Tag Archives: pain
Each year, over four million people go to U.S. Emergency Departments (ED) after a motor vehicle crash (MVC). Although the vast majority of patients are sent home without any serious injuries, many will experience aches and pains
Astrocytes were long thought to play only a supporting role in the central nervous system. However, the discovery that Ca2+ transients in astrocytes are coupled to the enhancement or depression of neuronal activity has led to the
Analysis of serum biomarkers and their correlation with pain and quality of life in the rare disease alkaptonuria
Alkaptonuria (AKU) is an ultra-rare disease causing an early onset, chronically debilitating spondylo-arthropathy due to deposition of an ochronotic pigment in joints and spine, which causes severe pain and greatly reduces patients’ quality of life. Despite an
Acupuncture has been used to treat a wide range of health conditions. The efficacy of acupuncture has not conclusively been established because only randomized control trials using single-blind needles have been reported. Single blinding is problematic because
The opioid epidemic continues to have many negative effects in the US. The US lifespan has been decreasing and opioid overdoses are believed to be responsible. Other consequences of opioid misuse include the increases in emergency room
Information of nociceptive stimuli given to the periphery is transmitted through the dorsal root to the superficial spinal dorsal horn, and then flows to the primary-sensory area of the cerebrum through the brainstem and thalamus, causing pain
Acute pain evoked by tissue injury makes biologic sense and can be explained mechanistically in great detail. It is much more difficult to understand why pain so often persists after healing of an injury, or even arises
There are indications that pain perception is altered in patients with obesity, which complicates postoperative pain treatment. An essential part for adequate pain treatment is the capacity of the patient to grade pain. Methods Forty-one patients with
Serotonin and noradrenaline reuptake inhibitor (SNRI) for chronic musculoskeletal pain may be a red herring?
Dysfunction in the central serotonin and noradrenaline systems cause not only depression but also increased pain sensitivity. Many animal studies indicated that lumbar-intrathecal administration of serotonin and noradrenaline reuptake inhibitor (SNRI) could ameliorate the pain sensitivity which
Chronic pain affects 100 million US adults and with costs exceeding $500 billion per year. Fibromyalgia (FM) is a prevalent chronic pain disorder characterized by widespread pain, fatigue, anxiety and depression, and problems with memory and concentration.
As people get older, lower back and leg pain is a common and often debilitating problem, preventing simple tasks including walking. Unfortunately it is unavoidable because of simple wear-and-tear of the discs and joints that make up
Neuropathic pain in small-fiber neuropathy was traditionally considered a consequence of injury to nociceptors and sensitization. An alternative view has also been put forward: there may be a loss of the neuronal analgesic control system, paralleling the
In the last couple of years, some fascinating abilities of the immune system have emerged: The immune system is tightly interconnected with the nervous system, and can directly affect how the brain functions, and how a person
Our article “Stress is not pain” was a critique on a study by Elwood & Adams who exposed crabs to electric shocks and concluded that their study ‘. . .fulfils the criteria expected of a pain experience’.
In the central nervous system, signals are sent through brain pathways using neurotransmitters, the chemical messengers of our brain. The strength and duration of these messages are governed by the concentration of neurotransmitters in the synapses between