Tag Archives: pain

Duloxetine: a promising perioperative analgesic

Atlas of Science. Duloxetine: A Promising Perioperative Analgesic.

Duloxetine is a dual serotonin-norepinephrine receptor inhibitor that is commonly used as an antidepressant. This drug has traditionally been used for chronic pain conditions, such as fibromyalgia and back pain, showing positive recovery outcomes. Given these analgesic

In vivo 2-color multiphoton imaging of genetic reporter fibroblasts in the skin

AoS. In vivo 2-color multiphoton imaging of genetic reporter fibroblasts in the skin.

Fibroblasts are cells that synthesize collagen and support the maintenance of connective tissue in the skin, tendons, and joints. They maintain a critical role in the immune system’s response to tissue injury by promoting wound healing at

Health care utilization for chronic musculoskeletal pain risk: Lessons from the CRASH study

Each year, over four million people go to U.S. Emergency Departments (ED) after a motor vehicle crash (MVC). Although the vast majority of patients are sent home without any serious injuries, many will experience aches and pains

Pain cognition in migraine

Pain cognition in migraine. AoS

The evolving concept of pain has led to the reformulation of its biological meaning by placing it in a much broader frame. Currently, we look at pain as a multidimensional sensation, aimed not only to the localization

Astrocytes modulate spinal pain processing by way of cannabinoid induced endocannabinoid release

Astrocytes modulate spinal pain. AoS

Astrocytes were long thought to play only a supporting role in the central nervous system. However, the discovery that Ca2+ transients in astrocytes are coupled to the enhancement or depression of neuronal activity has led to the

Analysis of serum biomarkers and their correlation with pain and quality of life in the rare disease alkaptonuria

Analysis of serum biomarkers and their correlation with pain

Alkaptonuria (AKU) is an ultra-rare disease causing an early onset, chronically debilitating spondylo-arthropathy due to deposition of an ochronotic pigment in joints and spine, which causes severe pain and greatly reduces patients’ quality of life. Despite an

Pursuit of a genuine effect of acupuncture: development of placebo acupuncture needles

Acupuncture needles for double blinding

Acupuncture has been used to treat a wide range of health conditions. The efficacy of acupuncture has not conclusively been established because only randomized control trials using single-blind needles have been reported. Single blinding is problematic because

Prescription opioid use underestimated in the United States

The opioid epidemic continues to have many negative effects in the US. The US lifespan has been decreasing and opioid overdoses are believed to be responsible. Other consequences of opioid misuse include the increases in emergency room

Nerve conduction inhibition by various antidepressants used to alleviate chronic pain

Information of nociceptive stimuli given to the periphery is transmitted through the dorsal root to the superficial spinal dorsal horn, and then flows to the primary-sensory area of the cerebrum through the brainstem and thalamus, causing pain

Amniotic membranes can ease the eye pain

The cornea is one of the most innervated tissues in the body. When the corneal nerves undergo damage from various causes (such as refractory dry eye, corneal burns and infections, refractive surgery, among others), abnormal nerve regeneration

How can we understand persistent pain?

Acute pain evoked by tissue injury makes biologic sense and can be explained mechanistically in great detail. It is much more difficult to understand why pain so often persists after healing of an injury, or even arises

Back pain research: Skirting around the edges?

Low back pain is the leading cause of disability worldwide. The fact that it is seldom possible to identify a specific nociceptive cause is thought to be a major barrier to its successful management. At the same

Pain sensitivity and pain scoring in patients with severe obesity

There are indications that pain perception is altered in patients with obesity, which complicates postoperative pain treatment. An essential part for adequate pain treatment is the capacity of the patient to grade pain. Methods Forty-one patients with

A selective AC1 inhibitor relieves pain

Adenylyl cyclases (AC) are proteins expressed throughout the human body. ACs have a central role in cellular and neuronal function. A number of different proteins and ions can interact with ACs and modulate their activity. ACs have

Serotonin and noradrenaline reuptake inhibitor (SNRI) for chronic musculoskeletal pain may be a red herring?

Dysfunction in the central serotonin and noradrenaline systems cause not only depression but also increased pain sensitivity. Many animal studies indicated that lumbar-intrathecal administration of serotonin and noradrenaline reuptake inhibitor (SNRI) could ameliorate the pain sensitivity which

Stress and pain – subgroups, mechanisms and treatment outcomes

Chronic pain affects 100 million US adults and with costs exceeding $500 billion per year. Fibromyalgia (FM) is a prevalent chronic pain disorder characterized by widespread pain, fatigue, anxiety and depression, and problems with memory and concentration.

An oblique approach to the lumbar spine: what we know so far

As people get older, lower back and leg pain is a common and often debilitating problem, preventing simple tasks including walking. Unfortunately it is unavoidable because of simple wear-and-tear of the discs and joints that make up

Dysfunction of cellular analgesic control in neuropathic pain

Neuropathic pain in small-fiber neuropathy was traditionally considered a consequence of injury to nociceptors and sensitization. An alternative view has also been put forward: there may be a loss of the neuronal analgesic control system, paralleling the

Inflammation alters brain function and pain processing centrally

In the last couple of years, some fascinating abilities of the immune system have emerged: The immune system is tightly interconnected with the nervous system, and can directly affect how the brain functions, and how a person

Abdominal wall schwannoma

A 62-year-old woman was admitted to our institution for the surgical evaluation of a mass in the right iliac fossa causing an enduring abdominal pain. The patient presented with the following comorbidities: visceral class I obesity (BMI