Tag Archives: proteomics

Deep Molecular Profiling to understand the biology of Alzheimer disease

AoS. Deep Molecular Profiling to understand the biology of Alzheimer disease

Alzheimer disease (AD) is a complex, polygenic disease with genetic, cellular, pathologic, and clinical heterogeneity. Advances in high-throughput sequencing and omics technologies have accelerated the drive toward personalized medicine. Human bio-specimens using these high-throughput platforms have emerged

Rethink before taking extra amino acid supplements

AoS. Rethink before taking extra amino acid supplements.

Diet is important to fuel growth and cellular machinery and thus, plays an important role in the survival of a living organism. One of the important components of our diet is protein, which is made of different

Alterations in mitochondrial metabolism induced by chronic fluoride exposure

AoS. Alterations in mitochondrial metabolism induced by chronic fluoride exposure.

Fluoride (F) is widely available in nature and has been successfully used to control dental caries worldwide. In addition, beneficial effects have been shown on the development of teeth and bones. However, high concentrations of F over

Human protein phosphatases: Proteomic insights

Protein phosphorylation-dephosphorylation, carried-out by kinase and phosphatases respectively, serves as major regulatory switch for controlling nearly all signaling processes. So far, the kinases remained a centerpiece in driving the functional response to signaling changes. However, more recently,

Simultaneous glucose fasting and autophagy inhibition enhances chemotherapy treatment

If you could cut your risk of developing cancer, diabetes, and heart disease, rejuvenate your immune system, and potentially live longer – would you do it? What if the answer to potentially save your life is as

Proteome view on how leukemia cells communicate with their environment to escape chemotherapy

Relapse continues to pose a major challenge to successful chemotherapy of adult acute myeloid leukemia (AML). Even though 80% of AML patients achieve remission, in which the bone marrow is virtually clear of leukemic cells, still almost

Intracellular/surface proteins in pathogens: Another purpose in another place?

Bacteria use proteins on their surface to interact with host cells and tissues during infection. Proteins on the bacterial cell surface can also be good targets for developing new vaccines. The significance of surface proteins prompted many

Parallel Reaction Monitoring: A targeted mass spectrometry method

Mass spectrometry has emerged as a highly sensitive technique to study proteins and proteomes. Proteome is an entire repertoire of proteins in its various forms present in a cell, tissue or an organism. The study of proteome

How to spot a sick cell?

Mass spectrometry (MS) is a technique used to measure the mass of molecules. Chemists extensively use this method to confirm that they have made the right molecule by comparing the mass of the actual product with the

Can we create easy-to-use software to capture the complex behaviors of proteins?

Proteomics is the large-scale study of proteins enabled by mass spectrometry technology. Much like a fingerprint can place someone at a scene despite the lack of an eye witness, a mass spectrometer records protein fingerprints that are