Tag Archives: ROS

Reactive oxygen species, Devil or Angel?

Reactive oxygen species

Reactive oxygen species (ROS) have an amazing oxidative potential with oxidative stress and could abolish the integrity of living cells. Vigorous production of ROS can damage mitochondria and DNA, which would persistently destroy the cells and might

Cellular stress and AMPK activators including metformin and the anesthetic drug propofol promote restoration of human consciousness

Cellular stress and AMPK activators including Metformin

The neural mechanisms that give rise to human consciousness have been described as one of the greatest and most profound mysteries in all of modern medicine. The use of general anesthetics to induce loss of consciousness (LOC)

Role of the gut in systemic inflammation

The multi-layer wall of the intestine is unique and important due its barrier function for billions of potential deadly gut bacteria and the sterile tissues in the body. For this reason, the intestine is equipped with highly

Unregulated oxygen levels in mammalian cell culture changes cell physiology

As aerobic organisms we continuously utilize oxygen from the surrounding environment which ultimately participates in the formation of useful bioenergetic intermediates. Approximately 21% of the air we breathe is composed of oxygen, but the quantity of oxygen

Mechanical injury in plants triggers local and long distance response using biochemical signals

It is well-known that when the mammal skin undergoes a physical injury there is a local response to repair the damage cells but, at the same time, there is also a diversity of signals that stimulate the

Effect of the new hybrid 3,5-dipalmitoyl-nifedipine on the ischemia / reperfusion simulation

The myocardial ischemia process is a global health problem. Damage after myocardial ischemia and reperfusion (I/R) is the leading cause of morbidity and mortality globally. Hypertensive patients are most affected by I/R. This work investigated the acute

How selenium tolerates arsenic toxicity in rice plant? Role of phenolics and nutrient elements in amelioration of arsenic induced phytotoxicity

Arsenic (As) contamination is a major environmental hazard of recent times which poses a health risk for human through food chain contamination. Nearly 200 million people are at risk of As toxicity. Millions of people depend on

A dual specificity protein phosphatase and redox homeostasis in plants

Man has been struggling to understand and define life since the day he became aware of it. Innumerable philosophies and findings over the history of mankind together draw the perspective with which we look at life today.

Insulin effects on pancreatic beta cells-not always what you may think

Normally, blood glucose levels are controlled within a reasonable range by the release of insulin from pancreatic beta cells in response to an increase in blood glucose levels following a meal or other glucose challenge. One of

Arsenic´s different effects under normoxia and hypoxia and its ambivalent role in cancer

Arsenic (As) is as natural contaminant in drinking water in particular in Argentina, Canada, India, Japan, China, Taiwan, Mexico, Chile, and the United States. It is best known as a toxic element which upon chronic ingestion is,

Trapping copper with peptides to diminish metal-related toxicity in Alzheimer’s disease

Metals are essential in many life processes and, as such, all organisms including our body have developed mechanisms for their uptake and tight regulation to achieve a normal functioning. Failure of these mechanisms is reflected in the

How plants survive during drought seasons? Polyphenols: the natural antioxidants

The earth has a variety of ecosystems. One of them is the semiarid regions characterized by seasonal rainfalls and long periods of drought. The native plants species of these environments have the ability to survive and maintain

‘Resurrection plants’, our ticket to crop drought tolerance?

The loss of crops or decrease in crop yields due to drought has been and still is a major natural disaster, resulting in multiple devastating humanitarian and environmental impacts. This is becoming prevalent in almost every inhabited

Direct monitoring of the interaction between ROS and cerium dioxide nanoparticles in living cells

Swallowing the pill we don’t know whether it comes to the target, destroys the harmful objects (microbes, viruses, cancer cells) and/or whether it works correctly at the center of the inflammation. Let’s imagine that each grain of

How does the antioxidant biliverdin work?

Antioxidants as food supplements are all the rage. Antioxidants include vitamins C and E and the compound family of the flavonoids, the strongly dark-blue or red-colored compounds found in fruits, such as blueberries or blackberries, or in

Nanocarrier-based antioxidant therapy: promise or delusion?

It has been well established that the damage produced by Reactive Oxygen Species (ROS), which are highly reactive molecules with an unpaired electron, plays an important role in a large number of human diseases. Because of this

Zinc – a promising supplement for the immune system

Zinc is essential for basic functions within cells of the human body. Hence, zinc deficiency is associated with impaired immune functions as dermatitis, dysfunction of the immune system, hypogonadism, and growth retardation. Under normal conditions only low

NEIL2 repairs DNA damage within active genes, maintains chromosome end integrity, prevents inflammation

Mammalian cells are subjected to a plethora of exogenous and endogenous agents that cause damage to the cellular DNA. One of the major sources of such damage is oxygen-derived molecules and free radicals, collectively termed “Reactive Oxygen

Over-expression of TRX2 reduces p53-mediated cell death in yeast

The p53 gene is a human tumor suppressor which is involved in cell cycle regulation. It has an efficient ability to inhibit cell proliferation, by both blocking cell cycle progression and promoting apoptotic cell death in order

Killing microbes with red light

Photosensitization is a process in which a chemical compound (photosensitizer) that absorbs energy from light is able to transfer that energy to oxygen molecules. As a consequence, reactive oxygen species (ROS), highly toxic to living cells, are