Tag Archives: Prostate cancer
Turning on neuronal gene programs in prostate cancer cells
Cancer of the prostate gland is a common malignancy afflicting males worldwide. This cancer is the second deadliest amongst male in United States, with most of the mortality resulting from aggressive, advanced stage, metastatic disease. Prostate cancer
Harbinger of increased prostate cancer risk: The effect of decreased prostate cancer screening
Since the introduction of prostate-specific antigen (PSA) as a blood test in 1992, the number of men diagnosed with prostate cancer increased dramatically. Because PSA detects men who are asymptomatic two things occurred. First, many of the
Targeting cholesterol metabolism to suppress prostate cancer metastasis
Metastatic prostate cancer is the second leading cause of cancer death in men worldwide. Prostate cancer itself is one of the most common cancers in men. At the early stages, localized prostate cancer usually grows slowly and
Enrichment, quantification and glycan analysis of prostate cancer oncomarker in a single step
In recent decades, there is an increasing trend in prostate cancer occurrence and mortality worldwide, caused partly by a more available diagnostics, prolonged life period but also increased risk factors present in the environment. Most commonly, age
Fasting blood glucose and prostate cancer: A meta-analysis of dose-response
Prostate cancer (PCa) is the most common cancer, and third leading cause of cancer deaths, in American men. So far, only a few well-established risk factors, including ageing and being racially black, are thought to be associated
Multi-scale mechanical characterization of prostate cancer cell lines
Cellular mechanics are of prime importance in the birth and the evolution of tumors towards increasingly aggressive stages and are often proposed as potential biomarkers to evaluate metastatic potential. Mechanical properties of two human prostate cell lines,
Lower TSH and higher free thyroxine predict incidence of prostate but not other common cancers
The pituitary gland signals production of thyroid hormones by the thyroid gland through secretion of thyrotropin (TSH). There are two types of thyroid hormones produced by the thyroid gland. These include thyroxine (T4) and tri-iodothyroinine (T3). These
Understanding how liposome composition and manufacturing affect docetaxel encapsulation and cell killing
Docetaxel (DTX) belongs to a class of anticancer drugs clinically used to treat a plethora of cancers, including breast and prostate cancer. DTX works by interfering with the cell cycle and blocking cell proliferation. Although being a
Scientists don’t have to travel alone; solutions can come from the crowd
Science is sometimes perceived as a lonely affair where a lone genius strives to break the code that will unlock hidden knowledge deep inside the data. Without question the contributions of great scientists are of value, but
Application of ultrasensitive electrochemical biosensors for specific analysis of a glycan on a prostate-specific antigen
Prostate cancer (PCa) is the second most common cancer worldwide, accounting for more than 1.1 million cases in 2012. The statistics says, that about 1 man in 7 will be diagnosed with PCa during his lifetime with
Alcohol and prostate cancer risk
In a large follow-up study, we found that heavy regular alcohol consumption and binge drinking during midlife were associated with a significantly increased risk of prostate cancer risk. Specifically, men who were heavy drinkers (>14 drinks/week) were
Focal salvage for radiorecurrent prostate cancer
Patients primarily treated with radiotherapy for prostate cancer can get a recurrence. The tumour then regrows. Often this is a localised process and the tumour has not spread to other parts of the body. Therefore, these patients
Androgen receptor; a tale of two cancers
Prostate cancer and breast cancer share similarities as hormone related cancers with a wide range of heterogeneous settings. Macklin, as early as 1954, provided evidence for a significantly higher frequency of prostate cancer among relatives of breast
Three dimensional quality assurance protocol for thoracic and genitourinary radiation therapy
After cancer diagnosis one treatment option is the use of external radiation. As the radiation traverses the patient it deposits most of its energy in the tumor, which causes irreparable damage to the cancer cells. One type
Ultrasensitive detection and glycan analysis of a prostate cancer biomarker
In recent years we have seen an increased frequency of diagnosed prostate cancer (PCa) cases accompanied with an enhanced mortality worldwide. Symptoms of an early-stage PCa can be mild or even absent, thus there is an urgent
Radiotherapy for prostate cancer: restrictions for the treatment of recurrent disease
Patients with prostate cancer who are treated with radiotherapy are not always cured. Depending on their pre-treatment risk factors (most importantly the stage of the tumour), they are at risk of recurrent disease. These recurrences often present
Rising from obscurity: 11β-hydroxy-androstenedione under the spotlight
Steroid hormones are small molecules that act as messengers in our bodies, regulating normal development and impacting on disease. These hormones are produced from cholesterol by the actions of enzymes− proteins which change cholesterol to form new
Undertreatment of men in their seventies with aggressive prostate cancer
Prostate cancer may be cured by either surgery or radiation treatment, but these “radical treatments” often cause permanent side effects that negatively affect the quality of life. Small prostate cancers usually grow very slowly, so more elderly
The protective role of estrogens in prostate cancer and its relationship with the SCF/c-KIT system
Prostate Cancer (PCa) is the most common oncological disorder in men worldwide, mainly affecting individuals over the age of 50. Therefore, the population aging and the improved expectancy of life have been contributing to the increased incidence
Regucalcin controls prostate cell proliferation and glycolytic metabolism
Regucalcin (RGN) is a protein with multiple functions and facets, which seems to play an important role in tissue cell homeostasis by regulating the equilibrium between cell survival/proliferation and death, and also in the control of cell
