Tag Archives: ROS
The roles of mesenchymal stem cells secretome in diabetic wound healing
There has been a fourfold rise in the number of diabetics from 108 million in 1980 to 422 million in 2014 and by 2040 the number will reach to 642 million. Diabetes mellitus drastically influences normal functioning
A new link between oxidant stress and lung cancer
DNA repair protects our cells from conditions that cause damage to the genome, which can become a threat to the maintenance and function of our tissues. Our cells have a variety of DNA repair systems. Most frequent
The RAS mRNA G-quadruplex: making undruggable cancer targets druggable
In many cancers, RAS proteins are constitutively activated by their oncogenic mutations or activation of their upstream molecules. RAS proteins play a central role in cancer cell malignancy, and drugs that target RAS are therefore believed to
Reactive oxygen species, Devil or Angel?
Reactive oxygen species (ROS) have an amazing oxidative potential with oxidative stress and could abolish the integrity of living cells. Vigorous production of ROS can damage mitochondria and DNA, which would persistently destroy the cells and might
Cellular stress and AMPK activators including metformin and the anesthetic drug propofol promote restoration of human consciousness
The neural mechanisms that give rise to human consciousness have been described as one of the greatest and most profound mysteries in all of modern medicine. The use of general anesthetics to induce loss of consciousness (LOC)
Role of the gut in systemic inflammation
The multi-layer wall of the intestine is unique and important due its barrier function for billions of potential deadly gut bacteria and the sterile tissues in the body. For this reason, the intestine is equipped with highly
Unregulated oxygen levels in mammalian cell culture changes cell physiology
As aerobic organisms we continuously utilize oxygen from the surrounding environment which ultimately participates in the formation of useful bioenergetic intermediates. Approximately 21% of the air we breathe is composed of oxygen, but the quantity of oxygen
Mechanical injury in plants triggers local and long distance response using biochemical signals
It is well-known that when the mammal skin undergoes a physical injury there is a local response to repair the damage cells but, at the same time, there is also a diversity of signals that stimulate the
Effect of the new hybrid 3,5-dipalmitoyl-nifedipine on the ischemia / reperfusion simulation
The myocardial ischemia process is a global health problem. Damage after myocardial ischemia and reperfusion (I/R) is the leading cause of morbidity and mortality globally. Hypertensive patients are most affected by I/R. This work investigated the acute
How selenium tolerates arsenic toxicity in rice plant? Role of phenolics and nutrient elements in amelioration of arsenic induced phytotoxicity
Arsenic (As) contamination is a major environmental hazard of recent times which poses a health risk for human through food chain contamination. Nearly 200 million people are at risk of As toxicity. Millions of people depend on
A dual specificity protein phosphatase and redox homeostasis in plants
Man has been struggling to understand and define life since the day he became aware of it. Innumerable philosophies and findings over the history of mankind together draw the perspective with which we look at life today.
Insulin effects on pancreatic beta cells-not always what you may think
Normally, blood glucose levels are controlled within a reasonable range by the release of insulin from pancreatic beta cells in response to an increase in blood glucose levels following a meal or other glucose challenge. One of
Arsenic´s different effects under normoxia and hypoxia and its ambivalent role in cancer
Arsenic (As) is as natural contaminant in drinking water in particular in Argentina, Canada, India, Japan, China, Taiwan, Mexico, Chile, and the United States. It is best known as a toxic element which upon chronic ingestion is,
Trapping copper with peptides to diminish metal-related toxicity in Alzheimer’s disease
Metals are essential in many life processes and, as such, all organisms including our body have developed mechanisms for their uptake and tight regulation to achieve a normal functioning. Failure of these mechanisms is reflected in the
How plants survive during drought seasons? Polyphenols: the natural antioxidants
The earth has a variety of ecosystems. One of them is the semiarid regions characterized by seasonal rainfalls and long periods of drought. The native plants species of these environments have the ability to survive and maintain
‘Resurrection plants’, our ticket to crop drought tolerance?
The loss of crops or decrease in crop yields due to drought has been and still is a major natural disaster, resulting in multiple devastating humanitarian and environmental impacts. This is becoming prevalent in almost every inhabited
Direct monitoring of the interaction between ROS and cerium dioxide nanoparticles in living cells
Swallowing the pill we don’t know whether it comes to the target, destroys the harmful objects (microbes, viruses, cancer cells) and/or whether it works correctly at the center of the inflammation. Let’s imagine that each grain of
How does the antioxidant biliverdin work?
Antioxidants as food supplements are all the rage. Antioxidants include vitamins C and E and the compound family of the flavonoids, the strongly dark-blue or red-colored compounds found in fruits, such as blueberries or blackberries, or in
Nanocarrier-based antioxidant therapy: promise or delusion?
It has been well established that the damage produced by Reactive Oxygen Species (ROS), which are highly reactive molecules with an unpaired electron, plays an important role in a large number of human diseases. Because of this
Zinc – a promising supplement for the immune system
Zinc is essential for basic functions within cells of the human body. Hence, zinc deficiency is associated with impaired immune functions as dermatitis, dysfunction of the immune system, hypogonadism, and growth retardation. Under normal conditions only low
