Tag Archives: sclerosis

RNA signature in brain lesions of damage or repair in Multiple Sclerosis and the MS-Atlas

AoS. RNA signature in brain lesions of damage or repair in Multiple Sclerosis and the MS-Atlas

We explored mechanistic signatures of different lesion types in the brain of patients with progressive MS: normal-appearing white matter (NAWM), active, chronic active (slowly expanding), inactive and repairing (remyelinating) lesions compared to control brain white matter areas.

Circulating fibrocytes as possible new target of abatacept effect in systemic sclerosis patients

Circulating fibrocytes as possible new target. AoS

Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by microvascular and immune response alterations followed by a progressive fibrosis, which is the consequence of an excessive production and deposition of extracellular matrix molecules, primarily fibronectin

Nailfold microangiopathy in dermatomyositis and systemic sclerosis: what is different in long term follow-up?

Nailfold videocapillaroscopic pictures. AoS

Dermatomyositis (DM) is a chronic inflammatory disorder involving mainly the skin and muscles. Systemic Sclerosis (SSc) is an autoimmune rheumatic disease of unknown etiology characterized by vascular alterations and progressive tissue fibrosis of multiple organs. Peripheral microangiopathy

How well can serum miRNAs diagnose amyotrophic lateral sclerosis patients?

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that damages motor neurons. As the disease progresses, patients gradually loose exercise capacity. Finally, they die due to the lack of breathability. No effective therapy was found for ALS

Inhibitors of intracellular enzymes for treatment of multiple sclerosis

The protein kinase inhibitor imatinib

Lymphocytes are white blood cells that are central in the immune response to foreign microorganisms. Like all cells, lymphocytes have a membrane, a lipid bilayer, that envelops the content of the cell. Proteins attached to the cell

Multiple sclerosis diagnosis from cerebrospinal fluids via infrared spectroscopy with chemometrics

Multiple sclerosis (MS) is a chronic, demyelinating and degenerative disease of central nervous system (CNS), characterized by an autoimmune inflammation. Approximately 2.5 million people in the world are affected from multiple sclerosis which is one of the

Capillary number in the “late” pattern correlates with the progression of organ involvement in systemic sclerosis

Systemic Sclerosis (SSc) is an autoimmune rheumatic disease characterized by vascular alterations and tissue fibrosis of multiple organs. Vascular structural alterations are detected early and seem to play an important role in SSc pathogenesis. Microvascular damage is

Epigenetics and multiple sclerosis

Genetic studies have long been trying to describe the etiopathology of human diseases. Even though the cutting-edge approaches like whole human genome sequencing and genome wide association studies have largely improved our apprehension, there are numerous questions

A capillaroscopy based method to help prediction of Systemic Sclerosis onset

Systemic Sclerosis (SSc) is a rare systemic disease, characterized by immune system alterations and diffused microvascular disruption, followed by fibrosis of skin and internal organs, and Raynaud’s phenomenon (RP) is often the first clinical manifestation of the

The roles of α2AP in the pathogenesis of systemic sclerosis

Systemic sclerosis (SSc) is autoimmune rheumatic disease of unknown etiology that is characterized by the fibrosis of skin and visceral organs, and peripheral circulatory disturbance. In our study, we found that alpha2-antiplasmin (α2AP), which is known to

A cysteine residue is a key commander of SOD1-related neuronal toxicity in ALS

Amyotrophic lateral sclerosis (ALS; a.k.a. Lou Gehrig’s disease) is a life-threatening disease of motor neurons that gradually affects muscle strength of the whole body. The disease occurs familially in some cases, and 25 to 30% of the

Demyelination and remyelination signalling in multiple sclerosis as an aid to targeted therapy

Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system (CNS) characterised by demyelination. Demyelination, i.e. damage and erosion of the myelin sheath which protects the nerve fibres, occurs in the white matter of

Agreement between physician’s recommendation and fitness-to-drive decision in multiple sclerosis

Multiple sclerosis (MS) is a progressive disease of the central nervous system with potential debilitating effects on visual, motor and cognitive functions. These functions are essential for daily life activities, such as driving a car. Previous studies

Does immunotherapy in Multiple Sclerosis increase the risk of developing PML?

Progressive multifocal leukoencephalopathy (PML) is a rare and life-threatening brain disease caused by the JC virus. In multiple sclerosis (MS), natalizumab (Tysabri, Biogen) was already known to substantially increase the risk for PML by suppressing the immune

A small structure hidden in the brain that might play a big role in diseases like depression and autism

The choroid plexus is a hidden and often neglected, but important, structure in the brain. The choroid plexus hangs inside the brain ventricles which are filled with cerebrospinal fluid (CSF) (Fig. 1). Importantly, the choroid plexus is

Oligodendrocyte Tau’s failed quest for microtubules results in myelin decrease and falling

Oligodendrocytes make a good-sized myelin that surrounds axons and allows humans to walk and see. In contrast, when axons do not get enough myelin, axonal function is incapacitated, with resulting deficits in cognition, behavior, and in the

Blood-based biomarkers for multiple sclerosis

Multiple sclerosis (MS) is an immune-mediated, inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS). MS is classified in: relapsing–remitting (RRMS), characterized by acute attacks followed by partial or complete recovery periods; primary progressive (PPMS),