Tag Archives: pathogenesis

BioID screen for bacterial virulence proteins: new tools for infectious disease research

AoS. BioID screen for bacterial virulence proteins

The discovery of penicillin in the 1920s revolutionized our ability to treat bacterial infection. However despite the introduction of antibiotics, infectious bacterial pathogens remain an immense challenge for the healthcare community. The incidence of infection by antibiotic-resistant

Dementia with Lewy bodies and Parkinson’s disease-dementia: Current perspectives

Dementia with Lewy bodies (DLB) and Parkinson’s disease-dementia (PDD) are two closely related major neurocognitive disorders with Lewy bodies of unknown etiology. Both disorders show notable overlap in their clinical presentation, pathological features, biochemistry, and genetic risk

Laser tool magnifies bacterial genotypic alteration as a colony phenotype

Gene manipulation tools are routinely used to create genetically engineered bacteria to understand the function of a gene or its role in pathogenesis in case of an infective microbe. Genetic engineering and manipulation of genes have been

Neurons share the same destiny irrespective of their location: A closer look at PP-MS pathogenesis

Multiple sclerosis (MS) is a disease of the central nervous system, caused by the reaction of immune cells against myelin, a membrane that surrounds the axons of nerve cells. MS is characterized by the presence of inflammatory

Aberrantly methylated DNA regions in IgA Nephropathy patients affect the disease

The genome can influence the onset and the development of the diseases in several manner, and in the last years several studies have revealed the new role of the DNA methylation in this framework. The DNA methylation

The roles of α2AP in the pathogenesis of systemic sclerosis

Systemic sclerosis (SSc) is autoimmune rheumatic disease of unknown etiology that is characterized by the fibrosis of skin and visceral organs, and peripheral circulatory disturbance. In our study, we found that alpha2-antiplasmin (α2AP), which is known to

What do we know and what can we do about asthma?

Asthma affects more than 300 million people of all ages and both genders worldwide and causes a huge financial burden on health systems and governments. Asthmatics have sensitive airways which over react to triggers such as allergens,

Making a better mouse model to understand the pathogenesis of respiratory syncytial virus infection

Respiratory syncytial virus (RSV) is the number one cause of infant hospitalizations in the United States. RSV infection is very common, with all children infected with this virus at least once by two years of age. Severe

Rat model of small opaque eyes open the door to eye research

Ocular diseases in elderly persons, such as cataract and age-related macular degeneration (AMD), one of the main causes of vision loss in developed nations, are paid great attention nowadays. The eye is a complicated organ constructed with

Pathogenicity of Brucella microti in chicken embryos

Brucellosis is one of the major bacterial zoonosis spread worldwide. The disease has different names: Infectious abortion, contagious abortion, enzootic abortion in animals; and Crimean fever, Mediterranean fever, Rock fever, Undulant fever or Malta fever in humans.