T. gondii infection
Toxoplasma gondii (T. gondii) is an obligate intracellular parasite that infects all warm-blooded animals, including humans. Oxidative stress (OS) occurs when there is an imbalance between pro-oxidant and antioxidant factors and is induced by reactive nitrogen species
Neuroprotection for stroke: Progesterone treatment reduces brain mitochondrial dysfunction
Every year, six million people die from stroke and five million are left disabled. 80% of strokes are ischemic and happen when blood flow is blocked in a part of the brain, due to occlusion of brain
Blockade of estrogen receptor alpha mitigates alcohol-evoked myocardial dysfunction in female rats
Recent evidence challenges the longstanding view that light-to-moderate alcohol drinking might confer cardioprotection, and the latter is mostly based on population studies in men or in male experimental animals. However, while the reduction in blood pressure caused
