Tag Archives: regeneration
MicroRNAs control cellular transition of hepatocytes during liver regeneration
Among adult organs, the liver is unique in its intrinsic ability to regenerate after injury through the proliferation of fully differentiated cells. Hepatocytes, which are the most abundant type of cells in liver, are quiescent and rarely
Regeneration evolved in anamniotes in relation to metamorphosis: indications for attempts to induce limb regeneration in humans
The amazing capability of anamniotes, amphibians and fish, to regenerate limbs, tails, spinal cord, eyes, intestine, heart etc. contrasts with loss of organ regeneration in amniotes: reptiles, birds and mammals. Studies generally neglect to consider the life
Immune damage of Apical Epidermal Cap impedes limb regeneration in frog
The evolution of the immune system in terrestrial vertebrates has allowed a high efficiency in the protection against mutated and cancer cells, foreign substances and microbes. Immune cells however become fully immunocompetent only late during development or
Building and rebuilding gastric epithelium: Trop2 as a common denominator
In mammals, the stomach is lined by a contiguous layer of cells called epithelium, further organized into units called glands. Gastric glands are divided into two areas: corpus and antrum, according to their specific function depending on
Fine tuning of inflammation is a key to successful limb regeneration
Complete regeneration of appendages after amputation in certain fish and amphibians has long served as a useful model for analyzing why regeneration is unsuccessful in most mammalian organs. Recent work with zebrafish, frog tadpoles, salamanders, reviewed in
Building a matrix mediated cell expansion system for high-quality cartilage regeneration
Articular cartilage is a tissue found in joints throughout the body (knees, elbows, etc.) that plays a significant role in allowing the body to maintain proper movement and engage in physical activities; it also supports the transfer
Quorum sensing concept shed new lights on the collective regenerative behavior through study of hair plucking
Scientists know injuries sometime induce regeneration sometime not. Scientists search for factors that can promote regeneration. Usually, regeneration process is studied by analyzing the regenerative behavior of one organ unit. However, this may not be sufficient to
Overcoming aging-caused difficulties in salivary gland
Stem cells are the cells that are responsible for the maintenance of tissues and organs by replacing functional cells with a limited life-span or that are damaged beyond repair. Over the last decades stem cells have been
Measuring what cells feel using the nano-epsilon dot method
When we walk on the sand, a trampoline or a concrete pavement, we can feel the hardness, softness and springiness of the ground and respond by changing the way we move. The way we respond depends on
How do neurons develop and regenerate?
Identifying how neurons form a functioning network provides the background for knowing how to manage, treat, and prevent neurological disorders, as well as promote healing after injury to the nervous system. NICHD researchers uncovered a new pathway
New biomimetic materials for muscle regeneration
Skeletal muscle formation derives from a coordinated sequence of molecular and cellular changes, ultimately leading to the expression of large, multinucleated contractile fibers, characterized by a highly ordered assembly of striated myofibrils. To form contractile fibers, developing
