Tag Archives: T cell
Can we treat cancer by targeting Treg subset without causing autoimmune disease?
The regulatory T cells (Tregs), are a type of CD4+ T cells that suppress the potentially adverse effect of the immune system and prevent autoimmune disease. Although they play a central role in maintaining self-tolerance, Tregs also
A powerful tool for the study of CD4 T cells in malaria
Although aimed at controlling invading pathogens, immune responses can sometimes be harmful to the host. Responses against the blood stage of malaria are an example of this: while B cells are activated and produce useful antibodies that
Curing glioblastoma with oncolytic virus and immune checkpoint blockade
Cancer immunotherapy utilizes the patient’s immune system to recognize and/or destroy tumors. The immune system has both positive activator/effector and negative inhibitory functions. Immune checkpoints are one such inhibitory function that can be overcome by immune checkpoint
Inner myeloid gene network as a nexus of hematopoiesis and infection
The immunological system is equipped with efficient and tunable mechanisms to remove immediately pathogens from our body. Invasion of microbes in the blood is an emergency state, because they can trigger inflammatory responses, leading to sepsis. Therefore,
The T cell IFT20 interactome: new insights into immune synapse assembly regulation by the IFT system
T lymphocytes are key cellular components of the immune system that are essential for the elimination of viral, bacterial and parasitic infections as well as of malignant cells. T cell activation is initiated following recognition of pathogen-
The role of monocytes in ANCA-associated vasculitides
The anti – neutrophil cytoplasm antibody (ANCA) – associated vasculitides (AAV) include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). These rare systemic autoimmune diseases affect small and medium – sized blood vessels, and are characterized by necrotizing vasculitis,
The gods of human T cell development
T cells are the component of the immune system required for recognizing and targeting pathogens and tumor cells. Because each T cell recognizes a different pathogen, the challenge of T cell development is to create a pool
Identification of a new T cell regulator
T-cell receptor (TCR) signaling is mediated by the activation of protein-tyrosine kinases such as p56lck and ZAP-70. In mature T-cells, CD4 and CD8 molecules bind to p56lck which then phosphorylates the intracellular immune-receptor tyrosine-based activation motifs (ITAM)
Oocyte activation and latent HIV-1 reactivation: AMPK links the creation of all human life and the potential eradication of HIV-1
In an active area of research known as HIV-1 cure research, the purposeful reactivation of latent/dormant HIV-1 in memory T cells, which induces death of the infected cell or alerts the immune system to the presence of
Hyper IgM syndrome in North America: a rare disease of a critical step in the immune response pathway
Hyper IgM (HIGM) syndromes are a group of rare genetic disorders leading to ineffective immune responses. People with this immune defect are usually diagnosed in early childhood due to frequent infections. Most of these are common but
BRAF inhibitor and interferon alpha combination for melanoma treatment
In recent years approval has been granted to many therapeutic agents for the treatment of patients with metastatic melanoma. They include small molecule inhibitors, such as the selective inhibitors of the mutant BRAF (BRAF-I) or of MEK (MEK-I), and
Image Cytometer – NucleoCounter® NC-3000™
The NucleoCounter® NC-3000™ is an advanced image cytometer utilizing fluorescence imaging to characterize cell properties. The NC-3000™ can perform high speed cell count and viability determination and includes plug-and-play analytical assays of mammalian, yeast and insect cells.
NucleoCounter® NC-200™ – Automated Cell Counter
The NucleoCounter® NC-200™ is a high precision automated cell counter utilizing state-of-the-art image cytometry. With user adaptable protocols and specialized assays for counting a wide range of mammalian cells, including adipose-derived stem cells, T cells, aggregated cells
How Vitamin C affects the immune system
DNA contains four bases, A, C, G and T (Fig.1). There are 3 billion of these bases in the human genome, and they code for about 22,000 genes. Because each cell carries the same genetic information –
Zinc – A beneficial player in autoimmune diseases
Essential trace elements, especially zinc, are indispensable for a proper immune function. Zinc deficiency or excess causes severe impairment of the immune response. So far, an increased susceptibility to infections, increased number of transplant rejections, development of
Aberrantly methylated DNA regions in IgA Nephropathy patients affect the disease
The genome can influence the onset and the development of the diseases in several manner, and in the last years several studies have revealed the new role of the DNA methylation in this framework. The DNA methylation
Special molecular mechanism makes CD147 an interesting drug target in cancer or autoimmune diseases
T cells are important players of the immune system, recognizing foreign or dangerous agents with their unique receptors. They defend the body from these agents either directly by killing or by recruiting or regulating other immune system
Vitamin D and T cells in multiple sclerosis: how to measure an effect?
Multiple sclerosis (MS) is an inflammatory disease of the brain, leading to disability in patients suffering from this disease. A type of white blood cells, T cells, are important pathogenic cells which drive this inflammation in early
The stromal vascular fraction: a regenerative reality?
In 2001, researchers discovered that fat tissue contains stem cells, which they termed adipose derived stem cells (ADSCs). To obtain these stem cells, fat tissue is taken from the abdomen of healthy adults undergoing liposuction and processed
B cells to the rescue: regulatory B cells are a promising therapeutic target for autoimmune disease
Immune cells are indispensable for protecting us from microbial infections. They recognize specific patterns on microbes to mount robust cellular and molecular immune responses for the clearance of pathogens. Intriguingly, development and function of these cells is
