Tag Archives: proteomics
Deep Molecular Profiling to understand the biology of Alzheimer disease
Alzheimer disease (AD) is a complex, polygenic disease with genetic, cellular, pathologic, and clinical heterogeneity. Advances in high-throughput sequencing and omics technologies have accelerated the drive toward personalized medicine. Human bio-specimens using these high-throughput platforms have emerged
Alterations in mitochondrial metabolism induced by chronic fluoride exposure
Fluoride (F) is widely available in nature and has been successfully used to control dental caries worldwide. In addition, beneficial effects have been shown on the development of teeth and bones. However, high concentrations of F over
Human protein phosphatases: Proteomic insights
Protein phosphorylation-dephosphorylation, carried-out by kinase and phosphatases respectively, serves as major regulatory switch for controlling nearly all signaling processes. So far, the kinases remained a centerpiece in driving the functional response to signaling changes. However, more recently,
Simultaneous glucose fasting and autophagy inhibition enhances chemotherapy treatment
If you could cut your risk of developing cancer, diabetes, and heart disease, rejuvenate your immune system, and potentially live longer – would you do it? What if the answer to potentially save your life is as
Proteome view on how leukemia cells communicate with their environment to escape chemotherapy
Relapse continues to pose a major challenge to successful chemotherapy of adult acute myeloid leukemia (AML). Even though 80% of AML patients achieve remission, in which the bone marrow is virtually clear of leukemic cells, still almost
Intracellular/surface proteins in pathogens: Another purpose in another place?
Bacteria use proteins on their surface to interact with host cells and tissues during infection. Proteins on the bacterial cell surface can also be good targets for developing new vaccines. The significance of surface proteins prompted many
Parallel Reaction Monitoring: A targeted mass spectrometry method
Mass spectrometry has emerged as a highly sensitive technique to study proteins and proteomes. Proteome is an entire repertoire of proteins in its various forms present in a cell, tissue or an organism. The study of proteome
How to spot a sick cell?
Mass spectrometry (MS) is a technique used to measure the mass of molecules. Chemists extensively use this method to confirm that they have made the right molecule by comparing the mass of the actual product with the
Can we create easy-to-use software to capture the complex behaviors of proteins?
Proteomics is the large-scale study of proteins enabled by mass spectrometry technology. Much like a fingerprint can place someone at a scene despite the lack of an eye witness, a mass spectrometer records protein fingerprints that are