Tag Archives: pain

A selective AC1 inhibitor relieves pain

Adenylyl cyclases (AC) are proteins expressed throughout the human body. ACs have a central role in cellular and neuronal function. A number of different proteins and ions can interact with ACs and modulate their activity. ACs have

Serotonin and noradrenaline reuptake inhibitor (SNRI) for chronic musculoskeletal pain may be a red herring?

Dysfunction in the central serotonin and noradrenaline systems cause not only depression but also increased pain sensitivity. Many animal studies indicated that lumbar-intrathecal administration of serotonin and noradrenaline reuptake inhibitor (SNRI) could ameliorate the pain sensitivity which

Stress and pain – subgroups, mechanisms and treatment outcomes

Chronic pain affects 100 million US adults and with costs exceeding $500 billion per year. Fibromyalgia (FM) is a prevalent chronic pain disorder characterized by widespread pain, fatigue, anxiety and depression, and problems with memory and concentration.

An oblique approach to the lumbar spine: what we know so far

As people get older, lower back and leg pain is a common and often debilitating problem, preventing simple tasks including walking. Unfortunately it is unavoidable because of simple wear-and-tear of the discs and joints that make up

Dysfunction of cellular analgesic control in neuropathic pain

Neuropathic pain in small-fiber neuropathy was traditionally considered a consequence of injury to nociceptors and sensitization. An alternative view has also been put forward: there may be a loss of the neuronal analgesic control system, paralleling the

Inflammation alters brain function and pain processing centrally

In the last couple of years, some fascinating abilities of the immune system have emerged: The immune system is tightly interconnected with the nervous system, and can directly affect how the brain functions, and how a person

Abdominal wall schwannoma

A 62-year-old woman was admitted to our institution for the surgical evaluation of a mass in the right iliac fossa causing an enduring abdominal pain. The patient presented with the following comorbidities: visceral class I obesity (BMI

Stress must not be confused with pain

Our article “Stress is not pain” was a critique on a study by Elwood & Adams who exposed crabs to electric shocks and concluded that their study ‘. . .fulfils the criteria expected of a pain experience’. 

GlyT2 inhibitors: Getting the balance right

In the central nervous system, signals are sent through brain pathways using neurotransmitters, the chemical messengers of our brain. The strength and duration of these messages are governed by the concentration of neurotransmitters in the synapses between

Older Australians in nursing homes have limited access to complementary medicines for pain relief

In Australia and elsewhere, older people living in the community use complementary medicines (CM) to manage the symptoms of chronic illnesses, especially pain, and to supplement ‘conventional’ medical treatments for the same conditions. The bulk of CM

Benefits of aging?

Does pain increase or decrease with age, and if so, what causes the change?  A factor we considered is that sensitivity to pain could be altered by an age-related loss of neurons involved in regulation of affective/emotional

Do you have pain on the lateral side of your knee (often diagnosed as iliotibial Band Syndrome)?

Runners, bicyclists, and many other active individuals who experience pain along the lateral side of their knee joint are often diagnosed as having iliotibial band syndrome or iliotibial band friction syndrome.  This problem is attributed to a

Glucosamine reduces the need for pain medications in osteoarthritis, but the correct formulation is essential

For osteoarthritis, drugs that can delay disease progression have the potential to reduce the need for additional pain medications. But be careful which drug you chose: this effect is only shown with the prescription patented crystalline glucosamine

Extended VATS lobectomy

A lobectomy is the standard operation for removal of a lung cancer.  Traditionally, it is performed through a large incision (approximately 15 cm or 6 inches) at the side of the chest.  This incision, termed a thoracotomy,

PACAP expression induced in neuropathic pain is controlled by a splicing of REST/NRSF

Neuropathic pain (NP) is caused by the damage of the nervous system and one of the most common types of intractable pain. It is often severe, persistent, and refractory to available therapies. Although various analgesic has been

Controlling pain and symptoms at end-of-life: a better way

The World Health Organization has defined Palliative Care as: “The active total care of patients whose disease is not responsive to curative treatment. The goal… is to achieve the best quality of life for patients and their