Tag Archives: rat

Therapy of osteoporosis by the transdermal formulation based on raloxifene nanoparticles in ovariectomized rat

Osteoporosis results from insufficient post-menopausal estrogen levels and collapse of the balance between osteoclasts and osteoblasts, and the osteoporosis is a common systemic skeletal condition that is related to low bone mineral density and pathological fractures. The

Painkillers to treat schizophrenia or dementia?

Painkillers to treat schizophrenia or dementia? AoS

Schizophrenia affects about 1 % of general population and may significantly reduce life expectancy. Drug nonadherence remains a crucial problem in the pharmacotherapy of this disorder. Animal and clinical studies results suggest that abnormal kynurenic acid (KYNA)

3D-printed chitosan scaffolds for the improved in-vivo wound healing in diabetic rats

In the tissue engineering context, fabrication of porous three dimensional (3D) printed chitosan (CH) scaffolds for skin tissue regeneration and their behavior in terms of biocompatibility, cytocompatibility and toxicity toward human fibroblast (Nhdf) and keratinocyte (HaCaT), was

Binge eating increases compulsivity through dopamine mechanisms in the oval bed nucleus of the stria terminalis

Binge eating increases compulsivity through dopamine mechanisms. AoS

Binge eating is a common feature of disordered eating and the defining characteristic of binge eating disorder (BED), the most prevalent of all eating disorders. Binge eating, with or without a psychiatric diagnosis, is a likely contributor

Myocardium contractility: effects of subchronic lead intoxication in rats

Myocardium contractility. AoS

A moderate subchronic lead intoxication was observed in outbred male rats after repeated intraperitoneal injections of lead acetate during 5 weeks. Half of so exposed and control rats where given a calcium preparation with fodder. The next

Can glucose or fructose consumption impair memory?

Can glucose or fructose consumption impair memory

The intake of simple sugars in the human diet has risen in the last decades, especially due to the elevated consumption of sugar-sweetened beverages. This increase in simple sugar consumption has been associated with metabolic pathologies, such

What response of skin blood flow in hindlimb does electrical stimulation of forelimb induce?

The nervous system includes the central nervous system (CNS) and autonomic nervous system (ANS). Abundant evidence exists to show that structures and functions of the CNS in humans are bilaterally asymmetrical. The best known example of brain

Neuropetides and adipose-derived mesenchymal stromal cells improve peripheral nerve regeneration in animal model

Although autologous nerve grafting remains the gold standard for nerve gap repair, entubulation techniques with artificial nerve conduits are considered a promising approach to peripheral nerve reconstruction (Strauch, 2000). Advances in bioengineering have led to the creation

Does thyroid hormone deficiency in fetal life have adverse effects on cardiovascular system during adulthood?

Proper development of fetus depends on its genetics as well as the hormonal, metabolic, and nutritional environment provided by the mother. Deficiency of thyroid hormones (THs) at birth is considered as congenital hypothyroidism and the prevalence of

Rodent cochlear nucleus – the common and the uncommon

Our perception of environmental sounds depends on the function of our ears. Sound vibrations received by each of our two ears are converted to electrical signals in the cochlea part of the inner ear. The electrical signals

Why is anxiety more common in women? Investigating sex differences in threat and safety learning

Anxiety-related disorders like post-traumatic stress disorder (PTSD) are up to twice as common in women as in men but the reasons behind this remain unclear. People with PTSD often experience negative emotions like fear when reminded of

Rat speech patterns predict future alcohol use and reveal past alcohol experience

Heightened emotional states increase impulsive behaviors such as excessive alcohol drinking in humans.  However, very few animal studies have focused on the role of emotional status as a motivator of alcohol drinking.  This is a major roadblock

Blockade of estrogen receptor alpha mitigates alcohol-evoked myocardial dysfunction in female rats

Recent evidence challenges the longstanding view that light-to-moderate alcohol drinking might confer cardioprotection, and the latter is mostly based on population studies in men or in male experimental animals. However, while the reduction in blood pressure caused

From the gut to the eye: commensal microbes as potential triggers of autoimmune uveitis

Autoimmune uveitis is a group of inflammatory diseases that affect the retina of the eye and related tissues and constitute a major cause of human blindness. It is believed that the disease is triggered by the activation

The effect of a hydrogen sulfide releasing molecule on the cold storage of livers from dead donor rats

The liver is the largest organ inside our body and, as long as it keeps healthy, it will be in charge of a wide range of mechanisms that are essential for life. Liver will filter the blood

Sex, salt, and the central nervous system: estrogen and body sodium balance

Historically, research about reproductive hormones like estrogen has focused on reproduction and reproductive behaviors. Certainly, this focus is understandable; however, it is becoming increasingly obvious that estrogen plays a broader role . In fact , estrogen profoundly

Effect of exercise duration and exercise withdrawal on memory consolidation trend

The beneficial effects of exercise on the physiologic systems, brain, and mental health are well-established. Also, the maintenance of a healthy central nervous system throughout life serves as an imperative public health goal. Evidently, exercise can help

Epileptic rats as perfect models to understand epilepsy?

Epilepsy is a neurological disease that affects about 1% of the population in the world, most of them being children and teenagers. Animals suffering from epileptic seizures can also be found in several species (dogs, cats, chicken,

The sound of one hand clapping

Combat in the animal kingdom is pervasive. Animals fight to gain mates, food and suitable places to rest and they fight to protect what they have, be it food or young. But with fighting there is risk,