Tag Archives: signaling
Method to measure calcium signaling in nanometer-sized primary cilia
Cilia are slender microtubule-based organelles that protrude from the apical membrane in most adherent cells. Studies looking into the mechanosensory function of the primary cilium have proved it to be an essential cellular organelle. When exposed to
Receptors talking: solo vs chorus
Multi-cell organisms, including humans, need reliable and timely communication between cells to function. Every cell is surrounded by the plasma membrane made of lipids, which separates it from the environment. Receptors localized on that membrane are proteins
Do you want a specific signal? Go local! Imaging our way to targeted therapy
Cyclic adenosine monophosphate (cAMP) is a ubiquitous intracellular second messenger, a small molecule that conveys the information carried by hormones, neurotransmitters and other extracellular stimuli to the intracellular environment. cAMP is generated at the plasma membrane when
The cellular protein (cFLIP) downregulates IFN-alpha, a signaling protein involved in the pathogenesis of SLE
Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disorder that manifests itself within various organs of the body. It is observed in women more often than men. While clinical presentations may vary widely, hallmarks of SLE include
The NO-heme signaling hypothesis
The importance of the NO-synthase(NOS)/soluble guanylyl cyclase (sGC) signaling for health and disease is undisputable (Nobel Prize in Biology and Medicine, 1998). Many studies demonstrated that this pathway is critically implicated in the regulation of cardiovascular, nervous,
Emerging roles of cyclic nucleotide gated channels in plants
Plants are vulnerable to various biotic and abiotic stresses imposed in their respective growth environment. These stresses negatively affect the normal growth, development and productivity. Unlike animals, which can move to conditions conducive for growth and development;
Phospholipase C break membrane lipids during plant adaptation under stress
Plants constantly encounter various biotic and abiotic stresses in the environment. These stresses present adverse growth conditions, which affect the plant development, longevity and productivity. The crop production is decreasing rapidly due to the negative impact of
The matrix reloaded: how a self-produced extracellular matrix controls the development of multicellular microbial communities
In nature, many bacteria live in multicellular communities called biofilms. Biofilms offer their resident bacterial cells protection from environmental insults and assaults, and better attachment to hosts. For humans, they have medical and industrial costs, but also
