Tag Archives: pain
Muscle pain treated with injected normal saline solution
Pain comes in all shapes and sizes. Ranging from acute to chronic, from nociceptive and myofascial to neuropathic, pain is a part of life. Myofascial or muscle pain, is among the most common. With a lifetime prevalence
L-Mesitran Medical Grade Honey works better for treating cold sores than conventional treatments
In a recent clinical study, it was shown that L-Mesitran improves the healing time of cold sores in relation to conventional treatments. In addition, pain and itching were decreased. Cold sores are blisters around the nose and
New Human-Based Study Into the Pain Reduction Effects of CBD
The results of a new study performed at Syracuse University has been published in the Experimental and Clinical Psychopharmacology journal. This new research looked into the ability of CBD to reduce pain in human test subjects, as
Duloxetine: a promising perioperative analgesic
Duloxetine is a dual serotonin-norepinephrine receptor inhibitor that is commonly used as an antidepressant. This drug has traditionally been used for chronic pain conditions, such as fibromyalgia and back pain, showing positive recovery outcomes. Given these analgesic
In vivo 2-color multiphoton imaging of genetic reporter fibroblasts in the skin
Fibroblasts are cells that synthesize collagen and support the maintenance of connective tissue in the skin, tendons, and joints. They maintain a critical role in the immune system’s response to tissue injury by promoting wound healing at
Health care utilization for chronic musculoskeletal pain risk: Lessons from the CRASH study
Each year, over four million people go to U.S. Emergency Departments (ED) after a motor vehicle crash (MVC). Although the vast majority of patients are sent home without any serious injuries, many will experience aches and pains
Pain cognition in migraine
The evolving concept of pain has led to the reformulation of its biological meaning by placing it in a much broader frame. Currently, we look at pain as a multidimensional sensation, aimed not only to the localization
Astrocytes modulate spinal pain processing by way of cannabinoid induced endocannabinoid release
Astrocytes were long thought to play only a supporting role in the central nervous system. However, the discovery that Ca2+ transients in astrocytes are coupled to the enhancement or depression of neuronal activity has led to the
Analysis of serum biomarkers and their correlation with pain and quality of life in the rare disease alkaptonuria
Alkaptonuria (AKU) is an ultra-rare disease causing an early onset, chronically debilitating spondylo-arthropathy due to deposition of an ochronotic pigment in joints and spine, which causes severe pain and greatly reduces patients’ quality of life. Despite an
Pursuit of a genuine effect of acupuncture: development of placebo acupuncture needles
Acupuncture has been used to treat a wide range of health conditions. The efficacy of acupuncture has not conclusively been established because only randomized control trials using single-blind needles have been reported. Single blinding is problematic because
Prescription opioid use underestimated in the United States
The opioid epidemic continues to have many negative effects in the US. The US lifespan has been decreasing and opioid overdoses are believed to be responsible. Other consequences of opioid misuse include the increases in emergency room
Nerve conduction inhibition by various antidepressants used to alleviate chronic pain
Information of nociceptive stimuli given to the periphery is transmitted through the dorsal root to the superficial spinal dorsal horn, and then flows to the primary-sensory area of the cerebrum through the brainstem and thalamus, causing pain
Amniotic membranes can ease the eye pain
The cornea is one of the most innervated tissues in the body. When the corneal nerves undergo damage from various causes (such as refractory dry eye, corneal burns and infections, refractive surgery, among others), abnormal nerve regeneration
How can we understand persistent pain?
Acute pain evoked by tissue injury makes biologic sense and can be explained mechanistically in great detail. It is much more difficult to understand why pain so often persists after healing of an injury, or even arises
Back pain research: Skirting around the edges?
Low back pain is the leading cause of disability worldwide. The fact that it is seldom possible to identify a specific nociceptive cause is thought to be a major barrier to its successful management. At the same
Pain sensitivity and pain scoring in patients with severe obesity
There are indications that pain perception is altered in patients with obesity, which complicates postoperative pain treatment. An essential part for adequate pain treatment is the capacity of the patient to grade pain. Methods Forty-one patients with
A selective AC1 inhibitor relieves pain
Adenylyl cyclases (AC) are proteins expressed throughout the human body. ACs have a central role in cellular and neuronal function. A number of different proteins and ions can interact with ACs and modulate their activity. ACs have
Serotonin and noradrenaline reuptake inhibitor (SNRI) for chronic musculoskeletal pain may be a red herring?
Dysfunction in the central serotonin and noradrenaline systems cause not only depression but also increased pain sensitivity. Many animal studies indicated that lumbar-intrathecal administration of serotonin and noradrenaline reuptake inhibitor (SNRI) could ameliorate the pain sensitivity which
Stress and pain – subgroups, mechanisms and treatment outcomes
Chronic pain affects 100 million US adults and with costs exceeding $500 billion per year. Fibromyalgia (FM) is a prevalent chronic pain disorder characterized by widespread pain, fatigue, anxiety and depression, and problems with memory and concentration.
An oblique approach to the lumbar spine: what we know so far
As people get older, lower back and leg pain is a common and often debilitating problem, preventing simple tasks including walking. Unfortunately it is unavoidable because of simple wear-and-tear of the discs and joints that make up
