Tag Archives: peptide

Purification and characterization of a better-behaved Alzheimer’s disease protein

AoS. Purification and characterization of a better-behaved Alzheimer’s disease protein

Alzheimer’s Disease (AD) is an incurable disease that causes memory, reasoning and thinking to deteriorate over time. AD is marked by brain atrophy and plaque-like deposits of a small peptide called amyloid beta (Aß) outside of brain

Access to modified peptides with heterocycle backbones using combinatorial chemistry

Applications of peptides in medicinal chemistry have several inherent limitations which can be resolved by use of peptide-like molecules. The cleavage of amide bond by proteases, low permeability, rapid metabolic processing, excretion and unwanted side effects are

Achieving synergistic biopolymer functions using systems chemistry

Biology succeeds by maintaining intricate networks of chemical and structural information far from equilibrium. The guiding premise of the highlighted manuscript1 asks whether synthetic and materials chemistry will be able to achieve a bottom-up construction of alternative

A novel synthetic approach to alternating peptides

Polypeptide with a repeating sequence has attracted particular attention as a promising candidate of innovative structural materials. Fibrous proteins such as fibroin, collagen, and elastin are the representative class among natural polypeptides with specific repeating sequence. For

Discovery of prostate cancer-specific peptides using bacterial viruses

Prostate cancer is the most common cancer and the third leading cause of cancer death among American men. Although chemotherapy has been widely used for prostate cancer treatment, it is not specific to cancer cells. As a

Targeting invasive fungi with the silver-bullet peptide

The incidence of resistance to antibiotics from infections is rising with new therapies and strategies required. One recent approach has been to combine antimicrobial silver and antibiotics such as vancomycin to combat infections. However, since antibiotics and

Trapping copper with peptides to diminish metal-related toxicity in Alzheimer’s disease

Metals are essential in many life processes and, as such, all organisms including our body have developed mechanisms for their uptake and tight regulation to achieve a normal functioning. Failure of these mechanisms is reflected in the