Tag Archives: stem cell

In the pursuit of personalized medicine; New technologies to study the gut microbiome

Humans have a symbiotic relationship with microbes that reside in and on our bodies.  The human digestive tract contains as many as 1014 of bacterial cells, making it one of the densest and most diverse microbial communities

Image Cytometer – NucleoCounter® NC-3000™

The NucleoCounter® NC-3000™ is an advanced image cytometer utilizing fluorescence imaging to characterize cell properties. The NC-3000™ can perform high speed cell count and viability determination and includes plug-and-play analytical assays of mammalian, yeast and insect cells.

Viable stem cells can survive in horse’s ligaments up to 72 hours after death

Adult mesenchymal stem cells (MSCs) are being used in today’s clinical practice to regenerate or replace the damaged tissue. Moreover, both autologous and allogenic MSCs have been shown to be effective for tissue repair after injury and disease.

The key key to open the door of iPSCs clinical therapy for patients

The discovery of iPSCs is probably one of the most astonishing accomplishments in the beginning of 21st century. This is by 4 early protein factors, the differentiated cells–such as fibroblasts, T and B cells—can return to pluripotent

Building a matrix mediated cell expansion system for high-quality cartilage regeneration

Articular cartilage is a tissue found in joints throughout the body (knees, elbows, etc.) that plays a significant role in allowing the body to maintain proper movement and engage in physical activities; it also supports the transfer

What stem cells have to do with stomach cancer

The surface of the stomach is lined by a delicate single-layered sheet of epithelial cells (termed the gastric mucosa and its glands), which represents a tight barrier to the outside world (i.e., the gastric juice and its

A novel approach to identify primitive CD34+ stem cells

Stem cells are important for living organisms for many reasons, as they are capable of renewing themselves as well as to expand to repair and regenerate damaged tissues. Adult stem cells exist throughout the body after embryonic

CML – where do we stand in 2015?

The progress with CML‐treatment continues at a rapid pace. Treatment of choice is targeted therapy with tyrosine kinase inhibitors (TKI). Five‐year survival ranges around 91% and 10‐year survival around 84% up from 11% with Busulfan 30 years ago. More

Inhibitors of gastric acid secretion and gastric cancer

The highly acidic gastric juice is an efficient killer of swallowed microorganisms. This is an important function which is reflected in the tight regulation of gastric acidity involving both nerves and hormones (blood born messengers). The most

Overcoming aging-caused difficulties in salivary gland

Stem cells are the cells that are responsible for the maintenance of tissues and organs by replacing functional cells with a limited life-span or that are damaged beyond repair. Over the last decades stem cells have been

Small molecule antagonists maintain stem cell potency

The decision for a stem cell to make an exact copy of itself and maintain the same level of potency versus initiate a differentiation program is critical both during development and normal tissue maintenance. CBP and p300

The interplay of the ticking clock and miRNA in differentiation of endothelial precursors

Our day-today activities like sleep-wake cycle, hormone release, body temperature and other important bodily functions follow a characteristic rhythm over 24 hours called a circadian rhythm. A ‘master clock’ in brain termed as suprachiasmatic nucleus (SCN) co-ordinates

Cardiac atrial appendage stem cells: bright cells for a bright future for patients with ischemic heart disease

Ischemic heart disease is still one of the major causes of global morbidity and mortality. Although significant improvements in medical and surgical treatments have been accomplished over the last few decades, these are still not able to

The fossil viruses from within that shape evolution

Our genome contains a colossal amount of virus-related sequences. Over 4 million fragments of our DNA derive from mobile genetic elements, some of which once were viruses that infected the germ line (egg or sperm cells) of

Mitochondrial activity is different in different sub-regions of the human amniotic membrane

What is the first image a human being probably sees? Provided a fetus could see, it would see the inner lining of the uterus, the so called amniotic membrane. The amniotic membrane consists of two layers, the