Tag Archives: peptide
Is multiple sclerosis triggered by immunological cross-recognition between an ancient virus and brain cell proteins?
Multiple sclerosis (MS) is an autoimmune disease where immune cells (T cells) and antibodies progressively damage the myelin sheath surrounding nerve cells leading to their loss of function. We have a reasonable understanding of the disease process
Cardiomyocyte Metabolism Research and Cardiogen Peptide
Peptide complex Cardiogen has been hypothesized to function as a bioregulator of cardiovascular function. Fibroblasts, the cells often credited with scar formation and tissue regeneration, are proposed to be the principal targets of Cardiogen in investigations. H-Ala-Glu-Asp-Arg-OH
Purification and characterization of a better-behaved Alzheimer’s disease protein
Alzheimer’s Disease (AD) is an incurable disease that causes memory, reasoning and thinking to deteriorate over time. AD is marked by brain atrophy and plaque-like deposits of a small peptide called amyloid beta (Aß) outside of brain
Access to modified peptides with heterocycle backbones using combinatorial chemistry
Applications of peptides in medicinal chemistry have several inherent limitations which can be resolved by use of peptide-like molecules. The cleavage of amide bond by proteases, low permeability, rapid metabolic processing, excretion and unwanted side effects are
Achieving synergistic biopolymer functions using systems chemistry
Biology succeeds by maintaining intricate networks of chemical and structural information far from equilibrium. The guiding premise of the highlighted manuscript1 asks whether synthetic and materials chemistry will be able to achieve a bottom-up construction of alternative
A novel synthetic approach to alternating peptides
Polypeptide with a repeating sequence has attracted particular attention as a promising candidate of innovative structural materials. Fibrous proteins such as fibroin, collagen, and elastin are the representative class among natural polypeptides with specific repeating sequence. For
Discovery of prostate cancer-specific peptides using bacterial viruses
Prostate cancer is the most common cancer and the third leading cause of cancer death among American men. Although chemotherapy has been widely used for prostate cancer treatment, it is not specific to cancer cells. As a
Targeting invasive fungi with the silver-bullet peptide
The incidence of resistance to antibiotics from infections is rising with new therapies and strategies required. One recent approach has been to combine antimicrobial silver and antibiotics such as vancomycin to combat infections. However, since antibiotics and
Trapping copper with peptides to diminish metal-related toxicity in Alzheimer’s disease
Metals are essential in many life processes and, as such, all organisms including our body have developed mechanisms for their uptake and tight regulation to achieve a normal functioning. Failure of these mechanisms is reflected in the
