Tag Archives: Parkinson’s disease

How the marmoset can help us develop new therapies for Parkinson’s disease

New advances in the treatment of Parkinson’s disease heavily depend on valid animal models of the disease that allows for the evaluation of symptoms over extended time periods. The marmoset is a primate that shares several important features

Parkinsonism Hyperpyrexia Syndrome and Deep Brain Stimulation

Deep Brain Stimulation of the subthalamic nuclei (STN-DBS) represents one of the most effective treatments in patients with Parkinson’s disease (PD) with unsatisfactory response to pharmacological therapy. STN-DBS is a neurosurgical approach based on the implantation of

How reducing cell signalling protects neurons against synapse degeneration

Dementia is a clinical manifestation of Alzheimer’s disease, dementia with Lewy bodies and is seen in a high proportion of late stage Parkinson’s disease patients. The symptoms are associated with degeneration of synapses, the structures by which

Antidepressants associated with falls in Parkinson’s patients

Parkinson’s disease is a progressive neurological disorder that affects mobility and is commonly characterized, in advanced stages of the disease, by instability and falls. Falls are a major reason for hospitalization in Parkinson’s patients and may lead

ZNRF1: a key molecule activated by reactive oxygen species to cause neuronal degeneration

Neurons, the major component of our brain, have long processes (called “axons” and “dendrites”) to communicate with other neurons and cells. In many brain diseases that old people get suffered from, such as Alzheimer’s disease, Parkinson’s disease,

Stepping to recover from a fall is not helped by Deep Brain Stimulation in people with Parkinson’s disease

Poor balance is common in people with Parkinson’s Disease and can limit the activities people are able to engage in. If a fall occurs the injuries can be debilitating and impair quality of life. The ability to

Small or big, brain cells don’t like protein gunk that lead to diseases like Alzheimer’s, Parkinson’s and Huntington’s

An interdisiciplinary study by scientists at Trinity College Dublin (TCD, Ireland) have answered a hotly debated question in the neurodegenerative diseases research area: “Which protein aggregate form is the primary pathogenic agent in neurodegenerative diseases – (i) the prefibrillar oligomeric