Tag Archives: Parkinson’s disease
Can tremor, depression and progression of the Parkinson’s disease be suppressed simultaneously?
The short answer to this question is YES! Parkinson’s disease (PD) is the second most common age-related and progressive neurodegenerative disorder following Alzheimer’s disease (AD). It is associated with motor deficits such as loss of ability to
Truncation: A possible mechanism for diversity in Alpha-synuclein prion-like properties
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, which is characterized by motor disturbances such as tremor and bradykinesia resulting from severe degeneration of nigral dopaminergic neurons. The pathological hallmark of PD is the presence
Taking medicines the right way: what do people with Parkinson’s do?
Many people with Parkinson’s have problems swallowing, but they need to take many medicines to lead an independent life. It is more important for people with Parkinson’s to take their medicines on time compared with other patient
Parkinson disease: a tale of three neurotransmitters
The progressive loss of dopaminergic innervation of the basal ganglia, in particular of the dorsal striatum (putamen) is responsible for the motor signs of Parkinson disease such as bradykinesia, rigidity and loss of postural reflexes. Present therapies
GSK-3 beta: a therapeutic target for Parkinson’s disease
Neurogenesis is a process of birth of newborn neurons from neural stem cells (NSCs). It is a complex, multistep process which involves NSC proliferation, differentiation, migration, maturation and integration of newborn neurons into existing neuronal circuitry. Continuous
Dementia with Lewy bodies and Parkinson’s disease-dementia: Current perspectives
Dementia with Lewy bodies (DLB) and Parkinson’s disease-dementia (PDD) are two closely related major neurocognitive disorders with Lewy bodies of unknown etiology. Both disorders show notable overlap in their clinical presentation, pathological features, biochemistry, and genetic risk
How does Parkinson’s disease gets from your gut to your head?
Parkinson’s disease (PD) is defined as a movement disorder, characterized by a symptomatic phase of motor disturbances such as tremor and slow movements resulting from the severe degeneration of dopaminergic neurons of the substantia nigra pars compacta
Breathing problems in Parkinson’s disease: a common problem, rarely diagnosed
Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease. It is characterized by bradykinesia (slowness in movement) tremor, rigidity, and postural instability. Potential non-motor manifestations of PD include depression, anxiety, constipation, overactive bladder
Measuring motivation in Parkinson’s disease through the eyes response to money
Apathy or a lack of motivation is a disabling condition making patients feel that they “just can’t be bothered to do things”. Apathy is very common in Parkinson’s disease, affecting up to 70% of patients and causing
TRIM32 and alpha-synuclein: a novel interplay in the neuronal system
Parkinson’s disease (PD) is the second most common neurodegenerative disease mainly characterised by the progressive loss of nigrostriatal dopaminergic neurons, resulting in a series of motors symptoms and the formation of intracellular inclusions within the cells, known
‘HATs On’: A small molecule with big potential in epigenetic therapy for Parkinson’s disease
Parkinson’s disease (PD) is a common, progressive and age-related neurodegenerative disease, whose incidence is set to double by 2030 as people are living longer. At present, it is estimated that ten million people worldwide suffer with PD.
Promiscuous drugs exemplified by dopamine receptor ligands
Dopamine, often referred as “the happiness hormone”, is one of the most prominent messenger molecules in the human brain. It is a precursor of noradrenaline and adrenaline, which are neurotransmitters as well. Most people heard about dopamine
A systems-level view of cerebellar function: The interplay between cerebellum, basal ganglia, and cortex
The cerebellum is a key brain region involved in many motor functions. It contributes to coordination, precision, and accurate timing of movements as well as to motor learning and adaptation. Alongside its role in motor control, it
The environmental toxin BMAA detected in humans – Cause of neurodegenerative diseases?
Alzheimer´s disease, Parkinson´s disease and ALS ( amyotrophic lateral sclerosis ) are the most common neurodegenerative diseases in the world, and cause tremendous human suffering. Only about ten percent of the cases are hereditary, while the rest
Calcium disturbances in Parkinson’s disease
Parkinson’s disease is a common disorder of the brain that affects around 127,000 people in the UK alone. The disease is characterised by the loss of nerve cells (neurons) that control mobility. Symptoms include muscle stiffness, tremor
Targeted exercise intervention for bradykinesia in Parkinson’s disease
Exercise has been used as an intervention for many diseases; however, to maximize the benefits of any exercise intervention there we must understand that exercise is not a blunt, unidimensional tool; but rather, a malleable prescriptive instrument
The right tool for the right job – it is brain surgery after all!
Getting drugs into the brain to help treat cancer or neurological diseases like Parkinson’s or Alzheimer’s is pretty difficult. Generally speaking you can’t just take a pill or get an injection as the brain is protected by
Parkinson’s alpha-synuclein assembles in the disease prone stable dimers
The self – assembly of proteins into amyloid – type aggregates is a widespread phenomenon associated with many neurodegenerative diseases, including Parkinson’s disease (PD). According to the current model for PD, the aggregation of alpha-Synuclein (α-Syn) and
How antioxidants may have a pro-oxidant effect?
The main function of the consumption of antioxidants is to strengthen the activity of enzymatic antioxidant systems of our cells and this is intended to prevent or delay oxidative stress caused by the increase of reactive oxygen
Parkinson disease and duodenal levodopa infusion: why patients withdraw the treatment?
Parkinson disease is a chronic and progressive movement disorder associated to degeneration of neurons in the brain, particularly in a region called substantia nigra. These neurons produce dopamine, a neural transmitter that is involved in the control