Tag Archives: rheumatoid arthritis
Diagnostics of seronegative rheumatoid arthritis using glycomic tools and machine learning
Rheumatoid arthritis (RA) is an inflammatory disease characterized by synovium swelling and destruction. There are two different types of rheumatoid arthritis, sometimes even believed to be two distinct disorders, namely seropositive (S+) and seronegative (S-) rheumatoid arthritis.
Fibroblasts in rheumatoid arthritis: From friend to foe
Our joints are composed of tissue-resident cells, called fibroblasts, which are responsible for maintaining the structure of the joint and repairing damaged tissue. Additionally, we and others have shown that fibroblasts can also influence the types and
Lung infections and the origins of rheumatoid arthritis
Five percent of individuals worldwide develop an autoimmune disease. The causes of the majority of autoimmune diseases is unknown. But it is recognised that various tissues are damaged by over-activation of our immune system in response to
Time to switch? Switching from innovator rituximab to biosimilar CT-P10 is safe and efficacious
Rituximab is a monoclonal antibody that targets the CD20 protein that is found mainly on immune cells called B lymphocytes. By removing CD20-positive B lymphocytes from the peripheral blood and bone marrow, rituximab provides effective treatment for
Long-term safety and efficacy of rituximab biosimilar CT-P10 in rheumatoid arthritis
Rituximab is a monoclonal antibody used to treat certain cancers of the blood, as well as immune-mediated diseases such as rheumatoid arthritis. But while rituximab is effective, it is also expensive, which means that not everyone who
Coffee for the relief of symptoms of methotrexate intolerance among patients with rheumatoid arthritis
Patients with rheumatoid arthritis (RA) and some of the other systemic autoimmune rheumatic diseases are commonly prescribed methotrexate (MTX) at the dose of < 25-30 mg/week. Depending upon the patient’s condition and the dosage prescribed, some patients
Gut microbiota: A potential trigger of rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder characterized by synovitis in multiple joints and systemic comorbidities. Both genetic and environmental agents are thought to be the risk factors for arthritis. Recent studies have suggested that
Current treatment for rheumatoid arthritis fails to improve patient’s body composition or physical function
Adverse changes in body composition – specifically, reduced muscle mass (MM) and increased fat mass (FM) – are characteristic of rheumatoid arthritis (RA). Indeed, when body composition is assessed, significant muscle loss is evident in ~67% and
The price of escalating drug dose to treat rheumatoid arthritis
Rheumatoid arthritis (RA) with its characteristic joint swelling, inflammation, pain and stiffness, may be treated with biologic disease-modifying drugs. One class of drug belonging to this group inhibits tumor necrosis factor (TNF), which plays an important role
Can Radon radiation become a source of treatment for Rheumatoid Arthritis?
Rheumatoid arthritis (RA) is the most common type of autoimmune disease. It is triggered by a faulty immune system of the body. However, the real cause of the disease is not completely known. The disease affects the
Clinical studies ask: “Are less expensive ‘biosimilar’ drugs as effective and safe as current drugs?”
Several debilitating diseases caused by disorders in a patient’s immune system – often called ‘immune-mediated diseases’ – have become easier to treat in the last two decades following the discovery of drugs called ‘biologics’. Biologics act on
The undiagnosed, untreated key to restoring physical function and health in rheumatoid arthritis patients
Rheumatoid arthritis (RA) is characterised by adverse changes in body composition – specifically, reduced muscle mass (MM) and increased fat mass (FM). Indeed, when body composition is assessed (i.e. MM and FM are estimated), significant muscle loss
