Tag Archives: stem cells
Modulating the distribution and fate of MSCs following therapeutic delivery may enhance their efficacy
Mesenchymal stem/stromal cells (MSCs) can be isolated from multiple adult tissues and have been shown to produce factors which can protect cells from diverse injurious stimuli, favourably modulate the immune response, and enhance tissue reparative and regenerative
Reprogramming skin into brain to study aging and age-related brain diseases
“Inevitable as the passing of time” is a common phrase and a simple truth; in our lives, we may have impactful experiences, grow and learn but, inescapably, we age. It is clear that as we age, our
MS Treatment Experience at Swiss Medica: “I’ve Got My Life Back”
Posted by Anna Nadiryan embryologist, cell biologist, medical writer This story is told by Shaun Lawrence from the UK, who was diagnosed with relapsing-remitting multiple sclerosis in 2009. His right leg was aching so much that he
Stem cells and stem cells conditioned medium for inflammatory bowel disease treatment
Inflammatory bowel disease (IBD) is a complex of pathological processes occurring in the intestine. Chemically induced IBD in rodent usually used for study of drug therapy efficacy. Mesenchymal stem cells (MSC) was used as alternative method for
Building an artificial kidney from human stem cells
Many diseases and drugs affect kidney function by damaging the glomeruli — the major site of blood filtration and a target for many diseases. An in vitro model of the human glomerulus could facilitate therapeutic discovery and
Treatment critical limb ischemia with intramuscular administration of mesenchymal stem cells
Critical limb ischemia (CLI) is a severe form of peripheral artery disease, and associated with high rate of morbidity and mortality. The current standard for treatment CLI is revascularization. However, in any time surgical or endovascular revascularization
Bone marrow chilling could warm the body
In order to keep warm during cold exposure, heat production must be increased. This can be achieved through non-shivering and shivering thermogenesis. The main tissue involved in non-shivering thermogenesis is brown adipose tissue (BAT) which is located
FTIR spectroscopy and ımaging to understand donor age effect on bone marrow mesenchymal stem cells
Stem cells, like Bone Marrow Mesenchymal Stem Cells (MSCs), have enormous potential to develop new therapies for tissue regeneration and repair with their ability to differentiate into many different types of cells. The aging process and the
Under pressure: a stem cell’s journey home
Hyperbaric oxygen therapy (HBOT) involves breathing in pure oxygen at an air pressure three times higher than atmospheric pressure. This allows more oxygen to enter the lungs, dissolve into the circulation, and ultimately reach cells. The future
Making mountains out of molehills: how stem cells become platelets
You have 100,000 km of plumbing (blood vessels) in your body. What then keeps them from leaking? This essential work is carried out by tiny cells called platelets, which are able to form a plug to stop
The importance of immature cancer cells in predicting patient outcome
The word “cure” for breast or any other type of cancer might be unfair to a patient since this will give the individual a false sense of comfort. The misuse of `cure’ is evident in breast cancer
How can you tell that stem cells are good at math? You can watch them multiply and divide!
Blood production is an essential process in all vertebrate animals that needs to occur throughout an organism’s lifespan; red blood cells need to carry oxygen to distant tissues, platelets are required for stopping bleeding after injuries, and
Tissue-specific MED1 LxxLL motifs play critical roles in HER2-driven breast cancers
Estrogen Receptor (ER) is a nuclear hormone receptor that plays important roles in normal mammary gland development as well as breast cancer growth and metastases. In a breast cancer setting, when ER is bound by estradiol, there is
Stem cells accept the degradation products of Poly (ε-caprolactone)
One of the serious health issues experiencing by humans in the world are accidental injuries and associated complications. Treatment strategies for these injuries are depending on their severity and age of the person gets injured. Among this,
Better implants with stem cells
Prosthetic implants are used day-to-day to treat edentulous people and patients in need of skeletal reconstructions. The history of prosthetic dental implants dates back thousands of years, with the early civilizations using seashells and stones to replace
Understanding cardiac arrhythmias using an embryonic stem cell model
Embryonic stem cells are pluripotent and have the capability to differentiate into almost all cell types of the body. Thus, they offer great potential for regenerative medicine such as cell-based therapies and basic research purposes including disease
Recurrent ontogenesis
Flowering plants arose during the Cretaceous, and up to date they count around 235,000 species, representing the largest and most diverse group within the plant kingdom. One of the foundation of their success relies upon the production
Pancreatic cancer stem cells: fatty acid synthesis and mevalonate pathways are implicated in their survival
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high metastatic potential. The disease is the fourth leading cause of cancer-related deaths in the USA, and is projected to be the second one by 2030, due
The use of bone marrow-derived mononuclear cells ameliorates airway inflammation in horses with recurrent airway obstruction
Horses stabled indoors live in a pro-allergenic environment and are exposed to molds, mites, and bacterial endotoxins from hay and bedding. This exposure exacerbates recurrent airway obstruction (RAO), an asthma-like disease. Affected horses suffer from recurrence of
A predictive approach for nanotoxicity assessment using stem cells
Advance in nanotechnology has prompted the science world to recognize the risk and potential health effects associated with the growing as well as incongruous use of nanoparticles. The current methods often employ a predictive toxicology approach that
